Guangzhou, China
Guangzhou, China

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Tanaka Y.,Shingu Municipal Medical Center | Nakashima Y.,Wakayama Medical University | Mima T.,Wakayama Medical University | Ohya M.,Wakayama Medical University | And 14 more authors.
Internal Medicine | Year: 2015

A 29-year-old woman was diagnosed with Henoch-Schönlein purpura nephritis (HSPN) based on the presence of purpura and histopathological findings showing crescent formation, mesangial proliferation and IgA deposition in the glomerular mesangium. She was treated with high-dose steroids; however, the nephritic syndrome persisted. Therefore, we diagnosed her with steroid-resistant HSPN and decided to add treatment with cyclosphamide pulse therapy. After one year of treatment, the histopathological findings, including crescent formation and IgA deposition, improved, as confirmed on a renal biopsy, and the patient fulfilled the criteria for complete remission. Cyclophosphamide pulse therapy may be considered an effective treatment for intractable HSPN. © 2015 The Japanese Society of Internal Medicine.


Xiao C.G.,Blood Purification Center
Zhonghua nei ke za zhi | Year: 2013

To explore the incidence and possible risk factors of restless legs syndrome (RLS) in the maintenance hemodialysis patients. A total of 375 maintenance hemodialysis patients were enrolled in this study from September 1 to 30 in 2012. The diagnosis and assessment of severity were based on the International Restless Leg Syndrome Study Group (IRLSSG) standard. The relevant laboratory parameters and dialysis indicators were collected, such as hemoglobin, serum ferritin, parathyroid hormone, blood flow and dialysis mode. The clinical data were analyzed by multivariate logistic regression method. The incidence of RLS was 13.3% with the severity score of 18.69 ± 0.95. The logistic regression analysis showed that anuria (OR 0.292, 95%CI 0.114-0.750) and β2 microglobulin (OR 1.023, 95%CI 1.003-1.044) were the risk factors for RLS in the maintenance hemodialysis patients, while hemoglobin, serum iron and parathyroid hormone were not correlated with RLS. The incidence of RLS is high in the maintenance hemodialysis patients. The risk factors of RLS are anuria and β2 microglobulin. Therefore, the preservation of residual renal function and the improvement of dialysis adequacy, especially the removal of the middle molecular weight toxins, may reduce the occurrence of RLS and improve the quality of life in the hemodialysis patients.


PubMed | Blood Purification Center
Type: Journal Article | Journal: Zhonghua nei ke za zhi | Year: 2013

To explore the incidence and possible risk factors of restless legs syndrome (RLS) in the maintenance hemodialysis patients.A total of 375 maintenance hemodialysis patients were enrolled in this study from September 1 to 30 in 2012. The diagnosis and assessment of severity were based on the International Restless Leg Syndrome Study Group (IRLSSG) standard. The relevant laboratory parameters and dialysis indicators were collected, such as hemoglobin, serum ferritin, parathyroid hormone, blood flow and dialysis mode. The clinical data were analyzed by multivariate logistic regression method.The incidence of RLS was 13.3% with the severity score of 18.69 0.95. The logistic regression analysis showed that anuria (OR 0.292, 95%CI 0.114-0.750) and 2 microglobulin (OR 1.023, 95%CI 1.003-1.044) were the risk factors for RLS in the maintenance hemodialysis patients, while hemoglobin, serum iron and parathyroid hormone were not correlated with RLS.The incidence of RLS is high in the maintenance hemodialysis patients. The risk factors of RLS are anuria and 2 microglobulin. Therefore, the preservation of residual renal function and the improvement of dialysis adequacy, especially the removal of the middle molecular weight toxins, may reduce the occurrence of RLS and improve the quality of life in the hemodialysis patients.

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