Time filter

Source Type

Fengxian, China

Lv Z.,Shanghai University | Zhang Y.,Shanghai University | Zhang M.,Shanghai University | Chen H.,Shanghai University | And 4 more authors.
European Journal of Medicinal Chemistry

We have synthesized a series of novel 2-pyridone derivatives with 1,2,3-triazole and evaluated their antitumor activities in vitro. The bioassays showed that the majority of the resultant compounds exerted inhibitory effects on six human cancer cell lines to various extents. In particular, compound 10k showed the best anti-tumor activities (IC50 values of A549, HeLa and SW480 cancer cell lines were 0.86 ± 0.17 mM, 0.54 ± 0.23 mM and 0.21 ± 0.13 mM, respectively). © 2013 Elsevier Masson SAS. All rights reserved. Source

Sun Z.-L.,Branch Hospital in Fengxian | Zhang M.,Branch Hospital in Fengxian | Zhang J.-F.,Branch Hospital in Fengxian | Feng J.,Branch Hospital in Fengxian

Three novel compounds with spiro-5, 6-lactone ring skeleton has been isolated from the fermentation broth of Massrison sp. which could be isolated repeatedly from wild Rehmannia glutinosa. Psetariae oryza P-2b was applied to guide fractionation of bioactive compounds produced by Massrison sp. The molecular structures were established by a variety of one- and two-dimensional NMR experiments and the compounds with similar skeleton were reported for the first time from endophytic fungi of terraneous plant. Antifungal and cytotoxic activities of the compounds were tested, compounds 2 and 3 displayed stronger antifungal and cytotoxic activities. The compounds have the potential to be antibiotic against fungal pathogens and tumor cells. © 2011 Elsevier GmbH. Source

Discover hidden collaborations