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Hamdi N.,Borj Cedria Higher Institute of science and Technology of Environment | Bouabdallah F.,Borj Cedria Higher Institute of science and Technology of Environment | Romerosa A.,University of Almeria | Benhassen R.,Tunis el Manar University
Comptes Rendus Chimie | Year: 2010

A new family of coumarin derivatives (4a-i) containing a chalcone moiety was synthesized by condensation of 3-acetyl-4-difluoro boryloxycoumarin (2) with aryl and heteroaryl aldehydes with piperidine in chloroform. Resulting compounds were characterized by IR, 13C, 1H NMR and UV visible spectroscopy. Compound 3-((2E)-3-(3,4,5-Trimethoxy-phenyl)prop-2-enoyl)- 2(H)-chromen-2-one (4g) was characterized by single crystal X-ray diffraction. The antioxidant and antibacterial activities of the obtained compounds 4a-i was evaluated. The biological activity found for these compounds is discussed against their structural features, physical and chemical properties. © 2010 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved. Source


Medyouni R.,Borj Cedria Higher Institute of science and Technology of Environment | Hamdi N.,Borj Cedria Higher Institute of science and Technology of Environment | Hamdi N.,Qassim University | Ben Said R.,Qassim University | And 2 more authors.
Journal of Chemistry | Year: 2013

2-Amino-3-ethoxycarbonyl-4-(aryl)-4H-pyrano-[3,2-c]-chromene-5-ones 5 is synthesized by the two-component reaction of 4-hydroxycouamrin with ethyl-2-cyano-3-(aryl) acrylate 3. The structures of the obtained compounds are confirmed by analytical IR, 1H, and 13C-NMR spectra to elucidate the different positions of protons and carbons and as well as theoretic studies (DFT/B3LYP). All the newly synthesized compounds are screened for their antibacterial. Furthermore, these compounds showed antioxidant activities of different extents with respect to individual compounds as well as to the antioxidant methods. The compounds 5a-e were found to be the most active antioxidant in the series then Trolox, which makes the investigated complexes a promising new class of antibacterial activity compounds. © 2013 R. Medyouni et al. Source

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