Ridgefield, CT, United States
Ridgefield, CT, United States

C.H. Boehringer Sohn AG & Ko. KG is the parent company of Boehringer Ingelheim, which was founded in 1885 by Albert Boehringer in Ingelheim am Rhein, Germany. The Boehringer Ingelheim group is one of the world's 20 leading pharmaceutical companies. Still headquartered in Ingelheim, it operates globally with 140 affiliates and more than 47,000 employees. The company's key assets of interest are: respiratory diseases, cardiovascular diseases, Parkinson's disease, HIV, thromboembolic diseases, cerebrovascular diseases, oncology, diabetes and hepatitis. Since it was founded in 1885, the family-owned company has been committed to researching, developing, manufacturing and marketing novel products of high therapeutic value for human and veterinary medicine. Boehringer Ingelheim is a full member of the European Federation of Pharmaceutical Industries and Associations EFPIA. The corporate logo of Boehringer Ingelheim depicts a stylized rendition of the central section of the imperial palace of Charlemagne.In October 2012 Boehringer Ingelheim settled a "qui tam" case with the U.S. government for $95 million alleging "off-label" marketing of the drugs Aggrenox, Atrovent, Combivent, and Micardis for uses that weren't approved by the US Food and Drug Administration and were not covered by federal health care programs.In August 2012, Pradaxa claims filed in the federal court were consolidated in a multi-district litigation in the Southern District of Illinois before Chief Judge David R. Herndon. On May 28, 2014,a $650 million settlement was announced on behalf of approximately 3,900 claimants who were injured by the drug Pradaxa made by Boehringer Ingelheim Pharmaceuticals, Inc. The drug is alleged to cause severe bleeding events and/or hemorrhaging to those who were taking the drug. Wikipedia.


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— Rising number of chronic kidney diseases (CKD) and dialysis patient pools are the major drivers for the market. Moreover, increasing cases of cancer, HIV‘s and ESRD (End Stage Renal Diseases) are some of the factors enhancing the market growth. However, growing competition from substitute drugs and rising threats from thrombosis and PRCA are the factors inhibiting the market size. By Application, anemia segment leads the Erythropoietin Drugs market during the forecast period. On the other hand, retail pharmacies in end user segment dominated the global market with a huge market share. In terms of geography, Europe commanded the maximum market share and will continue to dominate the market over the forecast period. Some of the key players in the market include Johnson and Johnson, Hospira, Inc., F. Hoffmann-La Roche AG, Amgen Inc, Kyowa Hakko Kirin Co., Ltd, 3SBio Inc., Boehringer Ingelheim Pharmaceuticals, Inc., Intas Pharmaceuticals, Dr. Reddy's Laboratories, Teva Pharmaceutical Industries, JCR Pharmaceuticals, LG Life Science, Novartis AG, Shenyang Sunshine Pharmaceutical, Sihuan Pharmaceutical, Uni-Bio Science, Wanbang Biochemical Pharmaceuticals, Pfizer Inc., Chugai Pharmaceutical and Dragon Pharma. Regions Covered: • North America o US o Canada o Mexico • Europe o Germany o France o Italy o UK o Spain o Rest of Europe • Asia Pacific o Japan o China o India o Australia o New Zealand o Rest of Asia Pacific • Rest of the World o Middle East o Brazil o Argentina o South Africa o Egypt What our report offers: - Market share assessments for the regional and country level segments - Market share analysis of the top industry players - Strategic recommendations for the new entrants - Market forecasts for a minimum of 6 years of all the mentioned segments, sub segments and the regional markets - Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations) - Strategic recommendations in key business segments based on the market estimations - Competitive landscaping mapping the key common trends - Company profiling with detailed strategies, financials, and recent developments About Stratistics MRC We offer wide spectrum of research and consulting services with in-depth knowledge of different industries. We are known for customized research services, consulting services and Full Time Equivalent (FTE) services in the research world. We explore the market trends and draw our insights with valid assessments and analytical views. We use advanced techniques and tools among the quantitative and qualitative methodologies to identify the market trends. Our research reports and publications are routed to help our clients to design their business models and enhance their business growth in the competitive market scenario. We have a strong team with hand-picked consultants including project managers, implementers, industry experts, researchers, research evaluators and analysts with years of experience in delivering the complex projects. For more information, please visit http://www.strategymrc.com


