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Utrecht, Netherlands

Stork A.C.J.,Rudolf Magnus Brain Center | Cats E.A.,Rudolf Magnus Brain Center | Vlam L.,Rudolf Magnus Brain Center | Heezius E.,UMC Utrecht | And 8 more authors.
Journal of Neuroimmunology | Year: 2016

Polyneuropathy associated with IgM monoclonal gammopathy (IgM-PNP) is a slowly progressive, sensorimotor neuropathy. It is assumed that complement activation contributes to IgM-PNP pathogenesis. We investigated whether innate differences in complement activity of the classical and mannose binding lectin (MBL) pathways are associated with IgM-PNP or its severity. We measured complement activity using ELISA and determinedMBL serumconcentrations andMBL gene polymorphisms in 83 patients and 83 healthy controls. We did not observe differences between IgM-PNP patients and healthy controls nor associations with different disease severities. Differences in innate complement activity are not likely to explain susceptibility to or severity of IgM-PNP. © 2015 Published by Elsevier B.V. Source

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