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La Chaux-de-Fonds, Switzerland

Patent
Bracco Suisse SA and Dyax | Date: 2013-12-17

The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K


Patent
Bracco Suisse Sa | Date: 2013-06-10

Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.


The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K


An embodiment of a segmentation solution for use in diagnostic imaging applications is proposed. A corresponding embodiment of a data-processing segmentation method comprises: providing a representation over a non-zero analysis time period of a body-part being perfused with a contrast agent, the representation comprising, for each location of a set of locations of the body-part, an indication of a response over the analysis time period of the location to an interrogation signal; calculating, for each selected location of a set of selected locations, the value of at least one statistical parameter of a statistical distribution of the response over the analysis time period of the selected location, the set of selected locations comprising all the locations or a part thereof; and segmenting the selected locations according to a comparison between the values of said at least one statistical parameter for the selected locations with at least one segmentation threshold.


Patent
Bracco Suisse S.A and Dyax | Date: 2015-04-17

The invention provides compositions and methods for therapeutic and diagnostic applications.

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