Chestnut Hill, MA, United States
Chestnut Hill, MA, United States

Boston College is a private Jesuit Catholic research university located in the village of Chestnut Hill, Massachusetts, USA, 6 miles west of downtown Boston. It has 9,100 full-time undergraduates and almost 5,000 graduate students. The university's name reflects its early history as a liberal arts college and preparatory school in Boston's South End. It is a member of the 568 Group and the Association of Jesuit Colleges and Universities. Its main campus is a historic district and features some of the earliest examples of collegiate gothic architecture in North America.Boston College's undergraduate program is currently ranked 31st in the National Universities ranking by U.S. News & World Report. Boston College is categorized as a research university with high research activity by the Carnegie Foundation for the Advancement of Teaching. Students at the university earned 21 Fulbright Awards in 2012, ranking the school eighth among American research institutions. At $2.131 billion, Boston College has the 40th largest university endowment in North America, and the largest endowment of all Jesuit colleges and universities.Boston College offers bachelor's degrees, master's degrees, and doctoral degrees through its nine schools and colleges: College of Arts & science, Boston College Graduate School of Arts & science, Carroll School of Management, Lynch School of Education, Connell School of Nursing, Boston College Graduate School of Social Work, Boston College Law School, Boston College School of Theology and Ministry, Woods College of Advancing Studies.Boston College sports teams are called the Eagles, and their colors are maroon and gold; the school mascot is Baldwin the Eagle. The Eagles compete in NCAA Division I as members of the Atlantic Coast Conference in all sports offered by the ACC. The men's and women's ice hockey teams compete in Hockey East. Boston College's men's ice hockey team is one of the most decorated programs in the nation, having won five national championships. Wikipedia.

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Glycosyn, Inc. and Boston College | Date: 2017-01-30

The invention provides compositions and methods for utilizing synthetic human milk oligosaccharides as prebiotics.

The invention provides novel azaborine compounds, methods for their syntheses and functionalization, and various applications thereof. For example, novel azaborine-containing biarylcarboxylic acids and biarylcarboxamides are disclosed herein, which provide the opportunity to be used as therapeutic agents in different diseases. The novel azaborine-containing compounds show unique physical and biological properties when compared to their corresponding all-carbon compounds. Also, disclosed herein are substituted 1,2-dihydro-1,2-azaborine compounds and methods for making the same including methods for the preparation of various substituted azaborines including alkyl, alkenyl, aryl, nitrile, heteroaryl, and fused ring substituents in the presence of BH, BCl, BO and NH bonds from Br-substituted azaborines as well as the synthesis of new fused BN-heterocycles.

Massachusetts Institute of Technology and Boston College | Date: 2016-08-05

The present invention relates generally to olefin metathesis. In some embodiments, the present invention provides methods for Z-selective ring-closing metathesis.

Boston College | Date: 2016-12-15

The invention provides novel devices and methods that enable ultrahigh spatial and temporal resolution interfaces that allow access and intervention to local (intra- and proximate extra-neuronal) neuroelectronic and neurotransmitter molecular signatures associated with aberrant cell function and cell death leading to neurodegenerative diseases. Scalable devices based on a unique nanoscale coaxial electrode array of the invention offer neural recording and control at unprecedented levels of precisions.

Massachusetts Institute of Technology and Boston College | Date: 2017-01-05

The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.

Dumais K.M.,Boston College | Veenema A.H.,Boston College
Frontiers in Neuroendocrinology | Year: 2016

The neuropeptides vasopressin (VP) and oxytocin (OT) and their receptors in the brain are involved in the regulation of various social behaviors and have emerged as drug targets for the treatment of social dysfunction in several sex-biased neuropsychiatric disorders. Sex differences in the VP and OT systems may therefore be implicated in sex-specific regulation of healthy as well as impaired social behaviors. We begin this review by highlighting the sex differences, or lack of sex differences, in VP and OT synthesis in the brain. We then discuss the evidence showing the presence or absence of sex differences in VP and OT receptors in rodents and humans, as well as showing new data of sexually dimorphic V1a receptor binding in the rat brain. Importantly, we find that there is lack of comprehensive analysis of sex differences in these systems in common laboratory species, and we find that, when sex differences are present, they are highly brain region- and species-specific. Interestingly, VP system parameters (VP and V1aR) are typically higher in males, while sex differences in the OT system are not always in the same direction, often showing higher OT expression in females, but higher OT receptor expression in males. Furthermore, VP and OT receptor systems show distinct and largely non-overlapping expression in the rodent brain, which may cause these receptors to have either complementary or opposing functional roles in the sex-specific regulation of social behavior. Though still in need of further research, we close by discussing how manipulations of the VP and OT systems have given important insights into the involvement of these neuropeptide systems in the sex-specific regulation of social behavior in rodents and humans. © 2015 Elsevier Inc.

Heyman G.M.,Boston College
Annual Review of Clinical Psychology | Year: 2013

According to the idea that addiction is a chronic relapsing disease, remission is at most a temporary state. Either addicts never stop using drugs, or if they do stop, remission is short lived. However, research on remission reveals a more complex picture. In national epidemiological surveys that recruited representative drug users, remission rates varied widely and were markedly different for legal and illegal drugs and for different racial/ethnic groups. For instance, the half-life for cocaine dependence was four years, but for alcohol dependence it was 16 years, and although most dependent cocaine users remitted before age 30, about 5% remained heavy cocaine users well into their forties. Although varied, the remission results were orderly. An exponential growth curve closely approximated the cumulative frequency of remitting for different drugs and different ethnic/racial groups. Thus, each year a constant proportion of those still addicted remitted, independent of the number of years since the onset of dependence. Copyright © 2013 by Annual Reviews.

