Billerica, MA, United States
Billerica, MA, United States

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Patent
Bruker Daltonics Inc. | Date: 2016-01-27

The invention provides a cathode system for an Electron Ionization (EI) source comprising a filament and current supply posts, the current supply posts dividing the filament into segments and each current supply post supplying or returning the current for at least two segments of the filament. Each filament segment is connected, for instance by spot welding, to the supply posts delivering the heating current. The filament segments may be arranged in a row, or substantially parallel to each other. Filament segments arranged in a row may form a closed loop, for instance, a ring. Other embodiments encompass the filament shape of a helical coil.


Patent
Bruker Daltonics Inc. | Date: 2015-01-07

The invention generally relates to an assembly of a first RF component and a second RF component in a mass spectrometer, the first RF component comprising a first set of electrodes and the second RF component comprising a second set of electrodes, wherein the RF components are located and aligned end-to-end to one another, and wherein a transverse dimension of the electrodes of the first set is smaller than that of the electrodes of the second set. The assembly further comprises a conductive electric field screen located at an outer periphery of the first set of electrodes and facing the electrodes of the second set as to reduce RF electric field cross-talk between the electrodes of the first set and those of the second set. The invention affords for technically simple and economic means to reduce cross-talk or capacitive coupling between adjacent RF components in a mass spectrometer.


The present invention relates to electrospray ionization (ESI) at atmospheric pressure coupled with a mass spectrometer, in particular to a special kind of micro-electrospray with liquid flows in the range of 0.1 to 100 microliters per minute. The invention describes the use of an off-axis pre-entrance channel in an ESI ion source to prevent particulate matter with higher inertia than the (charged) gas molecules, such as droplets, from entering the mass spectrometer. The elimination of the particulate matter improves the quantitative precision of an LC/MS bioassay, minimizes the contamination of the mass spectrometer and improves the robustness for high throughput assays.


Patent
Bruker Daltonics Inc. | Date: 2016-06-15

The invention relates to a radio frequency ion guide construction for use in mass spectrometry that minimizes contamination by allowing ions rejected by the RF confinement field to fly through and away from the ion guide electrodes and preventing them from hitting the sensitive electric potential defining surfaces of the ion guide electrodes. At the entrance end of the ion guide, each electrode of the plurality of electrodes has a front end that is forked or that contains a recessed feature facing an interior of the ion guide. For an electrode that is forked, the teeth of the forked end may have different shapes or tapers, and a conductive mesh may be used to cover a gap between the teeth. Similarly, for an electrode that has a recessed feature, a conductive mesh may cover the recessed feature.


An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. Additional embodiments can act as linear ion traps or Paul ion traps.


Patent
Bruker Daltonics Inc. | Date: 2015-03-02

An improved trap-TOF mass spectrometer has a set of electrodes arranged to produce both a quadrupolar RF confining field and a substantially homogeneous dipole field. In operation, ions are first confined by the RF field and then, at a selected time, the RF confining field is discontinued and the dipole field is used to accelerate the ions so as to initiate a TOF MS analysis. The apparatus of the present invention may be used alone or in conjunction with other analyzers to produce mass spectra from analyte ions.


Patent
Bruker Daltonics Inc. | Date: 2015-12-23

The invention provides methods and devices to pulse ions from an RF ion storage into the flight tube of a time-of-flight mass spectrometer. The pusher cell comprises essentially two parallel plates, both plates completely slotted into two electrically insulated halves. The four half plates can be supplied with RF voltages to form a two-dimensional quadrupole field in the center between the slits, or with DC voltages to form a homogeneous acceleration field to eject ions. The RF quadrupole field is not ideal, but sufficiently good to store ions, to damp the ions by an additional collision gas, and to form a fine thread of ions in the axis of the quadrupole field. The DC acceleration field is extremely homogeneous; slight distortions near the slits can be corrected by external electrodes. The ideal acceleration field results in a high mass resolution and the device does not show any mass discrimination.


Patent
Bruker Daltonics Inc. | Date: 2016-06-08

The invention relates to a mass spectrometer having an ion source region at substantially atmospheric pressure in which ions are formed from a liquid sample. The mass spectrometer further has an interface for transmitting the formed ions from the ion source region into a vacuum region which is held at a pressure level substantially below the atmospheric pressure and where the formed ions are further processed. The interface comprises a wall dividing the ion source region and the vacuum region and has a central orifice formed therein for letting pass gaseous and particulate matter from the ion source region into the vacuum region following the pressure gradient, wherein the central orifice is surrounded at least section-wise by a plurality of lateral orifices.


The present invention relates to electrospray ionization (ESI) at atmospheric pressure coupled with a mass spectrometer, in particular to a special kind of micro-electrospray with liquid flows in the range of 0.1 to 100 microliters per minute. The invention describes the use of an off-axis pre-entrance channel in an ESI ion source to prevent particulate matter with higher inertia than the (charged) gas molecules, such as droplets, from entering the mass spectrometer. The elimination of the particulate matter improves the quantitative precision of an LC/MS bioassay, minimizes the contamination of the mass spectrometer and improves the robustness for high throughput assays.


Patent
Bruker Daltonics Inc. | Date: 2014-03-05

An atmospheric pressure ion source, employing the principle of electrospray ionization, chemical ionization, or photo-ionization, comprises a spray probe for spraying a liquid into an ionization chamber and has an exhaust port through which residual spray mist and waste gas, such as evaporated solvent, are extracted. The ion source further comprises an exhaust system comprising a conduit which is connected to the exhaust port. The conduit has a transition from a first cross-section to a second cross section at a point downstream of the exhaust port wherein the second cross section is reduced in relation to the first cross section. Gas is injected via a gas injector into the conduit in a region of the transition to create a low pressure region that removes unwanted material from the chamber.

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