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Trepant A.-L.,Erasme Hospital | Sibille C.,Bordet Institute | Frunza A.-M.,Erasme Hospital | Simon P.,Erasme Hospital | Noel J.-C.,Erasme Hospital
Pathology Research and Practice | Year: 2014

Breast myofibroblastomas are rare benign mesenchymal tumors belonging to the group of stromal breast tumors composed of spindle-shaped cells and characterized by a broad morphologic spectrum. Among the different morphologic variants described, breast MFBs can show smooth muscle cell differentiation in very rare cases.In terms of the genetic abnormalities found in this type of tumor, a deletion of chromosome 13q14 was recently confirmed by FISH in some cases of mammary MFB.In this paper, we report an unusual case of MFB with smooth muscle differentiation showing a deletion of chromosome 13q14. © 2014 Elsevier GmbH. Source

Bruyneel M.,Saint Pierre University Hospital | Sanida C.,Saint Pierre University Hospital | Art G.,Saint Pierre University Hospital | Libert W.,Saint Pierre University Hospital | And 4 more authors.
Journal of Sleep Research | Year: 2011

To date, the clinical use of unattended home-based polysomnography (PSG) is not recommended. To assess whether sleep efficiency is better at home, we have performed a prospective, crossover, single-blind study comparing unattended home- versus attended in-hospital PSG in a population referred for high clinical suspicion of obstructive sleep apnoea syndrome (OSA). Within 2weeks, all the patients underwent both PSG performed by the same sleep technician, which were analysed by another blinded technician. Payments for each procedure were also calculated. Sixty-six patients (mean age: 49±13years; mean body mass index: 30±7; mean Epworth Sleepiness Scale: 10±5) were included. The quality of recordings was poor in 1.5% of the attended PSG versus 4.7% for unattended PSG (P=0.36). Sleep efficiency at home was better (82% versus 75%, P<0.001), and sleep duration longer (412min versus 365min, P<0.001). Sleep latency was also shorter at home (28min versus 45min, P=0.004), and patients spent more time in rapid eye movement sleep (19% versus 16%, P=0.006). Apnoea-hypopnoea index (23 versus 26, P=0.08) was similar at home and in the sleep lab. Sixty-seven per cent of patients preferred home-based PSG. PSG payment was also lower at home (268 Euros versus 1057 Euros). We conclude that home-based PSG is associated with a better sleep efficiency. It also appears as feasible and reliable in patients with high preclinical suspicion for OSA. It is also more comfortable for the patients whose sleep efficiency is better and allows cost saving related to the absence of hospitalization. © 2010 European Sleep Research Society. Source

Bruyneel M.,Saint Pierre University Hospital | Libert W.,Saint Pierre University Hospital | Ameye L.,Bordet Institute | Ninane V.,Saint Pierre University Hospital
Sleep Medicine | Year: 2015

Background: Unattended home-based polysomnography (H-PSG) is a reliable tool for the diagnosis of obstructive sleep apnoea (OSA). The quality of the recording can be influenced by several factors including the set-up location - at home versus in the sleep laboratory. Previous studies have suggested that the failure rate is higher when H-PSG is fitted in hospital. The aim of this study was to determine the influence of hook-up location on H-PSG recording quality. Feasibility and repeatability of H-PSG were also assessed. Methods: Consecutive patients suspected of OSA were selected. Each patient underwent two H-PSGs within two weeks, one fitted at home and one fitted in the sleep laboratory. The order of H-PSG was randomly assigned. Results: Among the 102 included patients, 95 completed the study. Ninety-three per cent of the 190 H-PSGs were satisfactory. The failure rate of H-PSG was similar for both the home set-up and the sleep laboratory set-up (p = 0.33). Seventy-nine per cent of patients opted to be fitted at home. OSA was diagnosed in 59%. The apnoea-hypopnoea index was similar for home and sleep laboratory set-up, resulting in a very good reproducibility (intraclass correlation coefficient of 0.85). No differences in total sleep time and sleep architecture were observed in both set-up protocols. Except for sleep duration, which was longer in the first H-PSG test, we did not observe any first-night effect during the first H-PSG. Conclusion: The present study demonstrates that hospital hook-up is as effective as home hook-up for home-unattended polysomnography, and that feasibility and repeatability of H-PSG are very good. © 2015 Elsevier B.V. Source

Bruyneel M.,Saint Pierre University Hospital | Jacob V.,Saint Pierre University Hospital | Sanida C.,Saint Pierre University Hospital | Ameye L.,Bordet Institute | And 2 more authors.
European Journal of Internal Medicine | Year: 2011

Background: Several phenotypes are described in COPD. Objectives: To assess if COPD patients with Hoover's sign (HS) belong to a particular phenotype. Methods: All consecutive COPD patients with varying degree of airflow obstruction that came for lung function testing in one university hospital were prospectively assessed, using clinical and magnetometer detection of HS, body mass index (BMI), St. George's Respiratory Questionnaire for health-related quality of life, six-minute-walk test (6MWT) with inspiratory capacity (IC) measurements and expiratory flow limitation (EFL) detection. Previous exacerbations were also reported. Results: 82 patients were studied. Magnetometers confirmed HS in 56 of them, of which 79% (44/56) were detected by clinical assessment. HS (+) patients were older (64 ± 10 vs 59 ± 10 years, p = 0.03), had a higher BMI (26 ± 5 vs 23 ± 4, p = 0.04), a lower FEV1 (53% ± 18% vs 63% ± 18% pred, p = 0.02) and a higher IC decrease at the end of 6MWT, (- 19 ± 2 vs - 7 ± 4% pred, p = 0.003). A larger proportion of HS (+) patients also reported severe exacerbations during the past 2 years (39% vs 12% p = 0.01). There was no statistical evidence that HS was related to hyperinflation and/or EFL. Conclusion: The very simple clinical HS allows identifying a particular population of COPD patients of older age and higher BMI with a more severe airflow obstruction, increased dynamic hyperinflation during exercise and higher exacerbation frequency. These characteristics were not linked to hyperinflation or EFL. © 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. Source

Janik M.E.,Jagiellonian University | Litynska A.,Jagiellonian University | Vereecken P.,C.H.U. Brugmann | Vereecken P.,Jules Bordet Institute | Vereecken P.,Bordet Institute
Biochimica et Biophysica Acta - General Subjects | Year: 2010

Background: Cell migration is an essential process in organ homeostasis, in inflammation, and also in metastasis, the main cause of death from cancer. The extracellular matrix (ECM) serves as the molecular scaffold for cell adhesion and migration; in the first phase of migration, adhesion of cells to the ECM is critical. Engagement of integrin receptors with ECM ligands gives rise to the formation of complex multiprotein structures which link the ECM to the cytoplasmic actin skeleton. Both ECM proteins and the adhesion receptors are glycoproteins, and it is well accepted that N-glycans modulate their conformation and activity, thereby affecting cell-ECM interactions. Likely targets for glycosylation are the integrins, whose ability to form functional dimers depends upon the presence of N-linked oligosaccharides. Cell migratory behavior may depend on the level of expression of adhesion proteins, and their N-glycosylation that affect receptor-ligand binding. Scope of review: The mechanism underlying the effect of integrin glycosylation on migration is still unknown, but results gained from integrins with artificial or mutated N-glycosylation sites provide evidence that integrin function can be regulated by changes in glycosylation. General significance: A better understanding of the molecular mechanism of cell migration processes could lead to novel diagnostic and therapeutic approaches and applications. For this, the proteins and oligosaccharides involved in these events need to be characterized. © 2010 Elsevier B.V. Source

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