Additionally, a pooled analysis from the TOMORROW™, and INPULSIS® trials assessed the incidence rates for major adverse cardiovascular events (MACE) among patients treated with Ofev and placebo. Most patients included in this analysis (90%) had a high cardiovascular (CV) risk at baseline, including a history of fatty-plaque build-up in the arteries (called atherosclerosis) and/or at least one CV risk factor such as high blood pressure, diabetes or elevated blood cholesterol levels. Overall, the incidence of MACE was similar between the treatment groups both in patients with a high CV risk (3.5%, Ofev vs. 3.3%, placebo) and low CV risk (4.5%, Ofev vs. 5.3%, placebo) at baseline. "IPF is a progressive disease that requires ongoing treatment. So, it is important to assess the long-term efficacy and safety of IPF treatments like Ofev to ensure we are maintaining lung function and reducing disease progression while not exacerbating co-existing conditions," said Imre Noth, M.D., professor of medicine and director of the Interstitial Lung Disease Program at the University of Chicago. "These new data help to further strengthen the science supporting the efficacy and safety of Ofev for up to 96 weeks of treatment, and offer physicians additional evidence to support their treatment decisions." New Insights about IPF Patients  A separate analysis presented at ATS examined data from the IPF-PRO patient registry at 18 pulmonary care sites to identify the clinical characteristics of IPF patients who have advanced lung function impairment. Most clinical studies have included IPF patients with mild to moderate lung function impairment, and investigators wanted to understand how patients with more advanced disease differed. Patients with advanced IPF at baseline had greater physical impairment versus patients with mild to moderate disease, including lower six-minute walk distance (320 feet vs. 397 feet). The more advanced IPF patients also had an increased prevalence of hypoxemia (low blood oxygen), both at rest (36.6% vs. 7.4%) and while active (62.4% vs. 20.2%), requiring more supplemental oxygen, as well as a history of pulmonary arterial hypertension, or high blood pressure in the lungs (14.0% vs. 6.4%). In addition, health-related quality of life (HRQL) scores were significantly worse in those with advanced lung function impairment. "At Boehringer Ingelheim, we are committed to IPF and broader ILD research and advancements to better understand these devastating diseases," said Thomas Leonard, Ph.D., executive director, Clinical Development and Medical Affairs, Specialty Care, Boehringer Ingelheim Pharmaceuticals, Inc. "Through ongoing research, we are able to provide the IPF community with the information they need to make informed treatment decisions." Ongoing research is being conducted for the treatment of Ofev in patients with IPF and other interstitial lung diseases. Nintedanib is also being investigated for the treatment of systemic sclerosis with associated interstitial lung disease (SSc-ILD), as well as progressive fibrosing interstitial lung disease (PF-ILD). Additionally, the first following the approval of Ofev for the treatment of IPF is completed and will add evidence to the safety and tolerability of nintedanib in combination with pirfenidone. Results from the 12-week, randomized INJOURNEY trial will be presented at an upcoming international medical congress. The corresponding abstracts can be found within the online program, here: https://cms.psav.com/ats2017/confcal About idiopathic pulmonary fibrosis (IPF)  IPF is a rare and serious lung disease that causes permanent scarring of the lungs. It affects as many as 132,000 Americans, typically men over the age of 65. Early diagnosis and proper care are critical to helping people treat their condition. About the INPULSIS® trials INPULSIS®-1 and -2 are two global Phase III trials which evaluated the efficacy and safety of nintedanib in the treatment of idiopathic pulmonary fibrosis (IPF). The INPULSIS® trials were identical in