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London, United Kingdom

BTG plc, a public limited company is an international specialty pharmaceuticals company that is developing and commercialising products targeting critical care, cancer, neurological and other disorders. The company is also seeking to acquire new products to develop and market to hospital specialists, and is building a sustainable business financed by revenues from sales of its critical care products and from royalties and milestone payments on partnered products. Wikipedia.

Btg | Date: 2015-01-26

A method is described for providing acute symptomatic relief to a subject with Parkinsons Disease (PD) or other CNS disorders resulting from dopamine deficiency in the brain comprising administering to said subject an amount of a ketogenic material sufficient to produce a ketosis in the subject sufficient to provide therapeutic benefit in such neurological disorders. Preferred materials produce a ketosis is such that the total concentration of acetoacetate and (R)-3-hydroxybutyrate in the blood of the subject is raised to between 0.1 and 30 mM.

A salt of a compound of formula (I) may be made with methanesulfonic acid. The salt and salts with other acids may be prepared by recovering from methyl tert-butyl ether (MTBE).

A method is provided for treating a patient suffering from apoptosis of tissue comprising administering to that subject a therapeutically effective amount of one or more ketogenic compounds such that a physiological ketosis is produced sufficient to arrest said apoptosis. Preferably the apoptosis is of cerebral tissue such as that associated with acute intractible seizures, particularly with status epilepticus. The method is also applicable to apoptosis associated with administration of toxic stuimuli for treatment of cancer, that produced by viral infections, autoimmune diseases or Aquired Immuno Difficiency Syndrome. The ketosis produced is a state in which levels of one or both of acetoacetate and (R)-3-hydroxybutyrate concentrations in the blood of the subject such that their total concentration in the blood is elevated above the normal fed levels to between 0.1 and 30 mM. Also provided is the use of ketogeic material to in the manufacture of a medicament for the treatment of apoptosis and pharmaceutical compositions for such treatment.

A device for sampling, preparing and analysing a sample, for example a suspension, comprises: a sampling device adapted to sampling a fluid sample, at least one sample preparation unit adapted to prepare the sample, and at least one analysing unit. By adapting the device for sampling and analysing a sample for placement in direct vicinity to a process pipe and adapting the sampling device to sample a fluid sample directly from a gate, a compact and cost-efficient device is provides, which also provides fast feedback to a process to be controlled.

A method of determining a property of a heterogeneous medium in motion comprising at least two phases is provided. A light beam is made small in relation to a part of the medium for which a property is to be determined and the bandwidth of the measurement signal is sufficiently high for distinguishing time periods for the measurement signal which are related to the part of the medium for which a property is to be determined. By using the measurement signal for determining the property of the part of the medium for which a property is to be determined for time periods for the measurement signal which are related to that part of the medium, and determining the property by a mathematical calculation using the measurement signal corresponding to that part of the medium, the properties of individual parts of the medium can be determined.

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