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Gorakhpur, India

Singh K.,Child Nutrition and Development Programme | Badgaiyan N.,Child Nutrition and Development Programme | Ranjan A.,Child Nutrition and Development Programme | Dixit H.O.,National Rural Health Mission | And 3 more authors.
Indian Pediatrics | Year: 2014

Objective: To assess the effectiveness of facility-based care for children with severe acute malnutrition (SAM) in Nutrition Rehabilitation Centers (NRC). Design: Review of data. Setting: 12 NRCs in Uttar Pradesh, India. Participants: Children admitted to NRCs (Jan 1, 2010 - Dec 31, 2011). Intervention: Detection and treatment of SAM with locally-adapted protocols. Outcomes: Survival, default, discharge, and recovery rates. Results: 54.6% of the total 1,229 children admitted were boys, 81.6% were in the age group 6-23 months old, 86% belonged to scheduled tribes, scheduled castes, or other backward castes, and 42% had edema or medical complications. Of the 1,181 program exits, 14 (1.2%) children died, 657 (47.2%) children defaulted, and 610 (51.7%) children were discharged The average (SD) weight gain was 12.1 (7.3) g/kg body weight/day and the average (SD) length of stay was 13.2 (5.6) days. 206 (46.8%) children were discharged after recovery (weight gain ≥15%) while 324 (53.2%) were discharged, non-recovered (weight gain <15%) Conclusions: NRCs provide life-saving care for children with SAM; however, the protocols and therapeutic foods currently used need to be improved to ensure the full recovery of all children admitted. © 2014 Indian Academy of Pediatrics.

Poonam T.,Pharmacy U.T.U | Prem Prakash G.,BRD Medical College | Vijay Kumar L.,Sagar Herbal and Research Center
American Journal of Pharmacology and Toxicology | Year: 2013

Now a day's people use herb or herbal remedies along with their medication in long term treatment of various disease. Concomitant use of herb and drug can interact with each other may cause herb drug interaction. The present study was designed to investigate the possible herb drug interaction between Momordica Chrantia Fruit Juice (MCFJ) and metformin. Metformin was given orally in two different doses of 50 mg kg-1 and 100 mg kg-1. Momordica chrantia fruit juice was administered at a dose of 20 mL kg-1. The Blood glucose was estimated at 0, 7, 14, 21 and 28 days. Body weight of the rats of all the groups was recorded before and after the study period of 28 days. All the treatment shows significant (p<0.01) hypoglycemic effect. The hypoglycemic effect observed with combination of metformin and MCFJ was more than either drug alone. MCFJ alone or also in combination with metformin improve the body weight of diabetic rats. It is concluded that MCFJ along with metformin produce synergistic effect which may be beneficial or harmful so patients should take care when taking MCFJ along with metformin. © 2013 Science Publication.

Bhatt G.C.,PGIMER | Sharma T.,LLRM Medical College | Kushwaha K.P.,BRD Medical College
Journal of Pediatric Neurosciences | Year: 2012

Japanese encephalitis (JE) and malaria would coexist in the areas where both illnesses are endemic with overlapping clinical pictures, especially in a case of febrile encephalopathy with hepatosplenomegaly. However, there are no published data till date showing concurrent infection of these two agents despite both diseases being coendemic in many areas. We report a case of concurrent infection of JE and mixed plasmodium infection, where the case, initially diagnosed as cerebral malaria did not improve on antimalarials and alternative diagnosis of JEV encephalitis was thought which was confirmed by a serological test. To the best of our knowledge, this is the first case report of concurrent Japanese encephalitis with mixed plasmodium infection. We report a case of 3-year-old male child, who presented with febrile encephalopathy with hepatosplenomegaly. Based on a rapid diagnostic test and peripheral smear examination, a diagnosis of mixed P.Vivax and P.falciparum infection was made and the patient was treated with quinine and doxycycline. However, besides giving antimalarials the patient did not improve and an alternative diagnosis of JE was considered as the patient was from the endemic zone of Japanese encephalitis. Cerebrospinal fluid (CSF) of the patient was sent for a virological study which came out to be positive for JE IgM in CSF, which is confirmatory of JE infection. In a patient with febrile encephalopathy with hepatosplenomegaly especially in areas coendemic for JE and malaria, the possibility of mixed infection should be kept in mind.

Singh Y.,BRD Medical College
Rawal Medical Journal | Year: 2012

Multiple Small bowel diverticula is an uncommon entity, the disease is usually asymptomatic and often diagnosed when complicated. A triad of epigastric pain, abdominal discomfort and flatulence one or two hours after meal (Edwards triad) are presenting features. The diagnosis must be considered in a patient with unexplained malabsorption and anemia with Edwards triad.

Poonam T.,UTU | Prakash G.P.,BRD Medical College | Kumar L.V.,Sagar Herbal and Research Center
Drug Metabolism and Drug Interactions | Year: 2013

Background: The use of herbs with allopathic medicines increases the possibility of herb-drug interaction, which may either be beneficial or harmful. Therefore, the present study was undertaken to determine the interaction of glibenclamide, a sulfonylurea, with the aqueous extract of garlic (Allium sativum), an herb used widely as an antidiabetic agent. Methods: The interaction was evaluated by an acute study, chronic study, oral glucose tolerance test, and body weight estimation in streptozotocin-induced diabetic rats. Glibenclamide was given orally at two different doses of 0.25 and 0.5 mg/kg, and A. sativum extract (ASE) was administered at the dose of 500 mg/kg. Blood glucose level and body weight estimation were carried out at various intervals. Results: The hypoglycemic effect observed with combinations of glibenclamide and ASE was greater than either of the drug given alone. Combined treatments of glibenclamide and ASE resulted in higher increase in body weight than alone treatments. Conclusions: We conclude that ASE shows a synergistic effect with glibenclamide. This could be important in reducing the dose of glibenclamide to achieve an enhanced therapeutic effect with minimal side effects.

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