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St. Catharines, Canada

Brock University is a public research university located in St. Catharines, Ontario, Canada. It is the only university in Canada that is located in a UNESCO Biosphere Reserve, located at the centre of Canada's Niagara Peninsula on the Niagara Escarpment. The university bears the name of Maj.-General Sir Isaac Brock, who was responsible for defending Upper Canada against the United States during the War of 1812.Brock offers a wide range of programs at the undergraduate and graduate levels, including professional degrees. Brock was ranked 3rd among Canadian universities in the "undergraduate" category for research publication output and impact indicators in 2008. Brock University is the only school in Canada and internationally to offer the MICA program. Brock University's Department of Health science offers the only undergraduate degree in Public Health in Canada. At the graduate level, Brock offers 37 programs, including 6 PhD programs.Brock's Co-op program is Canada’s fifth-largest, and the third largest in Ontario as of 2011. Graduates enjoy one of the highest employment rates of all Ontario universities at 97.2 percent.Brock has 12 Canada Research Chairs and 9 faculty members which have received the 3MTeaching Fellowship Award, the only national award that recognizes teaching excellence and educational leadership. Wikipedia.


A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone.


The present application is directed to an efficient conversion of C-14 hydroxylated morphine alkaloids to various morphine analogs, such as naltrexone, naloxone and nalbuphone. One feature of this process is an intramolecular functional group transfer from the C-14 hydroxyl to the N-17 nitrogen atom following a palladium-catalyzed N-demethylation.


Patent
Brock University | Date: 2014-05-05

The present disclosure relates to methods for the chromatographic separation of two or more sample components using a column while applying a time-pulsed pressure differential to the column and to apparatus for use in the same.


The present application is directed to an efficient conversion of C-14 hydroxylated morphine alkaloids to various morphine analogs, such as naltrexone, naloxone and nalbuphone. One feature of this process is an intramolecular functional group transfer from the C-14 hydroxyl to the N-17 nitrogen atom following a palladium-catalyzed N-demethylation.


A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone.

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