News Article | February 15, 2017
A national breast cancer research project has chosen Sanford Health to be the repository for the specimens collected as part of the 100,000 woman study. The five-year study is called Women Informed to Screen Depending on Measures of risk, or WISDOM, and is being conducted by the Athena Breast Health Network, a collaboration among five University of California medical centers and Sanford Health’s Edith Sanford Breast Center. Investigators are studying routine annual screenings and personalized screenings based on genetic information to determine which method is more effective in reducing false positives and misdiagnoses of breast cancer. Sanford’s genomic lab will house the specimens collected from consenting women as part of this research. The study will enroll 100,000 women across the United States. Researchers from across the globe will have access to the data collected to use in other breast cancer studies. “Sanford Health has been an outstanding partner in our breast health research and clinical care initiatives here at the University of California,” said Sandy Borowsky, the principal investigator at the University of California, Davis site of Athena. “Sanford demonstrated a commitment to improving care for women through innovative thinking and the hard work of collecting data across multiple sites. Their professionalism and institutional support for a first class biospecimen lab made the choice clear. It’s a true win-win opportunity.” The Athena Breast Health Network in 2015 received a $14.1 million grant from the Patient-Centered Outcomes Research Institute, or PCORI, to fund WISDOM. Edith Sanford Breast Center has been a member of Athena since 2013. Other partners include the University of California campuses in San Francisco, San Diego, Davis, Los Angeles and Irvine. “Sanford Health enjoys beneficial integration of its clinical and research operations, which has provided us the infrastructure to support the WISDOM repository,” said David Pearce, Ph.D., executive vice president for Sanford Research. “The data gathered and stored here have the potential to improve breast cancer screenings for women everywhere.” Women age 40-74 years old who have not had a prior breast cancer diagnosis and receive care at an Athena site are eligible to enroll. Edith Sanford Breast Center in Sioux Falls expects to open enrollment in early 2017. About Sanford Health Sanford Health is an integrated health system headquartered in the Dakotas. It is one of the largest health systems in the nation with 45 hospitals and nearly 300 clinics in nine states and four countries. Sanford Health’s 28,000 employees, including more than 1,300 physicians, make it the largest employer in the Dakotas. Nearly $1 billion in gifts from philanthropist Denny Sanford have allowed for several initiatives, including global children's clinics, genomic medicine and specialized centers researching cures for type 1 diabetes, breast cancer and other diseases. For more information, visit sanfordhealth.org.
News Article | February 28, 2017
Cancer Breakthroughs 2020, the world’s most comprehensive cancer collaborative initiative focusing on combination immunotherapy, has selected Sanford Health as one of three sites nationwide to launch the program’s first clinical trial. The study will explore an immunotherapy vaccine for patients with certain types of advanced breast cancer. Cancer Breakthroughs 2020 was created in early 2016 by Dr. Patrick Soon-Shiong, to facilitate collaboration among multinational pharmaceutical, biotechnology companies, academic centers and community oncologists in an effort to test novel immunotherapy protocols in combination with other treatment methods. “Our mission at Cancer Breakthroughs 2020 is to turn cancer into a chronic disease, not a life-threatening disease,” said Soon-Shiong. “Sanford Health is a key partner in helping us achieve that goal. Their drive to bring advanced cancer treatment options to even the most rural areas shows their commitment to fighting cancer.” Amy Sanford, M.D., an oncologist at Edith Sanford Breast Center in Sioux Falls, is the trial’s principal investigator. Her team will study if an immunotherapy vaccine designed to strengthen the body’s immune system can help patients fight breast cancer that cannot be treated with surgery or that has metastasized and is characterized by the HER2 gene. “After years of offering clinical trials and ranking the potential of immunotherapy high on Sanford’s list of priorities, the power of our comprehensive clinical research program is evident by Cancer Breakthroughs 2020’s selection of Sanford to help start the inaugural study of the project,” said David Pearce, Ph.D., executive vice president for Sanford Research. “The next generation standard of care will be the result of teamwork among organizations like Cancer Breakthroughs 2020 and Sanford Health.” Sanford Health has been involved in Cancer Breakthroughs 2020 since its inception early last year. In February, Sanford was announced as a founding member of the Cancer Breakthroughs 2020 Pediatrics Consortium. Sam Milanovich, M.D., is among the national experts using comprehensive cancer molecular diagnostic testing to study pediatric forms of cancer. This summer, Patrick Soon-Shiong, M.D., the founder of Cancer Breakthroughs 2020, finalized a relationship with Sanford Health to work clinical trials for human papillomavirus-, or HPV-, related cancers like head and neck cancer, cervical cancer and anal cancer. The study is open at Edith Sanford Breast Center in Sioux Falls. For information or to