Tan K.L.,Boston College
ACS Catalysis | Year: 2011

The use of reversibly formed covalent bonds to induce intramolecular reactions is a powerful way of controlling regio- and stereoselectivity, as well as accelerating reactions. Although this mode of activation was demonstrated in catalytic systems over 60 years ago, it is infrequently used in catalyst design. This review will focus on highlighting examples of reversible covalent bonding in organic catalysts as well as ligands for metal catalysis. A key aspect of this type of catalysis is that it is an entropically driven process, so it has the potential to be applied to a broad variety of reactions. Furthermore, this design element can be used in concert with more traditional forms of catalyst activation. © 2011 American Chemical Society.

Agency: NSF | Branch: Standard Grant | Program: | Phase: ITEST | Award Amount: 1.20M | Year: 2016

This project will advance efforts of the Innovative Technology Experiences for Students and Teachers (ITEST) program to better understand and promote practices that increase students motivations and capacities to pursue careers in fields of science, technology, engineering, or mathematics (STEM) by developing and testing a six-year sequence of courses and summer events designed to prepare low-income youth for the local area workforce. The project will recruit, retain, and prepare students from underrepresented populations in STEM-related fields. While in the program, students will learn: a) science concepts related to hydroponics; b) how to develop hydroponics systems that are powered by alternative energy sources; c) how to build and program robotic arms to plant and harvest produce; d) how to automate the operation and monitoring of hydroponic systems; and e) how to build and program telepresence robots while earning college credits. Midway through the program, beginning in grade 10, participating students will also benefit from a Web-based mentoring program that will facilitate interactions with STEM professionals, program alumni, and each other. The project is collaborative effort involving a school district, a community college, a university, and a mentoring organization.

Outcomes of the multi-year program of activities, courses, and mentoring strategies will be studied through a mixed-methods research approach based on a combination of survey data and participant interviews. The theoretical framework for the project is grounded in social cognitive career theory, career construction theory, and the relational theory of working. The work will be guided by four research questions: 1. To what extent does the seeding-the-future intervention foster progress in students intentions to pursue further STEM educational options and to consider STEM careers? 2. To what extent does the intervention enhance students career adaptability, as defined by academic resilience? 3. What role does relational support, as exemplified by the virtual mentoring program, support from family members, teachers, and other important people in the students lives, play in self-efficacy development, interest formation, resilience, and intentionality to pursue STEM courses and fields? And, 4. How do youth understandings of complex scientific and technological systems change over time, and what aspects of the program support youth system thinking? Constructs being measured include social support, academic support, academic resilience, mathematics and science outcome expectancy, mathematics and science intent, mathematics and science self-efficacy, and science interest.

Agency: NSF | Branch: Continuing grant | Program: | Phase: CONDENSED MATTER PHYSICS | Award Amount: 135.55K | Year: 2017

Nontechnical Abstract:
Materials can often be categorized based on how electrons within them behave. For example, in metals, electrons are free to move around and conduct electricity, while in insulators, they cannot. Topological materials are a new family of materials that cannot be classified in such a simple manner. For instance, a prototypical topological material called a topological insulator (TI) is an insulator in the bulk, but exhibits metallic behavior on the surface. In other words, only the surface of a TI is allowed to conduct electricity. Moreover, electrons on the surface of a TI can have zero mass and behave like relativistic particles. A theoretical framework for several novel types of topological materials has emerged in recent years, each one hosting new exotic properties, but experiments have struggled to fully catch up with these predictions. This project combines two advanced atomic-scale techniques to create and characterize new topological materials: (1) molecular beam epitaxy to create the materials a single atomic layer at a time, and (2) scanning tunneling microscopy to visualize their atomic and electronic structure. The project aims to provide a fundamental advancement in the understanding of topological materials, as well as to craft new materials for their eventual use in technology, such as in spintronics and quantum computing. The education goals of this project utilize the principal investigators expertise in materials growth and microscopy imaging, and are targeted to impact a wide range of students, including middle school, high school, undergraduate and graduate students. The specific efforts include establishing outreach events in local K-12 schools, participating in Research Science Institute summer program, organizing science talks at the university level, and developing courses focused on state-of-the-art synthesis and microscopy techniques.

Technical Abstract:
The past few decades have seen the emergence of several classes of materials with extraordinary physical properties, such as high-temperature superconductors, colossal magnetoresistance materials and 2D systems such as graphene. Topological materials - systems hosting novel electronic states whose existence and properties are specified by a topological invariant - are the most recent addition to the list. Prototypical topological materials are topological insulators, systems characterized by an odd Z2 topological invariant calculated from the electronic band structure. Even though topological insulators are bulk insulators, the topology of the band structure dictates the existence of gapless metallic electronic states at their boundary, occupied by massless Dirac fermions that are protected by symmetry. Recently, a theoretical framework for several new classes of topological systems has emerged, including topological crystalline insulators, topological superconductors and Weyl semimetals. However, experiments have struggled to fully catch up with these predictions, due to both synthesis and characterization bottlenecks. This project uses a rare combination of molecular beam epitaxy and spectroscopic-imaging scanning tunneling microscopy to explore new pathways for discovering and manipulating topological phases. Specifically, the project aims to create new topological phases in thin films of (Pb,Sn)Te family of semiconductors, by exploring different film thicknesses, substrates, doping and strain. Nanoscale spectroscopic characterization down to ~400 mK base temperature in variable magnetic field allows the explorations of topological phases with superior spatial and energy resolution. The education goals of this project are targeted to impact a wide range of students via establishing outreach events in local middle school and high schools, participating in Research Science Institute summer program, organizing science talks for students at the university level, and developing courses focused on state-of-the-art synthesis and microscopy techniques.

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