design, e.g., with matching dosing, inclusion criteria and endpoints. INPULSIS® recruited a range of patient types – similar to those seen in clinical practice including patients with early disease (FVC > 90% pred), no honeycombing on HRCT and/or concomitant emphysema. Patients who completed the 52-week treatment period and a 4-week follow-up period in the INPULSIS® trials were offered open-label treatment with Ofev® as part of an extension trial to assess the long-term safety and tolerability of Ofev. The INPULSIS®-ON (Clinicaltrial.gov trial identifier: NCT01619085) trial included 734 patients and is currently ongoing. About Ofev® (nintedanib)  The U.S. Food and Drug Administration (FDA) approved Ofev for the treatment of idiopathic pulmonary fibrosis (IPF) on October 15, 2014. Ofev is one of the first FDA-approved drug treatments for IPF and the only kinase inhibitor approved to treat this disease. The approval was based on findings from a robust clinical trial program involving more than 1,200 patients with IPF worldwide, and included the Phase II TOMORROW™ trial and the Phase III INPULSIS® trials (INPULSIS®-1 and INPULSIS®-2. All these studies were randomized, double-blind, placebo-controlled trials comparing Ofev 150 mg twice daily to placebo for 52 weeks. Both INPULSIS® trials were identically designed while the TOMORROW™ study design was similar. What is Ofev? Ofev is a prescription medicine used to treat people with a lung disease called idiopathic pulmonary fibrosis (IPF). It is not known if Ofev is safe and effective in children. What is the most important information I should know about Ofev (nintedanib)? Ofev can cause harm, birth defects or death to an unborn baby.  Women should not become pregnant while taking Ofev. Women who are able to become pregnant should have a pregnancy test before starting treatment and should use birth control during and for at least 3 months after your last dose. If you become pregnant while taking Ofev, tell your doctor right away. What should I tell my doctor before using Ofev? Before you take Ofev, tell your doctor if you have: Tell your doctor if you: Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements such as St. John's wort. What are the possible side effects of Ofev? Ofev may cause serious side effects. TELL YOUR DOCTOR RIGHT AWAY if you are experiencing any side effects, including: The most common side effects of Ofev are diarrhea, nausea, stomach pain, vomiting, liver problems, decreased appetite, headache, weight loss, and high blood pressure. These are not all the possible side effects of Ofev. For more information, ask your doctor or pharmacist. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. About Boehringer Ingelheim  Boehringer Ingelheim Pharmaceuticals, Inc., based in Ridgefield, CT, is the largest U.S. subsidiary of Boehringer Ingelheim Corporation. Boehringer Ingelheim is one of the world's top 20 pharmaceutical companies. Headquartered in Ingelheim, Germany, the company operates globally with approximately 50,000 employees. Since its founding in 1885, the company has remained family-owned and today creates value through innovation for three business areas including human pharmaceuticals, animal health and biopharmaceutical contract manufacturing. Boehringer Ingelheim is committed to improving lives and providing valuable services and support to patients and their families. Our employees create and engage in programs that strengthen our communities. Please visit our  to learn more about how we make more health for more people through our Corporate Social Responsibility initiatives. In 2016, Boehringer Ingelheim achieved net sales of about $17.6 billion (15.9 billion euros). R&D expenditure corresponds to 19.6 percent of its net sales. For more information please visit www.boehringer-ingelheim.us, or follow us on Twitter @BoehringerUS. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/ipf-patients-treated-with-ofev-nintedanib-versus-placebo-were-twice-as-likely-to-have-improved-or-stable-lung-function-300462288.html


