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Malang, Indonesia

University of Brawijaya , established in 1963 and located in Malang, is a state university in Indonesia. UB is a leading university in Indonesia with more than 30,000 students in degrees ranging from the diploma programs , Bachelor’s degree program, Master’s degree program, Doctoral degree program, and Medical Specialist program in 11 faculties.UB campus is in the city of Malang, East Java, in a strategic location easily reached by public transportation. The campus has a pleasant climate with many trees and the cool air of Malang at 475 meters elevation. Wikipedia.

This experiment was conducted to know the production performance and organs condition of broiler fed supplemented with red ginger (Zingiber officinale Rose) as phytobiotic, Two hundred broiler chickens of 5 days old were divided into 5 different feed treatment groups, namely: control feed without red ginger (R-0) and treatment feeds (R-0.5, R-1.0, R-1.5 and R-2.0 which were control feed with 0.5, 1.0, 1.5 and 2.0% red ginger, respectively). Each group was divided into 5 sub groups as replication, consisted of 8 chickens each. The chickens were raised for five weeks. All chickens were weekly weighed and feed consumption was daily measured in each sub-group. After 35 days old, the chickens were slaughtered then the breast muscle, liver, kidney and proventriculus were taken for histological observation. Data obtained were subjected to analysis of variance of Completely Randomized Design one way classification and Duncan's New Multiple Range Test. The result showed that the production performance of broiler fed supplemented with red ginger showed higher body weight (p<0.05), lower total feed intake (p<0.05). The use of 2% red ginger in the ration gave higher body weight, lower total feed intake and lowest changeover on the muscle, liver, kidney and proventriculus conditions. © Asian Network for Scientific Information, 2010. Source

Widoretno W.,Brawijaya University
Plant Cell, Tissue and Organ Culture

Patchouli (Pogostemon cablin Benth.) is one kind of plant from Indonesia which is producing oil. In vitro induction of tetraploid in Patchouli plant and cytological and morphological characterization were conducted. Induced polyploidy was done by culturing leaf explant on MS medium added with a varying concentration of colchicine. It was observed that colchicine on MS medium mostly affect to growth of explant and shoot regeneration. Tetraploid plants were determined by observation of chromosome number. The tetraploid plants have chromosome number (2n = 4x = 128), twice higher than those of diploid plants (2n = 2x = 64). The tetraploid plants exhibited much larger stomata size but less than diploid plants. The tetraploid plants also showed more glandular hairs than diploid plants. Significant different in morphological characters between the diploid and tetraploid plants were noted. Leaf size and stem diameter of the tetraploids plant are larger than the diploid plants. In this study, the tetraploids Patchouli have a promising potential as a superior variety. © 2016 Springer Science+Business Media Dordrecht Source

to examine the role of diltiazem in the prevention of VSMC apoptosis exposed to high glucose through inhibition of LOX-1 expression. we performed experimental study on the primary culture of VSMCs. Expression LOX-1, and Caspase-3 activity (a key regulatory protease at which many signaling pathways merge for the execution of apoptosis) were measured by Elisa. Data were expressed as mean ± SEM. The statistical significance was assessed by one-way analysis of variance (ANOVA) followed by post hock analysis by Turckey test, p<0.05 was considered statistically significant. chronic exposed VSMC to high glucose concentration (25 mM), increase cytosolic Ca++ concentration (3127 ± 413.89 v.s. 2011.81 ± 410.93 unit/cell, p<0.01), expression of LOX-1 ((506.80 ± 10.47 v.s. 458.40 ± 36.49 ng/ml, p<0.05), and caspase-3 activity (129.98 ± 5.97 v.s. 114.73 ± 10.84%, p<0.05) respectively, compare exposed to 5mM glucose concentration. LOX-1 was related to caspase-3 activity, pre-treated with inhibitor LOX-1 activity, k-carragenan before being exposed to glucose 25 mM, prevents the increasing of caspase-3 activity (96.41 ± 5.11 v.s. 129.98 ± 5.98 %, p<0.01). Pre incubation with 10μM of diltiazem before being exposed to 25 mM glucose concentration significantly inhibits the elevation of cytosolic Ca++ concentration (2149.61 ± 339.49 v.s. 3127 ± 413.89 unit/cell, p<0.01), LOX-1 expression (468,60 ± 14.44 v.s. 506.80 ± 10.47 ng/ml, p < 0.05), and caspase-3 activity (82.50 ± 9.90 v.s. 129.98 ± 5.97%, p<0.01). overall, these results demonstrate that high glucose induces VSMCs apoptosis through caspase-3 pathway. This effect appears to be inhibited by diltiazem through decreasing LOX-1 expression and activity. Source

Yusainy C.,Brawijaya University | Lawrence C.,University of Nottingham
Consciousness and Cognition

Many experiments have shown that one's ability to refrain from acting on aggressive impulses is likely to decrease following a prior act of self-control. This temporary state of self-control failure is known as ego-depletion. Although mindfulness is increasingly used to treat and manage aggressive behaviour, the extent to which mindfulness may counteract the depletion effect on aggression is yet to be determined. This study (N= 110) investigated the effect of a laboratory induced one-time mindfulness meditation session on aggression following depletion. Aggression was assessed by the intensity of aversive noise blast participants delivered to an opponent on a computerised task. Depleted participants who received mindfulness induction behaved less aggressively than depleted participants with no mindfulness induction. Mindfulness also improved performance on a second measure of self-control (i.e., handgrip perseverance); however, this effect was independent of depletion condition. Motivational factors may help explain the dynamics of mindfulness, self-control, and aggression. © 2014 Elsevier Inc. Source

to determine the relationships between vitamin D and CCR4 expression on Treg, and Treg migratory capacity in SLE patients in Indonesia. vitamin D level assesment, CCR4 expression on Treg and Treg migratory capacity were performed on 41 SLE patients and 20 healthy controls. Serum vitamin D levels were measured by ELISA (Cusabio). The expression of CCR4 on Treg was detected by flow cytometry and Treg migratory capacity was performed in chemotaxis chamber using CCR4 ligands, TARC and MDC, and subsequently analyzed by flow cytometry using FACS Calibur (Becton Dickinson). The number of migrated Treg is the ratio of CD4+CD25+CCR4+ cells number in lower chamber of chemotaxis compared to the total number of CD4+CD25+CCR4+ cells before migration, and stated in percentage. vitamin D levels were significantly lower in SLE patients compared with healthy controls (p=0.000). The vitamin D levels were positively correlated to the percentage of migrated Treg toward TARC (p=0.015) and MDC (p=0.000), but there was no difference in Treg CCR4 expression between SLE patients and healthy controls. low vitamin D levels cause reduced Treg migratory capacity in SLE patients and healthy people. This influence occurs through other factors rather than CCR4 expression. Source

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