enroll, call 1-87-SURVIVAL. About Cancer Breakthroughs 2020 The Cancer Breakthroughs 2020 program is one of the most comprehensive cancer collaborative initiative launched to date, seeking to accelerate the potential of combination immunotherapy as the next generation standard of care in cancer patients. This initiative aims to explore a new paradigm in cancer care by initiating randomized Phase II trials in patients at all stages of disease in 20 tumor types in 20,000 patients within the next 36 months. These findings will inform Phase III trials and the aspirational breakthroughs to develop an effective vaccine-based immunotherapy to combat cancer by 2020. For more information, please visit http://www.cancerbreakthroughs2020.org and follow @Cancer2020 on Twitter. About Sanford Health Sanford Health is an integrated health system headquartered in the Dakotas. It is one of the largest health systems in the nation with 45 hospitals and nearly 300 clinics in nine states and four countries. Sanford Health’s 28,000 employees, including more than 1,300 physicians, make it the largest employer in the Dakotas. Nearly $1 billion in gifts from philanthropist Denny Sanford have allowed for several initiatives, including global children's clinics, genomic medicine and specialized centers researching cures for type 1 diabetes, breast cancer and other diseases. For more information, visit sanfordhealth.org.
News Article | November 29, 2016
This October, the Premier Group, a leading owner and operator of funeral home businesses in the US, sponsored a unique corporate-wide initiative to support Breast Cancer Awareness Month. Employees at Premier’s funeral homes wore pink ties and scarves to show their support for the cause. Also, the businesses developed special initiatives to back local organizations that support breast cancer treatment, awareness and research. Local initiatives included donations, fundraisers, volunteering, and other efforts. The Premier Group provided financial support and assistance to develop and sponsor these locally focused initiatives. “Many - if not most - people have been affected by breast cancer in some way,” said Premier CEO, Barry Bedford. “Our staff wanted to not only show their support by wearing pink, but also give back to our local communities, to people who are actually living with the disease.” “We couldn’t be more pleased to support Breast Cancer Awareness Month as a company,” said Troy Centazzo, Premier’s President. “But what’s really special about this initiative is that all of our local teams developed support programs that are focused on the specific needs of their communities. It’s been a bottom up, not top-down approach.” Premier Group’s funeral homes are invested in their local communities and each made donations to organizations that offer educational resources, provide support for survivors, and fund breast cancer research. Recipients included local branches of the Susan G. Komen Foundation, which provides services on the state and city level. Other donations were made directly to local medical clinics such as the Leah M. Fitch Cancer Center in Lawton, OK, and the Elizabeth Reilly Breast Center in Hendersonville, NC. Some funeral homes chose to sponsor community-specific fundraisers that each benefited breast cancer research, including a local softball tournament and even a “Tractor Pull” put on by a local high school. With locations throughout the country, Premier wanted its funeral homes to come together to show support for this important cause. These businesses serve families that are directly impacted by breast cancer, and many staff members have even battled cancer themselves. “One in eight women in the United States will develop breast cancer and even men can be affected,” said Bedford. “If anything, our team hopes that our initiatives motivated people to take action with their health since early detection is key.” A critical aspect of Premier’s approach to providing funeral home services in smaller communities is its extensive support of causes and charities that are important to the staffs and the areas they serve. In recent years, Premier Group funeral homes have leveraged their community influence to successfully raise much-needed awareness and funds for important local causes. Cancer-related organizations that Premier funeral homes have supported include Relay for Life, the Danny Bell Cancer Center in Poplar Bluff, MO, and the United Cancer Assistance Network. In June, Premier Sharp Funeral Home in Tennessee hosted a silent auction fundraiser benefiting the Oliver Springs Historical Society that raised over $4,000. In January of last year, Missouri’s Cotrell Funeral Service raised $6,000 for the United Cancer Assistance Network during their 135th anniversary celebration. Founded in 2011, the Premier Group is a privately-held owner and operator of funeral homes in smaller, or “secondary,” markets in the United States. The company is led by industry veterans and focuses on partnering with the leading funeral home businesses in their market areas. Premier provides its local funeral homes professional services, like back-office support, technical assistance, and funeral home marketing so the local staffs can focus on supporting their client families and communities. For more information on Premier Group or selling a funeral home, visit http://www.premierfuneral.net, call (317) 566-2072, or email info(at)premierfuneral.net. Connect with Premier Group on social media by following us on Twitter: @premierfuneral or on LinkedIn: https://www.linkedin.com/company/premier-funeral-management-group.
