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Teli A.,Kles J N Medical College | Bagali S.,Bldeus Shri Bm Patil Medical College | Ghatanatti R.,Consultant Cardiac Surgeon
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: Maternal cardiovascular changes in pregnancy are numerous and increase in double product throughout pregnancy is the part of the same process. Double product is a cardinal surrogate of the myocardial oxygen demand and cardiac workload. It is the product of heart rate and systolic blood pressure and an important determinant of cardiovascular risk in hypertensive patients. Aim: This study was intended to determine the double product by comparing normal individuals with different trimesters of pregnancy. Materials and Methods: A cross sectional study was conducted in 220 healthy women in the age range of 18-35 years with 60 subjects each in 1st, 2ndand 3rdtrimesters and 40 non pregnant subjects as control group. Cardiovascular parameters were recorded in both the groups. Statistical analysis was done by comparison of parameters using one-way ANOVA and post-hoc by Tukey-Krammer test. Correlation of double product and weeks of pregnancy was done using Pearson’s correlation. Regression analysis was done to know the predictor of double product. Results: It was observed that there was statistically very highly significant increase (p=0.000) in the double product throughout the pregnancy and duration of pregnancy was found to be the predictor of the product. Conclusion: The increase in the double product is due to increase in heart rate and stroke volume. Double product is the useful predictor for early identification of preeclampsia and acute myocardial infarction in pregnant women when compared to normal non- pregnant women and hence helps in the early management of complications. © 2016, Journal of Clinical and Diagnostic Research. All right reserved.


Balamkar R.,Bldeus Shri Bm Patil Medical College | Shrikhande D.Y.,Pravara Institute of Medical Sciences
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

To determine the role of surfactant in infants with respiratory distress syndrome in rural setup. We retrieved information from the neonates born in our hospital from August 2010 to July 2012 with signs of RDS and gestational age >26wks. Neonates with TTN, Congenital pneumonia and with surgical illness were ruled out. Those infants who received surfactant were taken as Cases and those who did not receive surfactant but managed with only CPAP and ventilator support were taken as Controls. Downe's score (for preterms) and Silverman score (for term neonates) along with chest radiograph was used to assess the severity of RDS and grading was done accordingly. INSURE method was used to instill surfactant followed by nCPAP in Case group and only nCPAP in Control group. Mechanical ventilation (MV) was given in cases requiring it (as per ABG Report). There was significant difference in the outcome of neonates with signs of RDS, who were managed with Surfactant and nCPAP, with or without MV, as compared to those who were managed only with nCPAP, with or without MV but no surfactant. Surfactant administration made a significant difference in the outcome of RDS, with nCPAP. At times MV support was needed but for a shorter duration and lower settings. It is thus recommended that use of surfactant in cases of RDS, particularly moderate to severe cases should become a routine. Respiratory distress syndrome, nasal continuous positive airway pressure, mechanical ventilation.


Hundekari I.A.,Bldeus Shri Bm Patil Medical College | Suryakar A.N.,Maharashtra University of Health Sciences | Rathi D.B.,Maharashtra University of Health Sciences
African Health Sciences | Year: 2013

Background: Pesticide poisoning is an important cause of morbidity and mortality in India. Objectives: To assess the oxidative damage, hemoglobin level and leukocyte count in acute organophosphorus pesticide poisoning. Methods: Plasma cholinesterase was assessed as a toxicity marker. Oxidative damage was assessed by estimating serum malondialdehyde (MDA) levels, plasma total antioxidant capacity (TAC), erythrocyte superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels. Results: Progressive and significant decline (p< 0.001) in plasma cholinesterase in correlation with the severity of organophosphorus poisoning was observed. Serum MDA levels significantly increased (p< 0.001) in all grades of organophosphorus poisoning cases as compared to controls. Erythrocyte SOD, CAT and GPx were significantly increased (p< 0.05) in earlier grade and (p< 0.001) in later grades of organophosphorus poisoning cases as compared to controls. While plasma TAC (p<0.001) was significantly decreased in all grades of organophosphorus poisoning cases as compared to controls. Leucocytosis observed in these cases signifies the activation of defense mechanism which could be a positive response for survival. Conclusion: Organophosphorus compounds inhibit cholinesterase action leading to cholinergic hyperactivity. Increased MDA level may lead to peroxidative damages deteriorating the structural and functional integrity of neuronal membrane. Increased erythrocyte SOD, CAT and GPx activities suggest an adaptive measure to tackle the pesticide accumulation. Hence it is concluded that cholinesterase inhibition may initiate cellular dysfunction leading to acetylcholine induced oxidative damage.


