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Gasteiz / Vitoria, Spain

Sanchez-Ilarduya M.B.,CIC Biomagune | Trouche E.,CIC Biomagune | Tejero R.,CIC Biomagune | Tejero R.,University of the Basque Country | And 7 more authors.
Journal of Biomedical Materials Research - Part A | Year: 2013

Plasma rich in growth factors (PRGFs) technology is an autologous platelet-rich plasma approach that provides a pool of growth factors and cytokines that have been shown to increase tissue regeneration and accelerate dental implant osseointegration. In this framework, the spatiotemporal release of growth factors and the establishment of a provisional fibrin matrix are likely to be key aspects governing the stimulation of the early phases of tissue regeneration around implants. We investigated the kinetics of growth factor release at implant surfaces functionalized either with PRGFs or platelet-poor plasma and correlated the results obtained with the morphology of the resulting interfaces. Our main finding is that activation and clot formation favors longer residence times of the growth factors at the interfaces studied, probably due to their retention in the adsorbed fibrin matrix. The concentration of the platelet-derived growth factors above the interfaces becomes negligible after 2-4 days and is significantly higher in the case of activated interfaces than in the case of nonactivated ones, whereas that of the plasmatic hepatocyte growth factor is independent of platelet concentration and activation, and remains significant for up to 9 days. Platelet-rich plasma preparations should be activated to permit growth factor release and thereby facilitate implant surface osseointegration. © 2013 Wiley Periodicals, Inc. Source


Tejero R.,University of the Basque Country | Anitua E.,BTI ID | Orive G.,BTI ID | Orive G.,University of the Basque Country | Orive G.,CIBER ISCIII
Progress in Polymer Science | Year: 2014

Replacing malfunctioning tissues with titanium-based implants has become a widespread practice spurred by population aging. Advances in biomaterials, technology and implantation protocols have led to increasing expectations on the applicability and durability of implants the field has recently moved from a bioinert to a bioactive paradigm due to surface modifications that trigger specific responses on the surrounding tissues. Biopolymeric surface coatings have taken up a central role in these developments the use of these and other biomimetic strategies on implants provides greater control over material-cell interactions and it is aimed at improving long-term clinical results by replicating some of the structures and mechanisms of living tissues. This review summarizes the state of the art of biomimetic implants and discusses the main directions and challenges of this field toward a more predictable and successful implant osseointegration. © 2014 Elsevier Ltd. Source

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