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Akkoc Y.,Ege University | Cinar Y.,Bozyaka Training and Research Hospital | Kismali E.,Ege University
International Journal of Rehabilitation Research | Year: 2012

The aim of the study was to compare urodynamic findings and upper urinary tract (UUT) abnormalities detected by ultrasonography in complete and incomplete suprasacral spinal cord injury (SCI) patients with neurogenic detrusor overactivity. Thirty-eight suprasacral SCI patients who underwent ultrasonography evaluation of the UUT and urodynamic investigation were evaluated retrospectively. The mean maximum detrusor pressure was 51.08+28.71 cmH 2O for the American Spinal Injury Association (ASIA)-A group and 61.42+30.93 cmH 2O for the ASIA-B-E group (P>0.05). The mean cystometric capacity was 269.38+139.98 for the ASIA-A group and 223.36+135.59 ml for the ASIA-B-E group (P>0.05). Abnormalities in the UUT were found in 15.4% of the complete SCI patients and 16% of the incomplete SCI patients (P>0.05). No differences were found in urodynamic parameters and UUT abnormalities between the complete and the incomplete suprasacral SCI patients. Therefore, incomplete SCI patients should be observed with the same caution as complete SCI patients. Copyright © 2012 Lippincott Williams &Wilkins.

Argon A.,Bozyaka Training and Research Hospital | Uyaroglu M.A.,Ege University | Nart D.,Ege University | Veral A.,Ege University | Kitapcioglu G.,Ege University
Acta Cytologica | Year: 2013

Objectives: Since malignant cells were first detected in the cerebrospinal fluid (CSF), numerous methods have been used for CSF examination. The cytocentrifugation and liquid-based cytology (LBC) methods are two of these. We aimed to investigate whether the results from the LBC method were different from the results of the cytological diagnosis of the CSF materials that were prepared using the cytocentrifugation method. Materials and Methods: A retrospective analysis was conducted using the pathological records of 3,491 (cytocentrifugation on 1,306 and LBC on 2,185) cytological specimens of CSF which were diagnosed over a 4-year period between January 2007 and December 2011. The Fisher exact test was used to compare the results of the LBC and cytocentrifugation methods. Results: While there was a noticeable decrease in nondiagnostic diagnosis and a slight decrease in suspicious diagnosis, there was an increase in malignant and benign diagnosis with the LBC method in comparison to the centrifugation method. Statistically, the decrease in nondiagnostic diagnosis was considered significant (p < 0.0001). Discussion: The LBC method seems like a better option than the cytocentrifugation method, because of many preparatory, screening and diagnostic advantages, especially in pathology departments where materials come from far away and large volumes are examined. © 2013 S. Karger AG, Basel.

Erol A.,Izmir Ataturk Training and Research Hospital | Delibas H.,Bozyaka Training and Research Hospital | Bora O.,Clinic of Psychiatry | Mete L.,Izmir Ataturk Training and Research Hospital
International Journal of Social Psychiatry | Year: 2015

Background: It is still unclear whether insight has a direct association with social functioning in schizophrenia, independent of its association with symptoms. Aim: This study aimed to investigate the relationship of insight and its dimensions with social functioning in schizophrenia. Methods: A total of 170 outpatients with schizophrenia were included in this study. All patients were evaluated with the Scale to Assess Unawareness of Mental Disorder (SUMD), Positive and Negative Syndrome Scale (PANSS) and Personal and Social Performance Scale (PSP). Patients with impaired insight and patients with unimpaired insight were compared for PSP score through independent samples t test. Pearsons correlation analysis was used to determine the correlations between study variables. Multiple stepwise linear regression analysis was used in order to determine the variables that predict social performance. Results: The PSP score of patients with impaired insight was significantly lower than that of patients with unimpaired insight. There were significant correlations between insight dimensions and PSP score. PANSS negative scale score, awareness of achieved effects of medication and awareness of anhedonia/asociality were significant predictors of social performance. Conclusion: Insight has a significant impact on social functioning in schizophrenia, and some, but not all, insight dimensions have direct impact on social performance, independent of their association with symptoms. © 2014 The Author(s).

Kebapcilar A.G.,Izmir Aegean Obstetrics and Gynecology Teaching Hospital | Taner C.E.,Izmir Aegean Obstetrics and Gynecology Teaching Hospital | Kebapcilar L.,Bozyaka Training and Research Hospital | Bozkaya G.,Bozyaka Training and Research Hospital
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2010

Objectives.This study was designed for evaluating coagulation parameters and low APGAR scores in pregnancies with intrahepatic cholestasis of pregnancy (ICP) vs. normal control pregnancies. Methods.We carried out a prospective casecontrol study by enrolling 40 women with ICP at the third trimester of pregnancy and 40 pregnant women without ICP. Results.Total bile acid levels (TBA), MPV, D-dimer, and umbilical artery systolic/diastolic ratio (UASDR) values were higher in women with ICP. Pregnancies complicated by low APGAR score exhibited significantly higher D-dimer levels than those of unimpaired fetal outcome in patients with ICP and control subjects. Levels of D-dimer were inversely correlated with 5′-Apgar score and positively associated with UASDR values in patients with ICP. Pregnancies that exhibited abnormal UASDR had higher total bile acid (TBA), D-dimer, MPV values and lesser 5′-Apgar score. In linear stepwise regression analyses, D-dimer independently and positively associated with UASDR, inversely associated with 5′-Apgar score in subjects with ICP; positively associated with mean platelet volume (MPV) values and inversely associated with 5′-Apgar score in all subjects. Conclusion.Patients with ICP had low-grade systemic coagulation and fibrinolytic activation as evidenced by elevated D-dimer, and also D-dimer is associated with lower APGAR scores in both ICP and all pregnancies. Increased D-dimer levels suggest that hematological parameters could be potentially used as indicators of risk factor for assessing low APGAR score in ICP. © 2010 Informa UK, Ltd.

Pamuk B.O.,Bozyaka Training and Research Hospital | Sari I.,Bozyaka Training and Research Hospital | Sari I.,Dokuz Eylul University | Selcuk S.,Bozyaka Training and Research Hospital | And 2 more authors.
Rheumatology International | Year: 2013

The aim of this was to evaluate some of the vascular biomarkers and cytokines related with atherosclerosis in regularly treated and attack-free familial Mediterranean fever (FMF) patients. Forty (21 males [M] and 19 females [F], 31 [15-58] years) FMF patients and eighteen healthy controls (11 M and 7 F, 35.5 [19-46] years) with no known cardiovascular (CV) risk factors were included. All patients were receiving regular colchicine treatment, and examinations were performed during attack-free periods. Serum samples were used for the determination of high-sensitive C-reactive protein (hs-CRP), tissue factor (TF), tissue plasminogen activator (t-PA), osteoprotegerin (OPG), interleukin-6 (IL-6), IL-17, and IL-23. Plasma samples were used for the determination of asymmetric dimethylarginine (ADMA) and thrombomodulin (TM). Age, sex distribution, waist circumference, body mass index, smoking status, and serum lipids were similar between the patients and controls (P > 0.05). The concentrations of (hs-CRP) and IL-17 were significantly higher in FMF patients compared with controls (P < 0.05). On the other hand, IL-6 and IL-23 levels were not different between the groups (P > 0.05). ADMA, OPG, and TM concentrations were significantly lower in the patients' group compared to those of controls (P < 0.05). However, vWF, TF, and t-PA levels were similar between the groups (P > 0.05). FMF patients receiving regular colchicine therapy during inactive disease state had significantly lower levels of vascular injury parameters. © 2013 Springer-Verlag Berlin Heidelberg.

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