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Chen Z.,Wuhan University | Chen Z.,Wuhan Medical Health Center for Women and Children | Wang M.,Branch Hospital in Fengxian of Shanghai | Xiang Q.,Wuhan Medical Health Center for Women and Children | And 2 more authors.
Cell Biology International | Year: 2013

The discovery of adult cardiac progenitor cells (CPCs) provides a promising way for treating heart disease; however, their surface characteristics that play a critical role in regulating their maintenance, self-renewal,migration, and differentiation have not been fully investigated. One subpopulation of Dolichos biflorus agglutinin (DBA)-positive cells was identified in the heart of adult mice. Flow cytometry showed that 3.7% of heart cells could be labeled by FITC conjugated DBA. BrdU pulse-chase showed that 55- 75% of DBA+ cells were CPCs. Evidences from 5-FU-induced myelosuppression along with BrdU pulse-chasing suggests that DBA-positive cells are proliferative. Furthermore, DBA positive cells display a cologenic appearance in vivo. Our findings suggest that DBA-positive cells in the heart of adult mouse contained a subset of CPCs, and DBA reactivity is one novel surface characteristic on CPCs. © 2013 International Federation for Cell Biology. Source


Sun Z.-L.,Branch Hospital in Fengxian of Shanghai | Zhang Y.,Shanghai JiaoTong University | Wan A.-H.,Branch Hospital in Fengxian of Shanghai | Zhang X.-L.,Branch Hospital in Fengxian of Shanghai | Feng J.,Branch Hospital in Fengxian of Shanghai
Journal of Asian Natural Products Research | Year: 2011

Constituents of the fruits of Rubus corchorifolius were investigated. A new compound, namely rubusin A (1), along with three known compounds, was isolated and characterized. Among them, the new compound exhibited significant activity against kidney deficiency, and quercetin and kaempferol were isolated from the fruits of R. corchorifolius for the first time. © 2011 Taylor & Francis. Source

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