BMC Inc | Date: 2013-03-13
A fall arrest system adapted for use in construction projects with wall studs of various spacing. The fall arrest system comprises a wall attachment bracket and a retractable harness line system, which provides extension, retraction, and storage of a harness line. The harness line is connected to a user-worn harness to protect the user from falling.
Maxwell C.I.,BMC Inc |
Mosey N.J.,Queens University |
Stan Brown R.,Queens University
Journal of the American Chemical Society | Year: 2013
A density functional theory study of the cleavage of a DNA model [p-nitrophenyl methyl phosphate (2)] and two RNA models [p-nitrophenyl 2-hydroxypropyl phosphate (3) and phenyl 2-hydroxypropyl phosphate (4)] promoted by the dinuclear Zn(II) complex of 1,3-bis(1,5,9-triazacyclododec-1- yl)propane formulated with a bridging methoxide (1a) was undertaken to determine possible mechanisms for the transesterification processes that are consistent with experimental data. The initial substrate-bound state of 2:1a or 3:1a has the two phosphoryl oxygens bridging Zn(II) 1 and Zn (II) 2. For each of 2 and 3, four possible mechanisms were investigated, three of which were consistent with the overall free energy for the catalytic cleavage step for each substrate. The computations revealed various roles for the metal ions in the three mechanisms. These encompass concerted or stepwise processes, where the two metal ions with associated alkoxy groups [Zn(II) 1:(-OCH3) and Zn (II) 1:(-O-propyl)] play the role of a direct nucleophile (on 2 and 3, respectively) or where Zn(II) 1:(-OCH3) can act as a general base to deprotonate an attacking solvent molecule in the case of 2 or the attacking 2-hydroxypropyl group in the case of 3. The Zn(II) 2 ion can serve as a spectator (after exerting a Lewis acid role in binding one of the phosphates' oxygens) or play active additional roles in providing direct coordination of the departing aryloxy group or positioning a hydrogen-bonding solvent to assist the departure of the leaving group. An important finding revealed by the calculations is the flexibility of the ligand system that allows the Zn-Zn distance to expand from ∼3.6 Å in 1a to over 5 Å in the transforming 2:1a and 3:1a complexes during the catalytic event. © 2013 American Chemical Society.
Zandi S.,Linkoping University |
Bryder D.,BMC Inc |
Sigvardsson M.,Linkoping University
Immunological Reviews | Year: 2010
The maturation of B-lymphoid cells from hematopoietic stem cells in the bone marrow is a complex process under control of interplay between extrinsic and intrinsic factors. In addition to serving as a model for normal cell differentiation, disturbances in this process results in immunodeficiencies and malignancies, such as leukemia and lymphoma, making the subject of high relevance for modern medicine. Although the process of B lymphopoiesis has been under intense investigation, recent methodological developments within the area of cell sorting, genome-wide expression, and DNA-binding analysis has allowed for a rapid development of the understanding of B-lymphocyte differentiation. This has suggested that the path to B-lymphoid cell fate may be initiated by lineage priming reflected in the expression of lymphoid associated genes already in multipotent hematopoietic progenitors. Upon differentiation, the gene expression profile is changed to involve an increasing number of B-lineage-restricted genes linked to loss of alternative developmental potentials and B-lineage commitment. This review focuses on the molecular regulation of early B-lymphoid development and aims to provide an up to date summary of the current status of the research area. © 2010 John Wiley & Sons A/S.
