Daejeon, South Korea
Daejeon, South Korea

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Her Y.,BTGin Co. | Lee Y.-C.,KAIST | Oh J.-H.,BTGin Co. | Choi Y.-E.,Chonbuk National University | And 4 more authors.
Biotechnology and Bioprocess Engineering | Year: 2012

Over the past several decades, the pharmacological effects of ginsenosides in Panax ginseng roots have been extensively investigated. Here, we developed a method for producing specific ginsenosides (F1 and F2) with good yields (F1:162 mg/g, F2:305 mg/g) using β-glycosidase purified from Aspergillus niger. In addition, each ginsenoside (at least 25 species) was separated and purified by high performance liquid chromatography (HPLC) using five different types of solvents and different purification steps. In addition, the Rg3:Rh2 mixture (1:1, w/w) was shown to inhibit a specific lung cancer cell line (NCI-H232) in vivo, displaying an anticancer effect at a dose lower than achieved using treatments with single Rg3 or Rh2. This finding suggests that the combination of ginsenosides for targeting anticancer is more effective than the use of a single ginsenoside from ginseng or red ginseng. © 2012 The Korean Society for Biotechnology and Bioengineering and Springer.


Park J.-B.,Chungnam National University | Kwon S.K.,Chungnam National University | Nagar H.,Chungnam National University | Jung S.-B.,Chungnam National University | And 5 more authors.
Journal of Ginseng Research | Year: 2014

Background: Panax ginseng has distinct and impressive health benefits, such as improved blood pressure and immune system functioning. Rg3-enriched Korean Red Ginseng (REKRG) isolated from Korean Red Ginseng contains a high percentage of Rg3. Methods: In this study, we examined the effects of REKRG on endothelial cell nitric oxide synthase (eNOS) activation and adhesion molecules in endothelial cells and vascular function in rats. Results: REKRG dose-dependently increased eNOS phosphorylation and nitric oxide (NO) production in endothelial cells. In addition, REKRG markedly inhibited the tumor necrosis factor-α (TNF-α)-mediated induction of intercellular adhesion molecule (ICAM)-1 and cyclooxygenase (COX)-2 expressions in endothelial cells. REKRG improved endothelium-dependent vasorelaxation in the Wistar-Kyoto (WKY) rat and spontaneously hypertensive rats (SHRs) compared with controls. Furthermore, REKRG treatment for 6 weeks increased serum NO levels and reduced the mean aortic intima-media thickness compared with controls. Conclusion: Taken together, these results suggest that REKRG increased vascular function and improved immune system functioning. Therefore, REKRG is a very useful food for preventing or improving various cardiovascular diseases. © 2014, The Korean Society of Ginseng, Published by Elsevier. All rights reserved.


Park B.,Gachon University | Park B.,Korea University | Lee Y.-M.,Chungbuk National University | Kim J.-S.,University of Florida | And 4 more authors.
BMC Complementary and Alternative Medicine | Year: 2013

Background: Some of ginsenosides, root extracts from Panax ginseng, exert cytotoxicity against cancer cells through disruption of membrane subdomains called lipid rafts. Protopanaxadiol (PPD) exhibits the highest cytotoxic effect among 8 ginsenosides which we evaluated for anti-cancer activity. We investigated if PPD disrupts lipid rafts in its cytotoxic effects and also the possible mechanisms.Methods: Eight ginsenosides were evaluated using different cancer cells and cell viability assays. The potent ginsenoside, PPD was investigated for its roles in lipid raft disruption and downstream pathways to apoptosis of cancer cells. Anti-cancer effects of PPD was also investigated in vivo using mouse xenograft model.Results: PPD consistently exerts its potent cytotoxicity in 2 cell survival assays using 5 different cancer cell lines. PPD disrupts lipid rafts in different ways from methyl-β-cyclodextrin (MβCD) depleting cholesterol out of the subdomains, since lipid raft proteins were differentially modulated by the saponin. During disruption of lipid rafts, PPD activated neutral sphingomyelinase 2 (nSMase 2) hydrolyzing membrane sphingomyelins into pro-apoptotic intracellular ceramides. Furthermore, PPD demonstrated its anti-cancer activities against K562 tumor cells in mouse xenograft model, confirming its potential as an adjunct or chemotherapeutic agent by itself in vivo.Conclusions: This study demonstrates that neutral sphingomyelinase 2 is responsible for the cytotoxicity of PPD through production of apoptotic ceramides from membrane sphingomyelins. Thus neutral sphingomyelinase 2 and its relevant mechanisms may potentially be employed in cancer chemotherapies. © 2013 Park et al.; licensee BioMed Central Ltd.


