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Bradford, United Kingdom

Getgood A.,University of Cambridge | Bollen S.,Bradford Teaching Hospitals NHS Trust
Cell and Tissue Banking | Year: 2010

Tendon and osteochondral allograft are key requirements for reconstructive orthopaedic surgery. Their successful use has been published repeatedly, however, they are associated with potential significant problems, which both patients and surgeons should be aware of. This review highlights the advantages and disadvantages associated with the clinical use of both tendon and osteochondral allograft. Particular emphasis is paid to graft immunogenicity, viability, incorporation and disease transmission, with specific examples from the literature illustrating each point. © 2009 Springer Science+Business Media B.V. Source

Blakey C.M.,Sheffield Teaching Hospital NHS Trust | Rennison M.,University of Sheffield | Guy S.P.,Bradford Teaching Hospitals NHS Trust | Sutton P.M.,Sheffield Teaching Hospital NHS Trust
BMC Sports Science, Medicine and Rehabilitation | Year: 2013

Background: A novel method of fixation has been described for the treatment of pure depression fractures of the lateral tibial plateau. Fracture fragments are elevated through a reamed transtibial tunnel. An interference screw is then passed into the tunnel to buttress fracture fragments from beneath. This method of fixation has perceived benefits but there have been no studies to demonstrate that the technique is biomechanically sound. The aim of our study is to compare traditional parallel, subchondral screw fixation with the use of an interference screw, assessing maintenance of fracture reduction following simulated post-operative loading, and overall construct strength. Methods: Depression fractures of the lateral tibial plateau were simulated in 14 porcine knees. Fracture fragments were elevated through a reamed transtibial tunnel and samples were randomly assigned to a fixation method. 7 knees underwent traditional fixation with parallel subcortical cannulated screws, the remainder were stabilized using a single interference screw passed through the transtibial tunnel. Following preloading, each tibia was cyclically loaded from 0 to 500 Newtons for 5,000 cycles using a Nene testing machine. Displacement of the depressed fracture fragments were measured pre and post loading. Samples were then loaded to failure to test ultimate strength of each construct. Results: The depression displacement of the fractures fixed using cannulated screws was on average 0.76 mm, in comparison to 0.61mm in the interference screw group (p=0.514). Mechanical failure of the cannulated screw constructs occurred at a mean of 3400 N. Failure of the transtibial interference screw constructs occurred at a mean of 1700 N (p<0.01). In both groups the mechanism of ultimate failure was splitting of the tibial plateau. Conclusion: These results demonstrate the increased biomechanical strength of parallel, cannulated screws for depression fractures of the tibial plateau, however the use of a transtibial interference screw may be a viable method of fixation under physiological loads. © 2013 Blakey et al.; licensee BioMed Central Ltd. Source

Keane D.F.,St Jamess Hospital | Roberts G.,St Jamess Hospital | Bem C.,Bradford Teaching Hospitals NHS Trust | Hutchinson I.,Airedale NHS Trust
Nuclear Medicine Communications | Year: 2013

Introduction: With the advent of minimally invasive surgery to treat hyperparathyroidism, preoperative imaging of parathyroid glands has become routine practice. Scintigraphy and ultrasound are the two most common imaging techniques. Despite this, published sensitivities for scintigraphy vary enormously, and there is a multitude of protocols performed. This investigation compares the accuracies of planar subtraction and multiple washout images in the same group of patients. METHODS: We followed up 190 consecutive patients who underwent a combined subtraction and washout scintigraphy protocol and compared the results against surgical outcomes, taken as the gold standard. Technetium-99m sestamibi images were acquired at 5 min and at 1, 2 and 3 h, followed by a technetium-99m pertechnetate image for subtraction. Sixty-four of these patients also underwent ultrasound imaging for localization. The relative value of each part of the protocol in localizing adenomas was compared. RESULTS: The overall accuracy of this combined protocol for correct localization of both the side and axial level of parathyroid adenomas was 81% (90% when considering the side of the adenoma alone). Of all the nuclear medicine images produced, subtraction was the most useful. The 1 and 2 h washout images were comparable but the 3 h image added no value. The accuracy of ultrasound imaging was 55% for the side and pole and 60% for the side of the adenoma. CONCLUSION: For optimal accuracy a planar parathyroid localization protocol should include subtraction and at least one washout image between 1 and 2 h after injection. Copyright © Lippincott Williams & Wilkins. Source

Mannan A.,Bradford Teaching Hospitals NHS Trust | Smith T.O.,University of East Anglia
Knee | Year: 2016

Background: Implant malposition in total knee arthroplasty (TKA) often results in unsatisfactory outcomes. Rotational malalignment leads to impaired patellar tracking, stability and joint biomechanics. Patient-specific instrumentation aims to improve three-dimensional implant positioning while reducing overall costs of instrumentation. Methods: A PRISMA compliant search of all relevant literature between 2000 and 2014 was performed. The primary outcome of interest was deviation from a neutral femoral and tibial axial alignment of patient-specific instrumentation (PSI) vs conventional instrumentation. Femoral rotation was measured with reference to the transepicondylar axis. Tibial rotation was reported with reference to the anterior tibial tuberosity and a "best fit" with the anterior tibial cortex. Results: Six randomised studies met the inclusion criteria reporting on a total of 444 knees. Computed tomography (CT) based PSI systems were used exclusively in three studies, and two further studies in association with magnetic resonance imaging (MRI). MRI was used exclusively in one study. Mean femoral rotation in the conventional group was: - 1.7 to 1.6° (vs - 1.7 to 1° in the PSI group). Meta-analysis demonstrated a significant treatment effect favouring PSI with increased accuracy in "three-degree outliers" with femoral rotation: Z = 2.07, P = 0.04. A single study reported tibial rotational outcomes with no significant difference demonstrated in conventional instrumentation vs PSI. Conclusions: This Level 1 meta-analysis demonstrates favourable femoral rotational alignment outcomes in PSI knee arthroplasty. Only limited data is available for tibial rotational outcomes. Further studies with standardised "gold-standard" measurement criteria are required to clarify tibial rotational outcomes in PSI TKA. Level of evidence: 1. © 2015 Elsevier B.V. Source

Agada F.,York Teaching Hospitals NHS Trust | Dawson D.,Bradford Teaching Hospitals NHS Trust | Sood S.,Bradford Teaching Hospitals NHS Trust
Australian Family Physician | Year: 2011

This article outlines two cases of snoring and obstructive sleep apnoea (OSA) secondary to parapharyngeal space tumours. Both patients were referred to a specialist sleep clinic where oropharyngeal masses were seen and biopsied. Both underwent surgery and this was curative of both their snoring and their OSA. Parapharyngeal space tumours are an extremely rare cause of OSA and snoring. However, all patients with OSA and snoring should have a full head and neck examination before referral; in rare cases this could enable early detection of a parapharyngeal space tumour. Source

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