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Tryliskyy Y.,Bogomolets National Medical University
Travel Medicine and Infectious Disease | Year: 2011

This study was undertaken to assess the duration of altitude acclimatization retention in individuals after initial exposure to a maximum altitude of 5360 m during a mountaineering expedition. Spectral heart rate variability analysis accompanied by an assessment of acute mountain sickness using the Lake Louise Scoring System was performed during two sequential mountaineering expeditions to altitudes of 5360 m and 5642 m, with a period of 30 days between each expedition. Subjects displayed varying degrees of alterations in heart rate variability during the initial expedition, which indicated differing degrees of dysadaptation and stress development. Their Lake Louise Scores accounted for the presence of acute mountain sickness throughout the trip. During the subsequent expedition, the subjects' heart rate variability measures were within the normal range, and there were no signs of acute mountain sickness. All three subjects who underwent step-by-step exposure to altitudes of 5360 m displayed differing degrees of alterations in heart rate variability in conjunction with differing degrees of acute mountain sickness. All subjects also developed acclimatization to hypoxic conditions at this altitude, which was preserved for 30 days, and was sufficient to prevent them from showing any significant alterations in heart rate variability when re-exposed to the same altitude. © 2011 Elsevier Ltd. All rights reserved.

Kobyliak N.,Bogomolets National Medical University | Abenavoli L.,University of Catanzaro
Reviews on Recent Clinical Trials | Year: 2014

Liver biopsy, since 1883, when were first performed, became the gold standard to confirm the earlier stages of fibrosis and grading of non-alcoholic fatty liver disease (NAFLD) and for distinguishing simple steatosis from nonalcoholic steatohepatitis (NASH). General limitations of liver biopsy are sampling error and interand intraobserver variability. Also procedure is invasive and that’s why associated with some potential adverse effects and complications which may be minor (pain or vagal reactions, transient hypotension) or major such as visceral perforation, bile peritonitis or significant bleeding. Presence of steatosis, hepatocellular injury in the form of ballooning, lobular inflammation and perisinusoidal fibrosis, usually with a zone 3 distribution are considered to be most important histological features of adult NAFLD which may differ from bariatric surgery or pediatric patients. In addition, grading and staging and current semiquantitative systems for NAFLD assessment are discussed. © 2014 Bentham Science Publishers.

Shatursky O.Ya.,Palladin Institute of Biochemistry | Romanenko O.V.,Bogomolets National Medical University | Himmelreich N.H.,Palladin Institute of Biochemistry
Journal of Membrane Biology | Year: 2014

The action of antifungal drug, amphotericin B (AmB), on solvent-containing planar lipid bilayers made of sterols (cholesterol, ergosterol) and synthetic C14-C18 tail phospholipids (PCs) or egg PC has been investigated in a voltage-clamp mode. Within the range of PCs tested, a similar increase was achieved in the lifetime of one-sided AmB channels in cholesterol- and ergosterol-containing membranes with the C16 tail PC, DPhPC at sterol/DPhPC molar ratio ≤1. The AmB channel lifetimes decreased only at sterol/DPhPC molar ratio >1 that occurred with sterol/PC molar ratio of target cell membranes at a pathological state. These data obtained on bilayer membranes two times thicker than one-sided AmB channel length are consistent with the accepted AmB pore-forming mechanism, which is associated with membrane thinning around AmB-sterol complex in the lipid rafts. Our results show that AmB can create cytotoxic (long open) channels in cholesterol membrane with C14-C16 tail PCs and nontoxic (short open) channels with C17-C18 tail PCs as the lifetime of one-sided AmB channel depends on ∼2-5 Å difference in the thickness of sterol-containing C16 and C18 tail PC membranes. The reduction in toxic AmB channels efficacy can be required at the drug administration because C16 tails in native membrane PCs occur almost as often as C18 tails. The comparative analysis of AmB channel blocking by tetraethylammonium chloride, tetramethylammonium chloride and thiazole derivative of vitamin B1, 3-decyloxycarbonylmethyl-4-methyl-5-(2-hydroxyethyl) thiazole chloride (DMHT), has proved that DMHT is a comparable substitute for both tetraalkylammonia that exhibits a much higher affinity. © 2014 Springer Science+Business Media.

Chalyi A.V.,Bogomolets National Medical University
Springer Proceedings in Physics | Year: 2015

Problem of finding the pair correlation function G2 and correlation length ξ of order parameter fluctuations in liquids in restricted geometry is discussed. Two types of dimensional crossover (DC) are studied. The 1st type (DC-1) corresponds to transition from 3D bulk to 3D bounded liquids. In this case the dependence of physical properties on thermodynamic variables (temperature, density, pressure, etc.) in bulk liquids with linear sizes L ≫ ξ may convert into dependence of these properties on linear sizes in bounded liquids with L < ξ. The 2nd type (DC-2) corresponds to the case when a further decreasing of linear sizes in confined liquids may be treated under certain conditions as the change of spatial dimensionality D (for example, 3D ⇔ 2D crossover in slit-like pores or 3D ⇔ 1D crossover in cylindrical pores). Smooth transition of effective critical exponents (say, from ν = 0.625 for D = 3 to ν = 1 for D = 2) as well as theoretical results versus experimental data are examined for liquids in reduced geometry. © Springer International Publishing Switzerland 2015.

Lemche A.V.,Charite - Medical University of Berlin | Chaban O.S.,Bogomolets National Medical University | Lemche E.,Kings College London
Psychiatry Research | Year: 2014

Alexithymia is a clinical trait consisting of diminished introspective and interoceptive capacities that has been shown to implicate elevated autonomic outflow and to bias for hypertension. To estimate relative risk associated with alexithymia in the metabolic syndrome (MetS), we conducted a cross-sectional analysis of patients with manifest type 2 diabetes mellitus (T2DM) or familial diabetes risk (N=101; 67 females; age 45.6±13.96) in a nationwide sampled treatment cohort for MetS in the Ukrainian governmental health care system. Laboratory data of single components of the MetS according to International Diabetes Federation Consensus were dependent measures in multivariable regression models with self-reported alexithymia severity (TAS-20) and socio-demographic data. TAS-20 as the sole surviving psychometric predictor for T2DM in the simplest regression equation provided the best model fit: OR 1.073, Z=19.04, (95%CIs 1.065-1.081). For microalbuminuria, the best fitting model was OR 1.030, Z=3.49 (95%CIs 1.013-1.048). TAS-20 predicted also triglyceride level at Wald-χ2=1299.27, Z=36.05 (95%CIs 0.052-0.058) and blood pressure maximum at Wald-χ2=2309.05, Z=48.05 (95%CIs 2.402-2.606). Our results show that alexithymia severity contributes to MetS by covarying with several of its single components, and that it may be a substantial concurrent indicator of T2DM and cardiovascular risks in MetS. © 2013 Elsevier Ireland Ltd.

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