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Toronto, Canada

The synthesis and characterization of Zinc complex with glimepiride (an oral antidiabetic drug) has been studied. The conductometric titration using monovariation method indicates that complex is non-ionic and of ML2 type. Analytical data agrees with the molecular formula (C24H 34N4O5S)2 Zn. Structure of the complex was assigned as tetrahedral in which ligand molecules lies horizontally joining the central zinc atom. IR, NMR, Mass spectral and X-ray studies confirm the co-ordination of sulphonyloxygen on one side and enolic oxygen attached from other side with the metal ion. Tentative structure for complex was proposed on the basis of analytical data and Elemental analysis.


Prakash O.,Saifia Science College | Krishan B.,Saifia Science College | Jacob G.,Blyth Academy
Oriental Journal of Chemistry | Year: 2013

Glipizide is a second generation sulphonylurea with promising hypoglycemic activity. It acts by stimulating the release of insulin from β-cells of pancreas. The present paper describes the synthesis and characterization of cerium complex with Glipizide. The conductometric titration using monovariation method reveal that complex is non-ionic and ML2 type which was further confirmed by Job's method of continuous variation as modified by Turner and Anderson. The analytical data agree with the molecular formula (C 21H26N5O4S)2Ce(OH 2)2, that the structure of complex was assigned as octahedral in which ligand molecules lies horizontally joining the central cerium atom. IR, NMR confirms the co-ordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion. The structure of complex was proposed on the basis of analytical data, elemental analysis, IR, 1H NMR and X-ray Diffraction studies.


Prakash O.,Barkatullah University | Jacob G.,Blyth Academy
Oriental Journal of Chemistry | Year: 2013

Present paper deals with the synthesis, spectral characterization and X-ray diffraction study of ZnOl) complex with Pioglitazone a new oral antidiabetic drug. The conductometric titration using monovariation method indicate that complex is ionic and L2M type which was further confirmed by Job's method of continuous variation as modified by Turner and Anderson. Analytical data agree with the molecular formula of complex viz. [(C19H19N 2O3S) 2 Zn]2C1. Structure of complex was assigned as tetrahedral, in which ligand molecules lies horizontally joining the central Zn(II) atom, supported by IR, 1H NMR and Mass studies. X-ray diffraction data also supports the complex formation and symmetry of complex.


Jose S.,Sadhu Vaswani College | Jacob G.,Blyth Academy
Oriental Journal of Chemistry | Year: 2013

Glimepiride is a current, potent hypoglycemic agent used in NIDDM (Non-Insulin Dependent Diabetes Mellitus). Metal complex of glimepiride has been synthesized by reaction with mercury (II) in the form of its chloride. The conductometric titration using mono variation method indicates that complex is non-ionic and ML2 type with was further confirmed by Job's method of continuous variation as modified by Turner and Anderson. Analytical data agrees with the molecular formula (C24H34N4O 5S)2Hg. Structure of the complex was assigned as tetrahedral in which ligand molecules lies horizontally joining the central mercury atom. Infrared spectral and molar conductance data confirm the co-ordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion. Structure assigned to the complex is supported by analytical data and IR and NMR spectral data.

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