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Kazakova O.B.,RAS Institute of Organic Chemistry | Giniyatullina G.V.,RAS Institute of Organic Chemistry | Medvedeva N.I.,RAS Institute of Organic Chemistry | Lopatina T.V.,RAS Institute of Organic Chemistry | And 3 more authors.
Russian Journal of Bioorganic Chemistry | Year: 2014

3-Deoxy-3a-homo-3a-aza derivatives of betulin and erythrodiol have been synthesized from betulonic and oleanonic acids. 3-Deoxy-3a-homo-3a-aza-28- hydroxy-12(13)-oleanene showed the highest antineoplastic activity of the broad spectrum in vitro; the results of an extensive examination of the derivative in vitro enable one to recommend it for in vivo tests. The modification of the compound in the position C28 by the introduction of a methoxycinnamoyl fragment led to the loss of the antineoplastic activity. As a whole, 3-deoxy-3a-homo-3a- aza derivatives of betulin [3-(aminopropyl)-, 28-(2-carboxyethyl)carboxy-, and 28-cinamoyloxy-] exhibited a moderate antineoplastic activity toward large intestine cancer, breast cancer, and leukemia cells. © 2014 Pleiades Publishing, Ltd.

Lyubchenko L.N.,Blokhin Russian Oncological Research Center
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2011

Li-Fraumeni syndrome (sarcoma family syndrome, OMIM 151623) is a rare clinically and genetically hetergoeneous autosomal dominant disorder characterized by the evolvement and accumulation of softtissue osteogenic sarcomas in members of a family, as well as uni- and bilateral breast cancer in young women, brain tumours, adrenocortical cancer, and lymphoproliferative diseases. Germinal mutations of the TP53 gene constitute the etiological genetic basis of Li-Fraumeni syndrome. American Society of Clinical Oncology (ASCO) and National Comprehensive Cancer Network developed recommendations for genetic testing and observation of carriers of TP53 mutations. In vitro and in vivo studies demonstrated correlation between the TP53-nmtaat genotype and resistance to standard therapeutic modalities. This finding gave impetus to the development of new genotherapeutic approaches to the treatment of TP53-associated tumours in patients with Li-Fraumeni syndrome.

Dolgushin B.I.,Blokhin Russian Oncological Research Center | Nechipai A.M.,Blokhin Russian Oncological Research Center
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2011

A few novel minimally invasive techniques are described for catheter-free repair of internal bile outflow in patients with neoplasms in the biliopancreatoduodenal region complicated by mechanical jaundice and in cases of iatrogenic complications of surgical treatment. The methods based on a combination of modern interventional radiologic and endoscopic technologies allow to improve the outcome of antineoplastic treatment and the quality of life in certain categories of patients. The introduction of these techniques into clinical practice of specialized medical facilities may help to optimize the treatment strategy, reduce the volume of surgery whenever it can be confined to minimally invasive treatment, decrease the employment index, increase the surgical bed turnover rate and other economic characteristics of a surgical clinic.

Davydov M.I.,Blokhin Russian Oncological Research Center | Turkin I.N.,Blokhin Russian Oncological Research Center
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2011

The study was designed to analyse results of D1 - and D2-lymphodissection in 3 94 patients with early stomach cancer between 1990-2007. Risk factors of lymphogenic metastasis (lymphatic invasion, submucous invasion, tumour size in excess of 4 cm, venous invasion, tumour spread to the oesophagus, type 0I and 0II tumors, poor differentiation) are considered to be an absolute indication for D2-lymphodissection that allows to significantly reduce the frequency of relapses and improve the outcome of surgery. The restriction of surgery volume to Dl-lymphodissection is possible only in patients with negligibly low risk of metastasis regardless of the type of early cancer.

Tkachev S.I.,Blokhin Russian Oncological Research Center | Yuryeva T.V.,Blokhin Russian Oncological Research Center | Nechyushkin M.I.,Blokhin Russian Oncological Research Center
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2011

The authors discuss changes in the equipment and technologies of radiotherapy during the past 10-15 years. These changes ensured the improvement of diagnostics and treatment of neoplasms by two other main methods, surgical and medicamental. Modifications in the combined application of radiotherapy and surgery and of radio- and pharmacotherapy are discussed.

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