Trademark
BTGin Co. | Date: 2011-11-10

Non-alcoholic rice nectar beverages; Guarana drinks; Fruit-flavored beverages; Fruit juices; Non-alcoholic beverages containing fruit juices; Mineral water; Preparations for making Mineral water; Honey-based beverages, non-alcoholic; Frozen fruit beverages; Peanut soft drink; Lager beers; Lemonades; Syrups for lemonade; Lemon squash; Lithia water; Malt beer; Malt wort; Beer; Beer wort; Extracts of Hops for making beer; Non-aerated water; Mandarin orange juices; Powders for effervescing beverages; Preparations for making effervescent beverages; Pastilles for effervescing beverages; Fruit nectars, non-alcoholic; non-alcoholic fruit extracts used in the preparation of fruit beverages; Fruit juice beverages, non-alcoholic; Cider, non-alcoholic; Aperitifs, nonalcoholic; Beverages, non-alcoholic; Cocktails, non-alcoholic; Apple juice beverages; Soda pop; Water beverages; Seltzer water; Soda water; Soft drinks, namely, sodas; Stout; Table waters; Orgeat; Milk of Almonds beverage; Isotonic beverages; Ale beer; Orange juice beverages; Imitation beer; Whey beverages; Powders used in the preparation of fruit based beverages; Fruit syrups for beverages; non-alcoholic fruit extracts used in the preparation of beverages; Sarsaparilla; Spring water beverages; Sherbets beverages; Syrups for beverages; Ginseng powders and extracts for making non-alcoholic beverages; Essences for making beverages; Ginseng juices; Ginger beer; Ginger ale; Vegetable or fruit processed beverages; Vegetable juices; Soft drinks; Cola syrup for making soft drinks; Kvass non-alcoholic beverages; Aerated water; Preparations for making aerated water; Tomato juice; Pineapple juice beverages; Grape must, unfermented; Grape juice beverages; Synthetic beer; Dark beer.


Trademark
BTGin Co. | Date: 2012-04-03

Non-alcoholic rice nectar beverages not being milk substitutes; Guarana drinks; Fruit-flavored beverages; Fruit juices; Non-alcoholic beverages containing fruit juices; Mineral water; Preparations for making Mineral water; Honey-based beverages, non-alcoholic; Frozen fruit beverages; Peanut soft drink; Lager beers; Lemonades; Syrups for lemonade; Lemon squash; Lithia water; Malt beer; Malt wort; Beer; Beer wort; Extracts of Hops for making beer; Non-aerated water; Mandarin orange juices; Powders for effervescing beverages; Preparations for making effervescent beverages; Pastilles for Effervescing beverages; Fruit nectars, non-alcoholic; non-alcoholic fruit extracts used in the preparation of fruit beverages; Fruit juice beverages, non-alcoholic; Cider, non-alcoholic; Aperitifs, non-alcoholic; Beverages, non-alcoholic, namely, fruit juice beverages, carbonated beverages; Cocktails, non-alcoholic; Apple juice beverages; Soda pop; Seltzer water; Soda water; Stout; Table waters; Orgeat, namely, orgeat syrups for use as a flavoring in non-alcoholic beverages, non-alcoholic fruit beverages; Milk of Almonds beverage; Isotonic beverages; Ale beer; Orange juice beverages; Imitation beer; Whey beverages; non-alcoholic fruit extracts used in the preparation of beverages; Fruit syrups for beverages; Fruit extracts for beverages; Syrups for making non-alcoholic beverages; Ginseng powders and extracts for making non-alcoholic beverages; Essences for making non-alcoholic beverages; Ginseng juices; Ginger beer; Ginger ale; Vegetable or fruit processed beverages; Vegetable juices; Soft drinks; Cola syrup for making soft drinks; Aerated water; Preparations for making Aerated water; Tomato juice; Pineapple juice beverages; Grape must, unfermented; Grape juice beverages; Synthetic beer; Dark beer.


Trademark
BTGIN Co. | Date: 2015-01-30

Guarana drinks; non-alcoholic beverages containing fruit juices; non-alcoholic honey-based beverages; non-alcoholic cider; non-alcoholic aperitifs; non-alcoholic carbonated beverages; non-alcoholic cocktails; ginseng powder for making energy drinks; ginseng juice; soft drinks; energy drinks containing guarana extracts; energy drinks containing ginseng extracts; ginseng extracts for use in the preparation of energy drinks; fruit extracts for use in the preparation of energy drinks; fruit drinks and fruit juices.


PubMed | BTGin Company Ltd, Hanbat National University and Chungnam National University
Type: Journal Article | Journal: Journal of ginseng research | Year: 2014

Panax ginseng has distinct and impressive health benefits, such as improved blood pressure and immune system functioning. Rg3-enriched Korean Red Ginseng (REKRG) isolated from Korean Red Ginseng contains a high percentage of Rg3.In this study, we examined the effects of REKRG on endothelial cell nitric oxide synthase (eNOS) activation and adhesion molecules in endothelial cells and vascular function in rats.REKRG dose-dependently increased eNOS phosphorylation and nitric oxide (NO) production in endothelial cells. In addition, REKRG markedly inhibited the tumor necrosis factor- (TNF-)-mediated induction of intercellular adhesion molecule (ICAM)-1 and cyclooxygenase (COX)-2 expressions in endothelial cells. REKRG improved endothelium-dependent vasorelaxation in the Wistar-Kyoto (WKY) rat and spontaneously hypertensive rats (SHRs) compared with controls. Furthermore, REKRG treatment for 6 weeks increased serum NO levels and reduced the mean aortic intima-media thickness compared with controls.Taken together, these results suggest that REKRG increased vascular function and improved immune system functioning. Therefore, REKRG is a very useful food for preventing or improving various cardiovascular diseases.

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