News Article | October 28, 2016
Calobrace & Mizuguchi Plastic Surgery Center (http://www.calobrace.com) is celebrating offering plastic surgery and medical spa services in Louisville, Kentucky with an open house on November 3 that includes exclusive specials and gifts. "This is a special event for our entire team because it gives us a chance to demonstrate our appreciation to all of our clients, both old and new," says Dr. M. Bradley Calobrace, one of the 3 plastic surgeons at the Louisville practice. "We've planned what should be an enjoyable afternoon and evening offering women and men the chance to discover the surgical and nonsurgical options available." The open house is scheduled to run from noon to 8 p.m. The practice is located at 2341 Lime Kiln Lane in Louisville. Directions are available on the plastic surgery center's website. Those wishing to attend should RSVP by October 28 by calling (502) 899-9982. Guests will also have a chance to meet Dr. Chet Mays, who joined Dr. Calobrace and Dr. Nana N. Mizuguchi earlier this year. Dr. Calobrace established the plastic surgery practice in 1997 and was joined in 2006 by Dr. Mizuguchi. Together, they focus on facial plastic surgery, body contouring procedures, and breast enhancement, including breast augmentation, at their offices in Lexington and Louisville. They also oversee the CaloSpa Rejuvenation Center, a medical spa offering a range of nonsurgical cosmetic procedures. The practice will be offering several specials at the open house: Additionally, guests can save 20% on select medi and day spa procedures, as well as, 20% on all skin care and body products sold at CaloSpa. "Besides the great deals, the event provides a relaxed setting at which our clients can mingle while sipping wine or champagne and enjoying hors d'oeuvres from Corbett's restaurant," Dr. Mizuguchi says. "This is truly a special occasion, and our team looks forward to seeing patients who have become like an extended family." Calobrace & Mizuguchi Plastic Surgery Center (http://www.calobrace.com) is a comprehensive surgical and non-surgical center, which includes the Calobrace Breast Center, the Calobrace Plastic Surgery Center, and the CaloSpa Rejuvenation Center. Both Dr. M. Bradley Calobrace and Dr. Nana M. Mizuguchi are certified by The American Board of Plastic Surgery and have received years of training in general surgery and plastic surgery. They have served as clinical instructors for University of Louisville's Division of Plastic and Reconstructive Surgery, and both perform a full range of treatments, including breast, body, and facial plastic surgery, for Louisville and Lexington, Kentucky, patients. Dr. Chet Mays joined the team in 2016 after completing a 6-year integrated plastic surgery residency at the University of Rochester. He earned his medical degree from the University of Louisville School of Medicine.
News Article | December 13, 2016
Specialists at Calobrace & Mizuguchi Plastic Surgery Center (http://www.calobrace.com) perform hair transplant surgery using the automated NeoGraft system at their Louisville and Lexington, Kentucky locations for patients concerned about premature hair loss. "Our practice is the first in Kentucky to offer the NeoGraft hair restoration system," Dr. M. Bradley Calobrace says. "NeoGraft is a game-changer for patients who want hair transplant surgery." NeoGraft is considered a breakthrough because its computer-assisted handpiece uses pneumatic pressure to harvest individual hair follicles from the back of a patient's head. Hair on the back and sides of the head is genetically programmed to continue growing, even in a person with hair loss. Hair with this genetic programming is then meticulously implanted in the balding area. Before NeoGraft came on the market, this technique -- called follicular unit extraction (FUE) -- was performed manually. It was effective, but quite tedious. "We have a certified NeoGraft technician available at our plastic surgery practice in Louisville," Dr. Calobrace says. "Patients favor NeoGraft over other hair restoration techniques because it's the least invasive method available and it leaves no visible scars." The alternative to FUE hair restoration is a technique called follicular unit transplantation, which is sometimes called the "strip method" because a narrow strip of the scalp is surgically removed from the back of the head. Follicles are then harvested from the strip. This method is less popular because it requires an incision, which results in a visible scar for men or women who want to wear their hair short. The most common reason both men and women start going bald is a genetic condition called androgenetic alopecia (it's also called male pattern baldness when experienced by men). It typically affects the top of the head and occurs when a testosterone derivative called DHT attacks hair follicles, causing hair loss. Almost 50% of American men and about 20% of American women experience hair loss. People who want hair transplant surgery are typically self-conscious about going bald, but until recently the hair restoration procedures available didn't produce satisfying results. NeoGraft has changed that. "The days of 'hair plugs' that looked obvious and unnatural are long gone," Dr. Nana N. Mizuguchi says. "It is very difficult to determine whether someone underwent hair transplant surgery with NeoGraft. The hair grows in a natural direction and looks like natural hair — because that's exactly what it is." Calobrace & Mizuguchi Plastic Surgery Center (http://www.calobrace.com) is a comprehensive surgical and non-surgical center, which includes the Calobrace Breast Center, the Calobrace Plastic Surgery Center, and the CaloSpa Rejuvenation Center. Both Dr. M. Bradley Calobrace and Dr. Nana M. Mizuguchi are certified by The American Board of Plastic Surgery and have received years of training in general surgery and plastic surgery. They have served as clinical instructors for University of Louisville's Division of Plastic and Reconstructive Surgery, and both perform a full range of treatments, including breast, body, and facial plastic surgery, for Louisville and Lexington, Kentucky, patients.
