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Chuncheon, South Korea

Sha K.,University of Tennessee at Knoxville | Choi S.-H.,University of Tennessee at Knoxville | Choi S.-H.,Boditech Med Inc. | Im J.,University of Tennessee at Knoxville | And 3 more authors.
PLoS ONE | Year: 2014

Impaired ethanol metabolism can lead to various alcohol-related health problems. Key enzymes in ethanol metabolism are alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH); however, neuroendocrine pathways that regulate the activities of these enzymes are largely unexplored. Here we identified a neuroendocrine system involving Corazonin (Crz) neuropeptide and its receptor (CrzR) as important physiological regulators of ethanol metabolism in Drosophila. Crz-cell deficient (Crz-CD) flies displayed significantly delayed recovery from ethanol-induced sedation that we refer to as hangover-like phenotype. Newly generated mutant lacking Crz Receptor (CrzR01) and CrzR-knockdown flies showed even more severe hangover-like phenotype, which is causally associated with fast accumulation of acetaldehyde in the CrzR 01 mutant following ethanol exposure. Higher levels of acetaldehyde are likely due to 30% reduced ALDH activity in the mutants. Moreover, increased ADH activity was found in the CrzR01 mutant, but not in the Crz-CD flies. Quantitative RT-PCR revealed transcriptional upregulation of Adh gene in the CrzR01. Transgenic inhibition of cyclic AMP-dependent protein kinase (PKA) also results in significantly increased ADH activity and Adh mRNA levels, indicating PKA-dependent transcriptional regulation of Adh by CrzR. Furthermore, inhibition of PKA or cAMP response element binding protein (CREB) in CrzR cells leads to comparable hangover-like phenotype to the CrzR 01 mutant. These findings suggest that CrzR-associated signaling pathway is critical for ethanol detoxification via Crz-dependent regulation of ALDH activity and Crz-independent transcriptional regulation of ADH. Our study provides new insights into the neuroendocrine-associated ethanol-related behavior and metabolism. © 2014 Sha et al. Source


Patent
Boditech Med Inc. | Date: 2012-03-21

The present invention discloses an integrated sampling and dispensing device comprising a flexible container, a dropper with a sampling rod and a sample removing vessel disposed therebetween. The device of the present invention can be conveniently used for collecting specimen and dispensing the same after a reaction in a single device by simple manipulation of severing the sampling rod and turning the container upside down. Also by using the present device a constant amount of specimen can be used for each reaction which leads to a reliable and reproducible result.


Trademark
Boditech Med Inc. | Date: 2013-10-11

Biochemical precursors for scientific purposes; biochemical preparations for scientific purposes; biochemicals for in vitro and in vivo scientific use; biological preparations, other than for medical or veterinary purposes; biological tissue cultures other than for medical or veterinary purposes; biological tissue specimens for use in scientific research; buffer solutions for scientific purposes; buffer solutions for use in analytical chemistry; chemically treated non-medical test strips for calibration of laboratory apparatus; chemically non-medical treated test strips for assays in biotechnology research; chemical preparations for scientific purposes; chemical preparations for scientific purposes, other than for medical or veterinary use; chemical preparations for use in industry; chemical reagents for scientific purposes; chemical reagents, other than for medical or veterinary purposes; chemicals for use in biotechnological product development; chemicals for use in chromatography; chemicals for use in science; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; diagnostic preparations for scientific or research use; diagnostic preparations, other than for medical or veterinary purposes; diagnostic reagents for scientific or research use; diagnostic reagents, other than for medical or veterinary purposes; enzyme preparations for industrial purposes; enzymes derived from biotechnological processes for use in biotechnology industry; enzymes for scientific and research purposes; reagent paper, other than for medical or veterinary purposes; reagents for chemical analyses; reagents for medical research; reagents for research purposes; reagents for scientific purposes; reagents for use in scientific apparatus for chemical or biological analysis; chemical test paper. Biological and chemical reagents for medical or veterinary purposes; biological reagents for medical purposes or veterinary purposes; chemical reagents for medical or veterinary purposes; clinical diagnostic reagents for medical purposes; swabs for medical purposes or veterinary purposes; diagnostic preparations for medical or veterinary purposes; diagnostic reagents for medical or veterinary purposes; diagnostic substances for medical or veterinary purposes; diagnostic test reagents for medical or veterinary purposes; enzyme preparations for medical or veterinary purposes; enzymes for medical or veterinary purposes; reagent paper for medical or veterinary purposes; medical diagnostic test strips for use in the field of biotechnology; medical diagnostic reagents and assays for testing of bodily fluids. Medical apparatus for clinical diagnosis of cardiac disease, infectious disease, sepsis or anemia; medical apparatus for testing bodily fluid samples; blood testing apparatus; capillary tubes for blood; capillary tubes for delivering reagents; capillary tubes for samples; diagnostic apparatus for medical purposes; incubators for medical purposes.


