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Fukuoka-shi, Japan

Patent
Bonac Corporation | Date: 2014-06-12

Provided is a novel nucleic acid molecule that is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes, in sequence from the 5 side to the 3 side: a 5 side region (Xc); an inner region (Z); and a 3 side region (Yc). The inner region (Z) is composed of an inner 5 side region (X) and an inner 3 side region (Y) that are linked to each other. The 5 side region (Xc) is complementary to the inner 5 side region (X). The 3 side region (Yc) is complementary to the inner 3 side region (Y). At least one of the inner region (Z), the 5 side region (Xc), and the 3 side region (Yc) includes the expression inhibitory sequence.


The invention provides a glucoside compound, which is capable of providing a phosphoramidite, which can be produced at low cost and can produce a nucleic acid in high yield and with high purity. The glycoside compound has the formula wherein B, R


Patent
Bonac Corporation | Date: 2013-03-04

The invention provides a microRNA inhibitor that has two or more sequences complementary to the sequence of microRNA to be the target of inhibition, which two or more complementary sequences are linked via one or more linker residues.


Patent
Bonac Corporation | Date: 2012-05-07

The present invention provides a process for preparing an isotope-containing phosphate compound easily. The process for preparing an isotope-containing phosphate compound according to the present invention includes the step of oxidizing a trivalent phosphorus compound with an oxidizing agent containing an isotope to synthesize a pentavalent phosphate compound to which the isotope has been introduced. The present invention preferably is applied to the synthesis of nucleic acids such as DNA and RNA, for example. The isotope preferably is a stable isotope. The oxidizing agent preferably is H


Patent
Bonac Corporation | Date: 2015-10-29

Provided is a novel nucleic acid molecule that is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes, in sequence from the 5 side to the 3 side: a 5 side region (Xc); an inner region (Z); and a 3 side region (Yc). The inner region (Z) is composed of an inner 5 side region (X) and an inner 3 side region (Y) that are linked to each other. The 5 side region (Xc) is complementary to the inner 5 side region (X). The 3 side region (Yc) is complementary to the inner 3 side region (Y). At least one of the inner region (Z), the 5 side region (Xc), and the 3 side region (Yc) includes the expression inhibitory sequence.

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