News Article | October 28, 2016
Calobrace & Mizuguchi Plastic Surgery Center (http://www.calobrace.com), which features 2 of the leading plastic surgeons in the Louisville and Lexington, Kentucky area, recently added Dr. Chet Mays to the practice. "We're excited to welcome a plastic surgeon with Dr. Mays' impressive background to our team," says Dr. Bradley Calobrace, who first met Dr. Mays when he was a third-year medical student enrolled in his course. "Dr. Mays blends exceptional skill with a passion for plastic surgery that stood out even when he was a University of Louisville medical school student." Dr. Mays is a Somerset native who graduated summa cum laude from the University of Louisville and went on to earn his medical degree at the University of Louisville School of Medicine. He completed a 6-year integrated plastic surgery residency in New York at the University of Rochester, where he had the opportunity to train at some of the most prestigious institutions in the nation, such as Johns Hopkins, Memorial Sloan Kettering Cancer Center, and Manhattan Eye, Ear, and Throat Hospital. His father and 3 brothers are also surgeons, and Dr. Mays decided early on to follow in their footsteps. "I'm very grateful for the opportunity to practice here at home in Kentucky and join Dr. Calobrace and Dr. Mizuguchi," Dr. Mays says. "The chance to work alongside 2 exceptional plastic surgeons is really a dream come true. I'm honored to be able to work with someone who has had such a profound influence on my career." Dr. Calobrace established the plastic surgery practice and was joined by Dr. Nana N. Mizuguchi in 2006. Together, they focus on facial plastic surgery, body contouring procedures, and breast enhancement, including breast augmentation, at their offices in Lexington and Louisville. They also oversee the CaloSpa Rejuvenation Center, a medical spa offering a range of nonsurgical cosmetic procedures. Dr. Calobrace believes that the addition of Dr. Mays will expand the capabilities of the practice, in a way that complements what they have already built. "Dr. Mays is not only a talented surgeon, but his compassion and desire to work with patients to provide the desired results fits in with the philosophy we've established over the years," Dr. Calobrace says. "His personality, or bedside manner, is one that helps patients feel comfortable." Calobrace & Mizuguchi Plastic Surgery Center (http://www.calobrace.com) is a comprehensive surgical and non-surgical center, which includes the Calobrace Breast Center, the Calobrace Plastic Surgery Center, and the CaloSpa Rejuvenation Center. Both Dr. M. Bradley Calobrace and Dr. Nana M. Mizuguchi are certified by The American Board of Plastic Surgery and have received years of training in general surgery and plastic surgery. They have served as clinical instructors for University of Louisville's Division of Plastic and Reconstructive Surgery, and both perform a full range of treatments, including breast, body, and facial plastic surgery, for Louisville and Lexington, Kentucky, patients. Dr. Chet Mays joined the team in 2016 after completing a 6-year integrated plastic surgery residency at the University of Rochester. He earned his medical degree from the University of Louisville School of Medicine.
