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Silver Spring, MD, United States

Shu W.-C.,National Chiao Tung University | Wu T.-F.,National Chiao Tung University | Chen R.-H.,National Chiao Tung University | Cheng K.-Y.,Bldg 22 | Hsieh C.-W.,Bldg 22
Advanced Materials Research | Year: 2014

The slot coating process in the production of polymer films has a wide range of applications. However, the process cannot be systemized. This study used the computational fluid dynamics software Polyflow to analyze the slot coating process and investigate the influence that the process parameters have on the characteristics of thin-film coating to reduce the time and cost consumed in the experimental methods. The rheological characteristics of the non-Newtonian fluid used in this study were first identified by conducting experiments, and then configured in the simulation software for fitting with mathematical models. In addition, the models of the slot coating process were constructed, and the Arbitrary Lagrangian-Eulerian (ALE) calculation methods were then used in the Polyflow software. The simulation results were then compared to the experimental results and the findings reported in relevant literature, to determine the influence that the process parameters have on the characteristics of thin-film coating. The simulation results were represented graphically in a coating window plot. The comparison results indicate that the viscosity-shear rate characteristic of the material in the shear rate range of optical film coating is an excellent fit for the Cross Law. When the coating speed is too high or the amount of fluid supply is insufficient, phenomena such as break lines, uneven thickness, and air entrainment can occur. © (2014) Trans Tech Publications, Switzerland.

Chen I.-L.,Bldg 22 | Gao W.-Y.,Bldg 22 | Johnson A.P.,Bldg 22 | Niak A.,Bldg 22 | And 6 more authors.
Journal of Pediatric Gastroenterology and Nutrition | Year: 2012

The Food and Drug Administration has completed its review of 4 clinical trials evaluating the use of proton pump inhibitors (PPIs) in infants (ages 1 month to <12 months) for the treatment of gastroesophageal reflux disease (GERD). An Advisory Committee meeting was held in November 2010 to discuss the potential reasons why PPI use in these trials failed to show a benefit in infants with GERD, and directions for future study. The present review summarizes the findings from the clinical trials. Potential mechanisms for the failed clinical trials are discussed. The safety of long-term use is also discussed. As a result of our analysis and review, the authors agree with the Advisory Committee members that PPIs should not be administered to treat the symptoms of GERD in the otherwise healthy infant without the evidence of acid-induced disease. Copyright © 2012 by European Society for Pediatric Gastroenterology.

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