Trademark
Boditech Med Inc. | Date: 2016-01-20

Laboratory equipment and apparatus for testing chemical composition of test specimen or measuring concentration of test specimen; cartridge for testing chemical composition or measuring concentration of test specimen; computer software for laboratory equipment and apparatus, for testing chemical composition of test specimen or measuring concentration of test specimen; portable equipment and apparatus for fluorescence signal scanning for testing chemical composition of test specimen or measuring concentration of test specimen; computer software for data processing; laboratory instruments for processing test specimen for molecular diagnosis; laboratory instruments for molecular diagnosis; immunoassay cartridge for molecular diagnosis for research purposes; immunoassay cartridge, not for medical purposes; molecular diagnosis cartridge, not for medical purposes; testing equipment and apparatus for biological sample, not for medical purposes; analytical apparatus for automatic analysis of biological sample, not for medical purposes; diagnostic equipment and apparatus, not for medical purposes; in vitro diagnostic cartridge, not for medical purposes; laboratory cartridge for analyzing biological sample; laboratory instrument; computer software for displaying downloadable data generated from medical test or diagnosis apparatus; computer software for analyzing data generated from medical test or diagnosis apparatus; computer hardware for use with medical test or diagnosis apparatus; laboratory instrument for processing test specimen for medical test or diagnosis; computer software for medical test or diagnosis; laboratory instrument for processing test specimen for in vitro diagnosis; laboratory instrument for in vitro diagnosis; cartridge for immunoassay for in vitro diagnosis for research use; computer data processing instrument or facility and software for the aforesaid goods sold as a unit; computer software; computer hardware; equipment and apparatus for fluorescent signal analysis; optical device for scanning fluorescent signal; computer software for equipment and apparatus for fluorescent signal analysis or detection; equipment and apparatus for fluorescent signal detection; equipment and apparatus for absorption measurement; computer software equipment and apparatus for absorption measurement. Immunoassay cartridge for molecular diagnosis for medical purpose; cartridge for testing chemical composition or measuring concentration of test specimen for medical purpose; immunoassay apparatus for medical purposes; immunoassay cartridge for medical purposes; molecular diagnosis apparatus for medical purposes; cartridge for molecular diagnosis for medical purposes; analytical apparatus for automatic analysis of biological sample for medical purposes; cartridge for analyzing biological sample for medical purpose; automated apparatus for analyzing biological sample for medical purpose; equipment and apparatus for processing biological sample for medical purpose; medical apparatus; diagnosis apparatus for medical purposes; in vitro diagnosis apparatus for medical purposes; in vitro diagnosis cartridge for medical purposes; apparatus for fluorescent signal analysis for medical purpose; apparatus for fluorescent signal processing for medical purpose; apparatus for absorption analysis for medical purpose; immunoassay cartridge for in vitro diagnosis for medical purpose.