News Article | June 12, 2015
While Silicon Valley gets most of the press for attracting the world's best geeks, there are 9 other cities to choose from when looking to attract top engineering, data scientists, programmers and other IT experts into your company according to Mintigo, who recently ranked America's top cities for geeks (see infographic below for details). As more and more businesses are driven by their ability to build and/or incorporate mission critical technology into their companies, it's important to know where to find the talent you seek. If having a strong bench of technical talent is key to your success, then consider starting your company in one of these top 10 geekiest cities to ensure your continued talent acquisition and long-term prosperity. Beyond talent acquisition and possible cities to launch your company, what else can you do with this information? Mintigo has some additional predictions based on their findings from this study. While these insights may at first seem a bit farfetched, Mintigo has done a deep dive into the data from the web on millions of companies and using a proprietary algorithm to rank each by the number of tech start-ups, jobs hiring for tech positions, and company deployment of technologies. Location Does Matter Each of these cities has unique characteristics that will shape the technology priorities and build outs. In Silicon Valley, for example, the explosive growth of mobile apps and software as a service were sparked by the great foundational work by Apple and Salesforce.com, respectively. New York, famous for its fashion, finance and food (not to mention theater, transportation and a whole host of other industries), will influence which technological problems are focused on, financed and successfully launched. Our nation's capital will no doubt service the technological needs of the political and legal communities, while Boston will have a gravitational pull toward higher education solutions given the 80 colleges in a one-mile radius of its city. So if you're thinking about where you should start your next company (and you know you're going to need some highly proficient technologists in order to be successful), consider these top 10 geekiest cities and determine which location best suits your talent needs as well as your cultural influences. This should give you a fantastic foundation to build the company you desire.
News Article | August 6, 2015
Nursing programs run by an Education Management Corp. for-profit college face a review by accreditors after an Arizona campus allegedly canceled clinical courses and used veterinary supplies when it ran out of medical equipment. Brown Mackie College will evaluate nursing students at its Tucson location and reteach those deemed deficient at its own expense, under a consent agreement with the Arizona State Board of Nursing. While disputing many of the board’s findings, the college agreed to stop enrolling new students in its practical nursing program in Tucson for at least two years. “It’s the first time we ever did that,” Joey Ridenour, the nursing board’s executive director, said about the retraining order. “It was a very significant action and, based on the findings of the board, it was necessary.” Brown Mackie told its accreditor in the past week that it will shut down the Tucson nursing program after retraining current students, said Anthony Bieda, a spokesman for the Accrediting Council for Independent Colleges and Schools. He said the college failed to report the nursing board’s action in violation of accreditation criteria. ACICS now plans to review all of Brown Mackie’s nursing programs across the country, he said. “We need to be sure that these deficiencies are not systemic and not the way these programs are operated in general,” Bieda said. “We will do our due diligence into how Brown Mackie offers these programs.” Chris Hardman, a spokesman for Education Management, declined to comment about the accreditor’s review or the nursing board’s allegations except to acknowledge that Brown Mackie reached an agreement with the board and that it has ceased enrolling nursing students in Tucson. He said the program currently has about 40 students. “We are committed to ensuring that currently enrolled students in the program receive a quality education that will equip them with the skills and expertise they need to earn a meaningful return on their educational investment,” Hardman said in a statement. For-profit colleges, including Pittsburgh-based Education Management, have been under scrutiny by the federal government and state attorneys general for their recruiting practices and for pushing poor-quality programs that saddle students with debt. The company has denied wrongdoing. Brown Mackie has 25 campuses in 15 states, mostly in the South and Midwest, and runs practical and registered nursing programs at a dozen of them. Its 15-month nursing program in Tucson costs $31,000, and 99 percent of the students take out loans to attend, according to its website. The school’s pass rate for the practical nurses’ licensing exam was 55 percent in the first quarter, below the state’s requirement of 80 percent, the board said. At the Tucson campus, Brown Mackie canceled clinical practice sessions without making up the classes; kept inadequate documentation on attendance and instruction; provided final exam information to students in advance; and failed to provide faculty supervision on a clinical rotation at a local hospice, according to allegations in the settlement agreement, which was signed in May. It also lacked materials including books and “was using veterinarian technician supplies because the BMC did not have enough appropriate supplies,” the board said. In signing the settlement, which didn’t include monetary fines, Brown Mackie admitted that it lacked documentation, repeatedly canceled sessions and provided the nursing board false information on canceled classes. It disputed the other findings, including testing misconduct, failing to provide supervision and the use of vet supplies. The settlement agreement was first reported by the Arizona Daily Star. Arizona’s nursing board has also cited Brown Mackie’s registered nursing program in Phoenix. It sent that campus a Notice of Deficiencies in November saying the school improperly changed student grades, enrolled a student who didn’t meet admission requirements and admonished instructors against talking to the nursing board and accreditors. The board sent another notice in May about the school’s 39 percent graduation rate. Hardman, the company spokesman, declined to comment about the Phoenix program. Besides Brown Mackie, Education Management runs Argosy University, South University and the Art Institutes chain, all for-profit institutions.