Tozaki M.,Breast Center
Magnetic Resonance in Medical Sciences | Year: 2011
Proton magnetic resonance (MR) spectroscopy (MRS) of the mammary gland region has customarily been used in basic research but is now commonly performed in clinical practice as MR techniques have improved. To debate its usefulness in a variety of fields and ultimately grade the timing of its use, a symposium entitled "Clinical Application and the Latest Technology of MRS-Timing of the Addition of MRS" was presented in 2009 at the 37th Annual Meeting of the Japanese Society for Magnetic Resonance in Medicine (JSMRM). MRS timing was classified into 3 grades according to when its addition: is always better, Grade 1; will sometimes be effective, Grade 2; and can provide only supplemental information, Grade 3. We describe the content of the meeting session on "Timing of the Addition of MRS in the Breast Cancer Field," explain the reasons for the timing classifications, and review previous papers.
Tozaki M.,Breast Center
Breast Cancer | Year: 2013
There has been dramatic progress in MRI technology during the past 20 years, and the rate of detection and diagnostic accuracy in regard to intraductal carcinoma and ductal carcinoma in situ (DCIS) have been increasing. First, we present MRI images of intraductal carcinomas and the terminology in the second edition of the BI-RADS-MRI to describe them. Next, we examined the data in our institution in regard to the following: (1) the DCIS detection rate, (2) the proportions of breast cancer and DCIS in MR-guided vacuum-assisted biopsies (VAB), (3) evaluation of the extent of intraductal carcinoma, and (4) diagnosis of extension of intraductal carcinoma into the nipple. MR images were acquired by performing a 1-min interval dynamic study with a 1.5-T MR scanner. The same radiologist evaluated the MRI in all of the cases. MR-guided VAB was performed by using a commercially available biopsy system. (1) The DCIS detection rate was 95% (148/156), and the DCIS lesions that MRI was unable to detect were low grade in 5 cases, intermediate grade in 2 cases, and high grade in 1 case. (2) The proportion of MR-guided VAB specimens that were breast cancer was 36% (71/200), and the proportion of breast cancers that were DCIS was 82% (58/71). (3) The proportion of margin-positive specimens in the 100 breasts in which breast-conserving surgery was performed was 11% (11/100), and the proportion in which MRI was the cause of the margin being positive was a mere 4% (4/100). (4) The positive predictive value of periductal enhancement and linear enhancement for a diagnosis of intraductal extension into the nipple was 83% (10/12) and 43% (3/7), respectively. Their negative predictive value was 100% (58/58). We concluded that MRI is a very useful examination for the diagnosis of intraductal carcinoma, and that it is important to become thoroughly familiar with the BI-RADS-MRI terminology and accurate interpretation methods. © 2011 The Japanese Breast Cancer Society.
Tozaki M.,Breast Center |
Fukuma E.,Breast Center
Acta Radiologica | Year: 2011
Background: ShearWave TM Elastography (SWE) provides a quantitative measurement of tissue stiffness and may improve characterization of breast masses. However, the significance of Young's modulus measurements and appropriate SWE evaluation criteria has not been established yet. Purpose: To assess the usefulness of the pattern classification and Young's modulus measurements in the differential diagnosis between benign and malignant solid breast masses. Material and Methods: Ninety-six patients (age range 18-84 years, mean 54 years) with 100 solid breast masses who underwent tissue sampling after a US examination were analyzed. We tried to create a visual pattern classification based on the SWE images. After classifying the visual patterns, the Young's modulus of the lesions was measured in every case. Results: It was possible to classify the images into four patterns by the visual evaluation: no findings (coded blue homogeneously; Pattern 1), vertical stripe pattern artifacts (Pattern 2), a localized colored area at the margin of the lesion (Pattern 3), and heterogeneously colored areas in the interior of the lesion (Pattern 4). There were 17 Pattern 1 lesions, 14 Pattern 2 lesions, 20 Pattern 3 lesions, and 49 Pattern 4 lesions. When Patterns 1 and 2 were assumed to be benign, and Patterns 3 and 4 were assumed to be malignant, the sensitivity and specificity were 91.3% (63/69) and 80.6% (25/31), respectively. The mean Young's modulus measurements of the benign and the malignant lesions were 42 kPa and 146 kPa, respectively (P <0.0001). No significant differences were found between benign and malignant lesions in Pattern 3. In Pattern 4, however, the Young's modulus of the benign lesions (50 kPa) was lower than the smallest Young's modulus of malignant lesions (61 kPa). Conclusion: The visual pattern classification and adding Young's modulus measurements may improve characterization of solid breast masses.
News Article | December 2, 2016
ATLANTA, Dec. 2, 2016 /PRNewswire/ -- Quantum Radiology's Mobile Breast Center (QR MBC) brings cutting-edge breast screening and expert radiologist interpretation directly to women at the workplace, thereby maximizing convenience and compliance. QR MBC partners with corporations, such as...