Pilot programs demonstrate that digital learning increases physician engagement and empowers patients to self-advocate ​​​​​The Academy of Continued Healthcare Learning (ACHL), ProPatient, and ArcheMedX have launched a series of integrated online learning programs that have successfully educated and empowered both healthcare providers and patients/caregivers to share decision making in addressing the challenges of treating Idiopathic Pulmonary Fibrosis (IPF) and Non-Small Cell Lung Cancer (NSCLC). As scientific discoveries accelerate and our healthcare system becomes more complex, it is critical for clinicians and patients to communicate and collaborate to optimize patient-centric care. While the benefits of shared decision making are well established, it is far from the norm and significant efforts are need to ensure that all stakeholders are comfortable, capable, and committed. “Online learning is a cost-effective way to provide physicians with on-demand access to the latest clinical advances and a trusted channel to educate and empower patients to participate in their care,” said Lisa Keckich, Executive Director at ACHL. She added, “ACHL entered into this partnership to assess whether an integrated educational approach would facilitate shared decision making for complex diseases like IPF and lung cancer. The success of these initiatives demonstrates the power of the ArcheMedX and ProPatient platforms to educate and motivate clinicians and patients to work collaboratively and has established a model we eagerly anticipate extending to additional clinical areas.” Through these interventions clinicians are better prepared to guide their patients through a shared decision making process and patients are better informed and more empowered to participate in their care. Since launching in December 2016, more than a thousand clinicians and patients have participated in the educational program, enhancing multidisciplinary approaches to care and addressing the unique and evolving needs of patients with IPF. 80% of clinicians engaged by the program reported making changes to their shared decision-making practices since participating. Furthermore, 85% of IPF patients reported that the patient education activity helped them better understand IPF. You can learn more about this IPF program here. Since launching in June 2016, thousands of lung cancer clinicians and patients have participated in the educational program, enhancing personalized approaches to care and simplifying important challenges related to diagnosis and treatment. 90% of clinicians engaged by the program reported that they had increased the frequency in which they engage their patients with NSCLC in shared decision-making since participating. 58% of patients feel that they learned from the activity and were better able to understand their diagnosis. You can learn more about this NSCLC program here. *These interventions would not be possible without commercial support. The IPF program is supported by educational grants from Boehringer Ingelheim Pharmaceuticals, Inc. and Genentech, Inc. and the NSCLC program is supported by an educational grant from Genentech, Inc. ACHL is an-award winning provider of continuing medical education programs.  Its mission is to design, develop, and implement quality continuing education activities that have a positive influence on the way healthcare is practiced and ultimately, to improve the quality of care provided to patients. ProPatient is a patient-focused, online educational platform that utilizes interactive video and engaging simulation to provide patients with the opportunity to ask questions of a virtual clinician and role-play different scenarios to improve their skills. ArcheMedX is a healthcare informatics and e-learning technology company that is transforming online education through a data-driven approach to learning. By leveraging nearly five decades of cognitive science and years of applied research, the ArcheMedX team has developed an award-winning e-learning and analytics platform that simplifies the design, delivery, and analysis of online education and training across the healthcare industry. ArcheMedX currently partners with dozens of healthcare organizations (national medical societies, leading academic medical centers, major pharmaceutical firms, and global medical education companies) to power and analyze hundreds of more engaging and interactive learning experiences available across dozens of clinical and non-clinical areas. Learners who participate in ArcheMedX-powered education have been found to improve their knowledge and competence at a level four-to-six times greater than traditional online education. To learn more, visit www.archemedx.com.


