National Brain Research Institute

Gurgaon, India

National Brain Research Institute

Gurgaon, India
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Devi M.G.,Institute of Human Behavior and Allied science | Sharma A.,Government of India | Mohanty S.,All India Institute of Medical Sciences | Jain N.,National Brain Research Institute | And 7 more authors.
Annals of Indian Academy of Neurology | Year: 2016

Introduction: Neurologists in their clinical practice are faced with inquiries about the suitability of stem cell approaches by patients with a variety of acute and chronic (namely neurodegenerative) disorders. The challenge is to provide these patients with accurate information about the scope of stem cell use as well as at the same time, empowering patients with the capacity to make an autonomous decision regarding the use of stem cells. Methods: The Indian Academy of Neurology commissioned an Expert Group Meeting to formulate an advisory to practicing neurologists to counsel patients seeking information and advice about stem cell approaches. Results and Conclusions: In the course of such counselling, it should be emphasized that the information provided by many lay websites might be unsubstantiated. Besides, standard recommendations for the stem cell research, in particular, the application of several layers of oversight should be strictly adhered in order to ensure safety and ethical use of stem cells in neurological disorders.


PubMed | Cellecta, Inc., Bose Institute of India, Jadavpur University, National Brain Research Institute and 2 more.
Type: | Journal: Oncotarget | Year: 2016

Aggregation of proteins with the expansion of polyglutamine tracts in the brain underlies progressive genetic neurodegenerative diseases (NDs) like Huntingtons disease and spinocerebellar ataxias (SCA). An insensitive cellular proteotoxic stress response to non-native protein oligomers is common in such conditions. Indeed, upregulation of heat shock factor 1 (HSF1) function and its target protein chaperone expression has shown promising results in animal models of NDs. Using an HSF1 sensitive cell based reporter screening, we have isolated azadiradione (AZD) from the methanolic extract of seeds of Azadirachta indica, a plant known for its multifarious medicinal properties. We show that AZD ameliorates toxicity due to protein aggregation in cell and fly models of polyglutamine expansion diseases to a great extent. All these effects are correlated with activation of HSF1 function and expression of its target protein chaperone genes. Notably, HSF1 activation by AZD is independent of cellular HSP90 or proteasome function. Furthermore, we show that AZD directly interacts with purified human HSF1 with high specificity, and facilitates binding of HSF1 to its recognition sequence with higher affinity. These unique findings qualify AZD as an ideal lead molecule for consideration for drug development against NDs that affect millions worldwide.


PubMed | Indian Spinal Injuries Center, All India Institute of Medical Sciences, National Institute of Mental Health and Neuro Sciences, Government of India and 6 more.
Type: Journal Article | Journal: Annals of Indian Academy of Neurology | Year: 2016

Neurologists in their clinical practice are faced with inquiries about the suitability of stem cell approaches by patients with a variety of acute and chronic (namely neurodegenerative) disorders. The challenge is to provide these patients with accurate information about the scope of stem cell use as well as at the same time, empowering patients with the capacity to make an autonomous decision regarding the use of stem cells.The Indian Academy of Neurology commissioned an Expert Group Meeting to formulate an advisory to practicing neurologists to counsel patients seeking information and advice about stem cell approaches.In the course of such counselling, it should be emphasized that the information provided by many lay websites might be unsubstantiated. Besides, standard recommendations for the stem cell research, in particular, the application of several layers of oversight should be strictly adhered in order to ensure safety and ethical use of stem cells in neurological disorders.


Eswaran S.V.,Regional Center for Biotechnology | Kaur D.,CSIR - Central Electrochemical Research Institute | Khamaru K.,Indian Central Salt and Marine Chemicals Research Institute | Prabhakar S.,Indian Institute of Chemical Technology | And 3 more authors.
Tetrahedron Letters | Year: 2016

Pyrolysis of azido-meta-meconine yields only a single product 1D, which has been characterized spectroscopically (1H NMR, 13C NMR, HSQC, DEPT & MS). These results reveal that the fused five-member lactone ring can influence the product selectivity. The DFT calculations suggest the formation of favourable oxazolidine intermediate compared to azirine (1Z) and ketenimine (1H) intermediates. The isodesmic analysis showed that the fused lactone aryl nitrene (1N) would have more strain to form azirine (1Z) intermediate than the corresponding aryl nitrene (1M). © 2016 Elsevier Ltd. All rights reserved.

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