Mangalgi S.,Bldeus Shri Bm Patil Medical College | Sajjan A.,Bldeus Shri Bm Patil Medical College | Mohite S.T.,Krishna University
Journal of Krishna Institute of Medical Sciences University | Year: 2012

Backgroind: In endemic area for brucellosis background levels of antibodies are found in healthy populations. Aims & Objectives: The aim of this study was to determine the seroprevalence of anti-brucella antibodies and base line titres among the blood donors. Materials and Methods: 321 blood samples were collected from blood donors. Serological tests - Rose Bengal Plate Agglutination Test (RBPT), Standard Tube Agglutination Test (STAT) and 2-Mercaptoethanol Agglutination Test (2ME), were carried out on all the blood samples. Results: Seroprevalence of brucellosis in blood donors was 5.91%, 3.11 % and 0.62% by RBPT, STAT and 2ME respectively. History of animal exposure and occasional raw milk ingestion was observed in 137 individuals residing in rural area. Conclusion: Brucellosis might be common in rural population who come in contact with infected animals and or consume raw milk. For the diagnosis of brucellosis RBPT test should be used only for screening purpose and the positive results should be confirmed by STAT and 2ME tests. Titres of 160 IU and above for STAT and 80 IU and above for 2ME test can be considered significant for diagnostic purpose. © Journal of Krishna Institute of Medical Sciences University.


Hundekari I.A.,Bldeus Shri Bm Patil Medical College | Surykar A.N.,Maharashtra University of Health Sciences | Dongre N.N.,Bldeus Shri Bm Patil Medical College | Rathi D.B.,Bldeus Shri Bm Patil Medical College
Journal of Krishna Institute of Medical Sciences University | Year: 2012

Background: Organophosphorus compounds are the pesticides most often involved in human poisoning. Toxicity of these compounds is due to the inhibition of acetyl cholinesterase at cholinergic junctions of the nervous system. Aims & Objectives: Toxicities of OP pesticides cause adverse effects on many organs and systems hence the present study was planned to study the plasma Cholinesterase, serum cholesterol and thyroid function tests in acute organophosphorus pesticide poisoning. Materials and Methods: Plasma ChE, serum cholesterol and serum triiodothyronine, thyroxine, and thyroid stimulating hormone levels were estimated using standard methods. Result: In our study we found the maximum (95%) cases were suicidal poisoning. We found that the incidence of poisoning was more common among age group between 15-35 years and males (57%) were more likely to attempt suicide as compared to females (38%). Among the organophosphorus compounds the most commonly used were dimethoate, monocrotophos, chlorpyriphos. 79% organophosphorus poisoned patients recovered, while 21% died. Plasma Cholinesterase levels were significantly (p<0.001) decreased in all grades of organophosphate poisoning as compared to controls. Inhibition of Plasma Cholinesterase occurs at the time of admission due to toxic effect of organophosphorus compounds; but the levels significantly (p<0.001) normalized after treatment i.e. on the last day of hospitalization. Serum total cholesterol levels significantly decreased (p<0.001) in all grades of organophosphate poisoning cases as compared to controls without any change after treatment as compared with the patients before treatment. There was a slight and nonsignificant decrease in serum triiodothyronine and serum thyroxine levels in organophosphorus poisoning cases without any significant change in serum thyroid stimulating hormone levels as compared to control. The organophosphorus poisoned patients after treatment do not show more changes in their values. Conclusions: The present finding indicate that plasma ChE can be used as a parameter to assess the severity of poisoning and also to monitor the prognosis of OP poisoning. We also support that serum cholesterol estimation can be used as a biological marker in intentional OP poisoning. Acute OP poisoning may not disrupt thyroid hormone metabolism. © Journal of Krishna Institute of Medical Sciences University.

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