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Brooklyn, NY, United States

Brooklyn College is a senior college of the City University of New York, located in Brooklyn, New York, United States.Established in 1930 by the New York City Board of Higher Education, the College had its beginnings as the Downtown Brooklyn branches of Hunter College and the City College of New York . With the merger of these branches, Brooklyn College became the first public coeducational liberal arts college in New York City. The 26-acre campus is known for its great beauty, and is often regarded as "the poor man's Harvard" because of its low tuition and reputation for academic excellence .The school was ranked as the most beautiful campus and in the top ten for value, diversity, and location by The Princeton Review in 2003 and in the top fifty for value in 2009. Wikipedia.

Zhou N.-F.,Brooklyn College
Theory and Practice of Logic Programming | Year: 2012

B-Prolog is a high-performance implementation of the standard Prolog language with several extensions including matching clauses, action rules for event handling, finite-domain constraint solving, arrays and hash tables, declarative loop constructs, and tabling. The B-Prolog system is based on the Tree-Oriented Abstract Machine (TOAM) architecture which differs from the Warren Abstract Machine (WAM) mainly in that (1) arguments are passed old fashionedly through the stack, (2) only one frame is used for each predicate call, and (3) instructions are provided for encoding matching trees. The most recent architecture, called TOAM Jr., departs further from the WAM in that it employs no registers for arguments or temporary variables, and provides variable-size instructions for encoding predicate calls. This paper gives an overview of the language features and a detailed description of the TOAM Jr. architecture, including architectural support for action rules and tabling. © Copyright Cambridge University Press 2011. Source

Sclafani A.,Brooklyn College
Appetite | Year: 2013

Multiple hormonal and neural signals are generated by ingested nutrients that limit meal size and suppress postmeal eating. However, the availability of sugar-rich and fat-rich foods can override these satiation/satiety signals and lead to overeating and obesity. The palatable flavor of these foods is one factor that promotes overeating, but sugar and fat also have postoral actions that can stimulate eating and increase food preferences. This is revealed in conditioning studies in which rodents consume flavored solutions paired with intragastric sugar or fat infusions. The significant flavor preferences and increased intake produced by the nutrient infusions appear to involve stimulatory gut-brain signals, referred to here as appetition signals, that are distinct from the satiation signals that suppress feeding. Newly developed rapid conditioning protocols may facilitate the study of postoral appetition processes. © 2012 Elsevier Ltd. Source

Giovambattista N.,Brooklyn College | Rossky P.J.,University of Texas at Austin | Debenedetti P.G.,Princeton University
Annual Review of Physical Chemistry | Year: 2012

The behavior of water confined on nanometer length scales is important in a diverse set of technical and scientific contexts, ranging from the performance of fuel cells and biological molecular machines to the design of self-assembling nanoscale materials. Here, we review recent insights into the structure and thermodynamics of confined water that have been elucidated primarily by computer simulation studies. We emphasize investigations in which interfacial chemistry and molecular topography are varied systematically and in which a wide range of thermodynamic conditions of temperature and pressure are explored. We consider homogeneous interfaces ranging from the simplest hard wall to chemically realistic, but structurally ideal, hydrophobic and hydrophilic surfaces, and the continuous scale of surface polarity is investigated. Features associated with interface heterogeneities arising from chemical patterning or from the natural characteristics of protein surfaces are discussed. Finally, we provide our thoughts on important directions for further studies. © Copyright ©2012 by Annual Reviews. All rights reserved. Source

Sclafani A.,Brooklyn College
Cell Metabolism | Year: 2016

Intestinal sugar sensing has an appetite-stimulating action that enhances preferences for sweets. Han et al. (2016) report that duodenal-jejunal bypass surgery reduces sweet appetite by reducing sugar-induced dopamine release in the dorsal striatum. © 2016 Elsevier Inc. Source

Quadri L.E.N.,Brooklyn College
Critical Reviews in Biochemistry and Molecular Biology | Year: 2014

Over a decade ago, the analysis of the complete sequence of the genome of the human pathogen Mycobacterium tuberculosis revealed an unexpectedly high number of open reading frames encoding proteins with homology to polyketide synthases (PKSs). PKSs form a large family of fascinating multifunctional enzymes best known for their involvement in the biosynthesis of hundreds of polyketide natural products with diverse biological activities. The surprising polyketide biosynthesis capacity of M. tuberculosis has been investigated since its initial inference from genome analysis. This investigation has been based on the genes found in M. tuberculosis or their orthologs found in other Mycobacterium species. Today, the majority of the PKS-encoding genes of M. tuberculosis have been linked to specific biosynthetic pathways required for the production of unique lipids or glycolipid conjugates that are critical for virulence and/or components of the extraordinarily complex mycobacterial cell envelope. This review provides a synopsis of the most relevant studies in the field and an overview of our current understanding of the involvement of PKSs and several other polyketide production pathway-associated proteins in critical biosynthetic pathways of M. tuberculosis and other mycobacteria. In addition, the most relevant studies on PKS-containing biosynthetic pathways leading to production of metabolites from mycobacteria other than M. tuberculosis are reviewed. © 2014 Informa Healthcare USA, Inc. Source

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