RIDGEFIELD, Conn., May 23, 2017 /PRNewswire/ -- Boehringer Ingelheim today announced new analyses that provide further evidence that adding SPIRIVA RESPIMAT improved breathing across diverse patient populations who experience uncontrolled asthma symptoms despite the use of another daily...


Zika Virus - What You Should Know The adverse health effects of synthetic chemicals usually found in common household or agricultural products like insecticides are being revealed. A new research from the University at Buffalo adds another reason why it's best to steer clear from these types of chemicals at all cost. Insecticides are actually a type of pesticide specific to insects. They are frequently used in agriculture, industrial, public health, and household setting to ward off or totally eliminate undesirable bugs, such as roaches, mosquitoes, and termites. Other forms of pesticides include herbicides (non-beneficial plants or weeds), fungicides (molds, mildew, and rust), rodenticides (rats, mice, gophers), algaecides (algae), disinfectants and antimicrobials (bacteria and viruses). Insecticides are available in various formulations and ways of applications. Some of these include sprays, baits, and slow-release diffusion. According to EPA, the most commonly used insecticides are the organophosphates, pyrethroids, and carbamates. Based on a 2001 report by the U.S. Department of Agriculture (USDA) insecticides accounted for 12 percent of total pesticides applied to the surveyed crops. Corn and cotton, on the other hand, account for the largest shares of insecticide use in the United States. A study published in Chemical Research in Toxicology discovered alarming health consequences humans are at risk of when exposed to active chemical ingredients in insecticides. "No one was thinking that the melatonin system was affected by these compounds, but that's what our research shows," Marina Popovska-Gorevski, co-author, now a scientist with Boehringer Ingelheim Pharmaceuticals, stated. "We found that both insecticides are structurally similar to melatonin and that both showed affinity for the melatonin, MT2 receptors, that can potentially affect glucose homeostasis and insulin secretion," Popovska-Gorevski said. "That means that exposure to them could put people at higher risk for diabetes and also affect sleeping patterns," she added. Funded by a grant from the National Institute of Environmental Health Sciences, under the National Institutes of Health (NIH), the study centers on two chemicals: carbaryl (which despite being banned in many countries, is currently the third most extensively used insecticide in the United States), and carbofuran (which is considered as the most lethal carbamate insecticide prohibited from all forms of applications on food crops for human consumption since 2009). Pesticides are everywhere, but with a conscious effort, it's possible to reduce risks of being exposed to them. Go for green and chemical-free alternatives when addressing pest issues at home or garden. Opt for organic fruits and vegetables. Diet plays a big part, too, since most crops in the country are notorious for being heavily sprayed with chemical fertilizers and pesticides. © 2017 Tech Times, All rights reserved. Do not reproduce without permission.


Michel M.C.,Boehringer Ingelheim | Michel M.C.,Johannes Gutenberg University Mainz | Foster C.,Boehringer Ingelheim Pharmaceuticals | Brunner H.R.,University of Lausanne | Liu L.,Fu Wai Hospital
Pharmacological Reviews | Year: 2013

Angiotensin II type 1 receptor antagonists (ARBs) have become an important drug class in the treatment of hypertension and heart failure and the protection from diabetic nephropathy. Eight ARBs are clinically available [azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan]. Azilsartan (in some countries), candesartan, and olmesartan are orally administered as prodrugs, whereas the blocking action of some ismediated through active metabolites. On the basis of their chemical structures, ARBs use different binding pockets in the receptor, which are associated with differences in dissociation times and, in most cases, apparently insurmountable antagonism. The physicochemical differences between ARBs also manifest in different tissue penetration, including passage through the blood-brain barrier. Differences in binding mode and tissue penetration are also associated with differences in pharmacokinetic profile, particularly duration of action. Although generally highly specific for angiotensin II type 1 receptors, some ARBs, particularly telmisartan, are partial agonists at peroxisome proliferator-activated receptor-g. All of these properties are comprehensively reviewed in this article. Although there is general consensus that a continuous receptor blockade over a 24-hour period is desirable, the clinical relevance of other pharmacological differences between individual ARBs remains to be assessed. © 2013 by The American Society for Pharmacology and Experimental Therapeutics.


Methods for the diagnosis of inflammatory bowel diseases and the identification of agents useful in the treatment of such diseases based upon the agents effect on reducing Pim-2 expression.


Patent
Boehringer Ingelheim Pharmaceuticals | Date: 2012-03-29

The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The polypeptides and/or antibodies described herein can be used in methods for detection and treatment of certain autoimmune and inflammatory diseases including asthma.


Patent
Boehringer Ingelheim Pharmaceuticals | Date: 2011-12-19

A method for modulating NF-B dependent gene transcription in a cell comprised of modulating IKK and IKK protein and protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-B dependent gene transcription.


Patent
Boehringer Ingelheim Pharmaceuticals | Date: 2011-07-27

An automated data processing method for obtaining clinical data for safety, efficacy, and adverse event assessments pertaining to a therapy prescribed for the treatment of a malady, comprising the step of receiving at a location remote from a plurality of patients outcome digital information pertaining to the outcome of therapies performed on said patients, and for the efficient delivery of medications to a patient ordered pursuant to an electronic prescription from a dispensary optimized for delivery of the medication.

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