Bracco Suisse SA

La Chaux-de-Fonds, Switzerland

Bracco Suisse SA

La Chaux-de-Fonds, Switzerland
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Patent
Bracco Suisse S.A. | Date: 2015-04-03

A solution for use with an ultrasound scanner is proposed. A corresponding method (A1-A15) comprises applying (A7) a measurement excitation signal, comprising ultrasound waves generated by varying a power level of the ultrasound scanner in a measurement range, with a transducer of the ultrasound scanner to a body-part of a patient comprising a contrast agent being pre-administered to the patient before performing the method, recording (A8) a measurement response comprising a level of a non-fundamental component of a measurement echo signal received in response to the measurement excitation signal, and determining (A9-A14) an estimate value according to a comparison between measurement data based on the measurement response and reference data based on a reference response; said determining an estimate value comprises: a) estimating (A11) a target power level required to apply a selected target acoustic pressure level to the body-part and/or estimating a further target acoustic pressure level applied to the body-part when a selected further target power level is set when the reference response is a calibration response expressing the level of said non-fundamental component of a calibration echo signal as a function of the acoustic pressure level in an in-vitro calibration structure comprising the contrast agent, and/or b) estimating (A13) a total acoustic attenuation occurring within the patient between the transducer and the body-part when the reference response is a further calibration response expressing the level of said non-fundamental component of the calibration echo signal as a function of the power level in the in-vitro calibration structure, and/or c) estimating (A14) a partial acoustic attenuation occurring within the patient between the body-part and a further body-part of the patient when the reference response is a further measurement response expressing the level of said non-fundamental component of a further measurement echo signal as a function of the power level in the further body-part.


Patent
Bracco Suisse SA | Date: 2017-02-15

A solution for use with an ultrasound scanner is proposed. A corresponding method (A1-A15) comprises applying (A7) a measurement excitation signal, comprising ultrasound waves generated by varying a power level of the ultrasound scanner in a measurement range, with a transducer of the ultrasound scanner to a body-part of a patient comprising a contrast agent being pre-administered to the patient before performing the method, recording (A8) a measurement response comprising a level of a non-fundamental component of a measurement echo signal received in response to the measurement excitation signal, and determining (A9- A14) an estimate value according to a comparison between measurement data based on the measurement response and reference data based on a reference response; said determining an estimate value comprises: a) estimating (A11) a target power level required to apply a selected target acoustic pressure level to the body-part and/or estimating a further target acoustic pressure level applied to the body-part when a selected further target power level is set when the reference response is a calibration response expressing the level of said non- fundamental component of a calibration echo signal as a function of the acoustic pressure level in an in-vitro calibration structure comprising the contrast agent, and/or b) estimating (A13) a total acoustic attenuation occurring within the patient between the transducer and the body-part when the reference response is a further calibration response expressing the level of said non-fundamental component of the calibration echo signal as a function of the power level in the in-vitro calibration structure, and/or c) estimating (A14) a partial acoustic attenuation occurring within the patient between the body-part and a further body-part of the patient when the reference response is a further measurement response expressing the level of said non- fundamental component of a further measurement echo signal as a function of the power level in the further body-part.


Patent
Dyax and Bracco Suisse SA | Date: 2015-12-02

A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.


Patent
Bracco Suisse S.A and Dyax | Date: 2015-04-17

The invention provides compositions and methods for therapeutic and diagnostic applications.


Patent
Bracco Suisse Sa | Date: 2014-02-26

Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.


Patent
Bracco Suisse S.A. | Date: 2016-06-01

Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.


Patent
Bracco Suisse Sa | Date: 2013-06-10

Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.


Patent
Bracco Suisse S.A. | Date: 2015-10-30

Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging.


Patent
Bracco Suisse SA | Date: 2013-07-23

Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.


Patent
Bracco Suisse S.A. | Date: 2015-12-28

The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles having respective peaks of non-linear echographic response differing by at least 2 MHz to each other, and preferably have respective size distributions with different median sizes. In particular, said preparations preferably have size distributions with respective D_(V50 )values differing from each other by at least 0.5 m, more preferably at least 1.0 m. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher. According to a preferred embodiment, at least 95% of the total volume of gas contained in said microvesicles, calculated on the population of microvesicles up to a diameter of 10 m, is contained in microvesicles having a diameter of 8 micron or less.

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