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Seoul, South Korea

Kang Y.K.,BrainOn Inc. | Hong S.K.,Panaxan. Corporation
Korean Journal of Microbiology and Biotechnology | Year: 2014

This study examined the efficacies of Cynanchum wilfordii and Phlomis umbrosa extracts on serum insulin like growth factor-I (IGF-I) and bone growth by raising rats in vivo. C. wilfordii and P. umbrosa extracts significantly increased serum IGF-I by 42% and 22% than the control, respectively. Treatment with α-amylase when manufacturing these extracts remarkably increased the concentration of IGF-I by 63% and 36% above the control, respectively. This meant that these extracts, especially α-amylase treated extracts, maintained a higher level of IGF-I secretion in the treated groups. In addition, increases of 6% in femur length were found after 8 weeks of oral administration with these extracts. These results indicate that C. wilfordii and P. umbrosa extracts have beneficial effects on bone growth via IGF-I. © 2014, The Korean Society for Microbiology and Biotechnology. Source


Kang Y.K.,BrainOn Inc. | Lee W.,Inha University | Kang B.,BrainOn Inc. | Kang H.,BrainOn Inc.
Journal of Microbiology and Biotechnology | Year: 2013

Although enzyme-hydrolyzed silk fibroin has been reported to enhance cognitive function before, it has been still unknown which peptides can improve memory. Here we report that amino acid sequences of three novel peptides were identified from fibroin hydrolysate. Fibroin hydrolysate was obtained by hydrolysis with protease after partial hydrolysis with 5M CaCl2. Synthesized peptides derived from these sequences improved scopolamine-induced memory impairments in mice. We confirmed this hydrolysate had effects that improved learning and memory abilities by performing the Rey-Kim test. From this hydrolysate of silk fibroin, amino acid sequences of eight peptides were identified by LC-MS/MS. Three peptides (GAGAGTGSSGFGPY, GAGAGSGAGSGAGAGSGAGAGY, and SGAGSGAGAGSGAGAGSGA) were synthesized to investigate whether they could improve memory. Passive avoidance test and Morris water maze test were performed, and all peptides showed memory-enhancing abilities on scopolamine-induced memory impairments in mice. In this study, we identified three novel peptides that could improve memory, and that silk fibroin hydrolysate was a mixture of various active peptides that could enhance memory. © 2013 by The Korean Society for Microbiology and Biotechnology. Source

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