Bogomoletz Institute of Physiology NAS of Ukraine

Kiev, Ukraine

Bogomoletz Institute of Physiology NAS of Ukraine

Kiev, Ukraine

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PubMed | Melitopol State Pedagogical University, Medical University of Graz, University of Genoa, Bogomoletz Institute of Physiology NAS of Ukraine and University of Geneva
Type: | Journal: Vascular pharmacology | Year: 2017

Lysophosphatidylinositol (LPI) and lysophosphatidylcholine (LPC) are lipid signaling molecules that induce endothelium-dependent vasodilation. In addition, LPC suppresses acetylcholine (Ach)-induced responses. We aimed to determine the influence of LPC and LPI on hyperpolarizing responses in vitro and in situ endothelial cells (EC) and identify the underlying mechanisms. Using patch-clamp method, we show that LPI and LPC inhibit EC hyperpolarization to histamine and suppress Na

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