Trademark
Boditech Med Inc. | Date: 2016-01-20

Immunoassay reagents for scientific or research use; molecular diagnosis reagents for scientific or research use; biological reagents for scientific or research use; biological sample for scientific or research use; testing reagents for biological sample for scientific or research use; reagents for processing biological sample for scientific or research use; biochemical reagents for scientific or research use; reagents for scientific or research use; diagnostic reagents for scientific or research use; in vitro diagnostic reagents for scientific or research use; chemical reagents for scientific or research use; molecular diagnosis test paper or test strips for scientific or research use (other than for medical or veterinary purposes); analytical reagents for laboratory apparatus for molecular diagnosis (other than for medical or veterinary purposes); test paper or test strips for biology or chemistry for scientific or research use (other than for medical or veterinary purposes); test paper or test strips for analyzing biological sample (other than for medical or veterinary purposes); test paper or test strips treated with biochemical sample or chemicals (other than for medical or veterinary purposes); reagent paper (other than for medical or veterinary purposes); test paper or test strips for calibrating laboratory apparatus; test paper or test strips for in vitro diagnosis (other than for medical or veterinary purposes); analytical reagents for laboratory apparatus for in vitro diagnosis (other than for medical or veterinary purposes); immunoassay reagents for antigen-antibody reaction (other than for medical or veterinary purposes); test paper or test strips treated with immunoassay reagents for antigen-antibody reaction (other than for medical or veterinary purposes). Test paper or test strips for molecular diagnosis; analytical reagents for medical apparatus for molecular diagnosis; test paper or test strips for biological specimen or chemicals; test paper or test strips for analyzing biological sample; test paper or test strips treated with biochemical preparations or chemicals; reagent paper for medical purposes; immunoassay reagents for medical or veterinary purposes; molecular diagnosis reagents for medical or veterinary purposes; biological reagents for medical or veterinary purposes; reagents for processing biological sample for medical or veterinary purposes; biological sample for medical or veterinary purposes; biochemical reagents for medical or veterinary purposes; reagents for medical or veterinary purposes; diagnostic reagents for medical or veterinary purposes; in vitro diagnostic reagents for medical or veterinary purposes; chemical reagents for medical or veterinary purposes; reagent for testing biological sample for medical or veterinary purposes; test paper or test strips for calibrating medical apparatus; test paper or test strips for in vitro diagnosis; analytical reagents for medical apparatus used for in vitro diagnosis; immunoassay reagents for antigen-antibody reaction; test paper or test strips treated with immunoassay reagents for antigen-antibody reaction. Laboratory equipment and apparatus for testing chemical composition of test specimen or measuring concentration of test specimen; cartridge for testing chemical composition or measuring concentration of test specimen; computer software for laboratory equipment and apparatus, for testing chemical composition of test specimen or measuring concentration of test specimen; portable equipment and apparatus for fluorescence signal scanning for testing chemical composition of test specimen or measuring concentration of test specimen; computer software for data processing; laboratory instruments for processing test specimen for molecular diagnosis; laboratory instruments for molecular diagnosis; immunoassay cartridge for molecular diagnosis for research purposes; immunoassay cartridge, not for medical purposes; molecular diagnosis cartridge, not for medical purposes; testing equipment and apparatus for biological sample, not for medical purposes; analytical apparatus for automatic analysis of biological sample, not for medical purposes; diagnostic equipment and apparatus, not for medical purposes; in vitro diagnostic cartridge, not for medical purposes; laboratory cartridge for analyzing biological sample; laboratory instrument; computer software for displaying downloadable data generated from medical test or diagnosis apparatus; computer software for analyzing data generated from medical test or diagnosis apparatus; computer hardware for use with medical test or diagnosis apparatus; laboratory instrument for processing test specimen for medical test or diagnosis; computer software for medical test or diagnosis; laboratory instrument for processing test specimen for in vitro diagnosis; laboratory instrument for in vitro diagnosis; cartridge for immunoassay for in vitro diagnosis for research use; computer data processing instrument or facility and software for the aforesaid goods sold as a unit; computer software; computer hardware; equipment and apparatus for fluorescent signal analysis; optical device for scanning fluorescent signal; computer software for equipment and apparatus for fluorescent signal analysis or detection; equipment and apparatus for fluorescent signal detection; equipment and apparatus for absorption measurement; computer software equipment and apparatus for absorption measurement. Immunoassay cartridge for molecular diagnosis for medical purpose; cartridge for testing chemical composition or measuring concentration of test specimen for medical purpose; immunoassay apparatus for medical purposes; immunoassay cartridge for medical purposes; molecular diagnosis apparatus for medical purposes; cartridge for molecular diagnosis for medical purposes; analytical apparatus for automatic analysis of biological sample for medical purposes; cartridge for analyzing biological sample for medical purpose; automated apparatus for analyzing biological sample for medical purpose; equipment and apparatus for processing biological sample for medical purpose; medical apparatus; diagnosis apparatus for medical purposes; in vitro diagnosis apparatus for medical purposes; in vitro diagnosis cartridge for medical purposes; apparatus for fluorescent signal analysis for medical purpose; apparatus for fluorescent signal processing for medical purpose; apparatus for absorption analysis for medical purpose; immunoassay cartridge for in vitro diagnosis for medical purpose.

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