Pandya V.M.,Bs Patel Pharmacy College |
Patel J.K.,Nootan Pharmacy College |
Patel D.J.,Shree Krishna Institute of Pharmacy
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010
Low oral bioavailability of poorly water-soluble drugs poses a great challenge during drug development. Poor water solubility and slow dissolution rate are issues for the majority of upcoming and existing biologically active compounds. Simvastatin is BCS class-II drugs having low solubility and high permeability. The aim of the present investigation was to find out the effect of different stabilizer on the formulation of simvastatin nanosuspension. Prepared nanosuspensions was evaluated for its particle size study, invitro dissolution study and characterized by Screening Electron microscopy (SEM). The obtained results showed that nanosuspension prepared with the PVPK-30 has improved dissolution rate as compare to all other stabilizer because of decreases in particle size (417nm) as compared to micro suspension of simvastatin. These results indicate the suitability of PVPK-30 as a stabilizer in the formulation of nanosuspension.
Gunjan J.P.,Bs Patel Pharmacy College |
Darshan A.M.,Bs Patel Pharmacy College
Journal of Pharmacy and Bioallied Sciences | Year: 2012
The aim of present research was to develop a fast releasing oral polymeric film, with good mechanical properties, instant disintegration and dissolution, producing an acceptable taste when placed on tongue. Solvent casting method was used to prepare oral films. Levocetirizine dihydrochloride, an antihistaminic was incorporated to relieve the symptoms of allergic rhinitis. The polymers selected were HPMC E 15 and PVA. Propylene glycol was the plasticizers used. Nine batches of films with drug were prepared using different combinations of polymers and plasticizer concentration. The resultant films were evaluated for weight variation, content uniformity, folding endurance, thickness, surface pH, in vitro disintegration and in vitro dissolution. The optimized films which disintegrated in less than 30 sec, releasing 85-98% of drug within 2 minutes. The percentage release was varying with concentration of plasticizer and polymer. The films made with HPMC: PVA (1:2) released 96% of drug in 1 min, which was the best release amongst all.
Patel N.G.,Bs Patel Pharmacy College |
Patel N.J.,Ganpat University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2010
Skin diseases accounts for 10-20% of all consultations in general practice. Most common skin complaints are Dermatitis, Eczema, Acne, Urticaria, Psoriasis, skin allergy etc.They do not cured completely. We have carried out epidemiological study among skin diseases patients in the region of North Gujarat State with the objectives to check the skin problems, to identify if any common patients life style factors is responsible for skin problems, to study the symptoms of skin complications, to study the drug prescription and drug utilization in skin problems and to study the pharmacoeconomics of the skin problems. Randomly 521 patients were approached with pre-prepared questionnaires directly at clinics and hospitals of general physician and skin specialist. Acne or pimples (14%), Eczema (8%), Non-specific infections (11%), Hyper pigmentation (7%) and Alopecia (9%) were the most prevalent skin related complications among these patients. Itching (80%) was the common symptoms with redness (18%), swelling and inflammation (17%). Awareness of people among food and food habit observed quite less which might be responsible for development of skin diseases. The prescriptions of anti-histaminic drug were found higher and are rational because about 80% patients were itching problem with skin diseases. Similarly use of analgesics and anti-inflammatory drug is also rational with the swelling and inflammatory symptoms in patients. The treatment of skin complications was found more or less rational, however few irrational prescription were also found. Cost of the treatment for skin diseases was comparatively higher which increase economic burden to the patients which can be minimize by patient awareness.
Patel D.A.,Bs Patel Pharmacy College |
Patel A.R.,Bs Patel Pharmacy College |
Pandya V.,Bs Patel Pharmacy College |
Modi D.,Bs Patel Pharmacy College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011
Drug targeting implied the method for localizing a therapeutic agent on the minority of cells that are actually in need of treatment. This system allows the administration of a drug to a selected target area at the proper therapeutic dosage by the use of colloidal drug carriers which includes liposome, Niosome, Microspheres, Released erythrocytes, Immunoglobulin, Serum-proteins, and Synthetic polymers. Enhancement of activity duration for short half-life drug; Elimination of side effects, Maintenance of optimum therapeutic drug concentration in the blood with minimum fluctuation can be achieved by this techniques. © 2010 RJPBCS.