Brown University is a private Ivy League research university in Providence, Rhode Island.Founded in 1764 as "The College in the English Colony of Rhode Island and Providence Plantations," Brown is the seventh-oldest institution of higher education in the United States and one of the nine Colonial Colleges established before the American Revolution. At its foundation, Brown was the first college in the United States to accept students regardless of their religious affiliation. Its engineering program, established in 1847, was the first in what is now known as the Ivy League. Brown's New Curriculum—sometimes referred to in education theory as the Brown Curriculum—was adopted by faculty vote in 1969 after a period of student lobbying; the New Curriculum eliminated mandatory "general education" distribution requirements, made students "the architects of their own syllabus," and allowed them to take any course for a grade of satisfactory or unrecorded no-credit. In 1971, Brown's coordinate women's institution, Pembroke College was fully merged into the university.The undergraduate acceptance rate is among the country's most selective with an acceptance rate of 8.6% for the class of 2018. The University comprises The College, the Graduate School, Alpert Medical School, the School of Engineering, the School of Public Health, and the School of Professional Studies . Brown's international programs are organized through the Watson Institute for International Studies. The Brown/RISD Dual Degree Program, offered in conjunction with the Rhode Island School of Design, is a five-year course that awards degrees from both institutions.Brown's main campus is located in the College Hill Historic District in the city of Providence, the second largest city in New England. The University's neighborhood is a federally listed architectural district with a dense concentration of ancient buildings. On the western edge of the campus, Benefit Street contains "one of the finest cohesive collections of restored seventeenth- and eighteenth-century architecture in the United States".Brown University is home to many prominent alumni, known as Brunonians, including current president of the World Bank Jim Yong Kim and Chair of the Federal Reserve Janet Yellen. While considered a small research university, Brown has been affiliated with 7 Nobel laureates as students, faculty, or staff. It has been associated with 54 Rhodes Scholars, 5 National Humanities Medalists, 10 National Medal of Science laureates, and is a leading producer of Fulbright Scholars. Wikipedia.
Powers T.R.,Brown University
Reviews of Modern Physics | Year: 2010
Motivated by the motion of biopolymers and membranes in solution, this article presents a formulation of the equations of motion for curves and surfaces in a viscous fluid. The focus is on geometrical aspects and simple variational methods for calculating internal stresses and forces, and the full nonlinear equations of motion are derived. In the case of membranes, particular attention is paid to the formulation of the equations of hydrodynamics on a curved, deforming surface. The formalism is illustrated by two simple case studies: (1) the twirling instability of straight elastic rod rotating in a viscous fluid and (2) the pearling and buckling instabilities of a tubular liposome or polymersome. © 2010 The American Physical Society. Source
Brown University | Date: 2015-01-20
A method and nanoparticle construct provides shielded delivery of a drug or agent to a tissue or treatment site, and release of the agent may be triggered externally. Carbon nanotubes (CNTs) are filled with the therapeutic agent in a temperature sensitive gel, and release of the agent is effected by inductive heating, e.g. applying an alternating or pulsed magnetic field, or electrical field. The CNTs may be functionalized for solubility, drug absorption, responsivity to pH, enzyme catalysis, and/or ambient biological environment. Encapsulation within the nanostructure protects the intracorporal or surrounding cellular environment from the potentially toxic cargo and prevents the degradation of the cargo during delivery. By releasing at or in the target tissue extremely small amounts of the agent may achieve an effective level of treatment, as measured by cell apoptosis, tumor shrinkage or other treatment effect while safely avoiding systemic damage.
Brown University | Date: 2015-08-06
Therapeutic compositions for treatment of protein serine/threonine phosphatase-related diseases are obtained by engineering amino acid sequences that disrupt interaction between the protein serine/threonine phosphatase and a protein inhibitor and are provided herein. Calcineurin and PPI are examples of protein serine/threonine phosphatases. RCAN1 is an inhibitor of calcineurin and is overexpressed in patients with serious diseases, such as Down syndrome and Alzheimers disease. Molecules that bind RCAN1 at regions that interact with calcineurin selectively modulate functions of calcineurin to treat these diseases. Methods of treating a subject for a protein serine/threonine phosphatase-related disease by administering a molecule having an amino acid sequence selected from the group of SEQ ID NOs: 1-19 are further provided.
Brown University | Date: 2015-09-25
A method obtains the shape of a target by projecting and recording images of dual frequency fringe patterns. Locations in each projector image plane are encoded into the patterns and projected onto die target while images are recorded. The resulting images show the patterns superimposed onto the target. The images are decoded to recover relative phase values for the patterns primary and dual frequencies. The relative phases are unwrapped into absolute phases and converted back to projector image plane locations. The relation between camera pixels and decoded projector locations is saved as a correspondence image representing the measured shape of the target. Correspondence images with a geometric triangulation method create a 3D model of the target. Dual frequency hinge patterns have a low frequency embedded into a high frequency sinusoidal, both frequencies are recovered in closed form by the decoding method, thus, enabling direct phase unwrapping.
Brown University and Rhode Island Hospital | Date: 2015-02-19
An MRI contrast material includes tumor-targeting metal-loaded ferritin nanoparticles constructed with genetically modified ferritin coupled to a target-specific agent. Ferritin derived from