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Hundekari I.A.,Bldeas Shri Bm Patil Medical College | Suryakar A.N.,Vmgovt Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2010

Organophosphorus poisoning is a major global health problem with more than 200,000 deaths every year. Organophosphorus compounds are widely used worldwide in agriculture as well as in most household gardens. Unfortunately because of their easy availability and potent toxicity, there is a gradual increase in accidental poisoning and is commonly abused for suicidal purpose. Toxicities of organophosphorus compounds cause oxidative damage of cell membranes and also result in disturbed biochemical and physiological functions. Hence we planned to study the biochemical changes in acute organophosphorus poisoning. Blood samples were collected from the clinically diagnosed organophosphorus poisoning subjects admitted during the year 2007-2009, in Shri B.M. Patil Medical College Hospital and Research Centre, Bijapur. The samples were analyzed using standard methods for different biochemical parameters. Progressive fall in plasma cholinesterase and increased serum malondialdehyde levels in correlation with the severity of organophophorus poisoning were observed. There was significant decrease in serum total cholesterol and potassium levels without much change in serum sodium level. C-reactive protein levels were increased. Serum magnesium levels were decreased in organophosphorus poisoning cases as compared to control group. Inhibition of cholinesterase leads to increased acetylcholine level which induces oxidative damage resulting in various biochemical changes during acute organophophorus poisoning.

Dandin Archana S.,Extension Area | Athanikar V.S.,Bldeas Shri Bm Patil Medical College
Journal of Clinical and Diagnostic Research | Year: 2012

Introduction: H.Pylori has been associated with various upper gastro-intestinal tract disorders including gastritis, peptic ulcer and gastric malignances. There is a paucity of literature regarding the study of morphological changes in H.Pylori associated gastritis, as H.Pylori colonized gastric mucosa is a distinct pathologic entity with a pathologic spectrum ranging from active chronic gastritis to erosions & frank ulcer. Objective: The aim of this study was to know the morphological changes seen in gastric mucosa associated with H.Pylori. And also to fnd out prevalence of H.Pylori in patients undergoing upper gastro-intestinal endoscopic biopsies with gastritis in the centre. Materials and Methods: A total of 100 patients who were clinically diagnosed as having acute or chronic gastritis were included for this study during the period December 2009 to December 2001. A detailed clinical history was taken as per the standard proforma. Then the patients were subjected for endoscopy. Five endoscopic biopsies were taken and processed for rapid urease test and histopathological examination. Results: Out of 100 cases of endoscopically diagnosed gastritis, 48 cases were H pylori positive. In this 48 H.Pylori positive cases, 43 were positive by both rapid urease test (RUT) and histopathology. 3 cases were RUT positive but negative for H pylori by histopathology, and 5 cases were negative by RUT but histopathology showed presence of H pylori. Morphological changes specifc for H.Pylori colonization and characteristic features are irregular surface epithelium, loss of apical mucin, cell dropout, formation of pits and microerosions. Out of 100 cases, 46 were RUT positive and 54 cases RUT negative. 48 were histology positive and 52 were histology negative. Statastically, no signifcant difference between urease test and histopathological demonstration of H.Pylori (p=0.05). Conclusions: Prevalence of H. Pylori in the present study was 48% in patients undergoing upper gastro-intestinal endoscopic biopsies with gastritis in this centre. H.Pylori infection is associated with spectrum of histological changes in gastric mucosa, which in turn facilitates the identifcation of H. Pylori. RUT and histopathology are the 2 diagnostic methods which can be used with an equal importance for the detection of H. Pylori associated lesions.

Irshad Ahamed K.S.,Rajiv Gandhi University of Health Sciences | Shaikh M.,M. S. University of Baroda | Begum S.,Bldeas Shri Bm Patil Medical College | Khan M.I.,Qassim University
Journal of Clinical and Diagnostic Research | Year: 2012

Background and Objectives: Noise pollution in an urban city like Bangalore is a serious problem and is steadily increasing over the years. The relationship between duration of noise exposure and hearing loss in normal subjects residing in an urban city like Bangalore is yet to be investigated. The aim of this study was to determine the relationship between duration of noise exposure and degree of auditory impairment in a crosssectional population of Bangalore city. Methods: 219 normal subjects residing in noisy roads in four geographical areas belonged to the research group were subjected to a pure tone audiometric assessment. The resulting data was statistically analyzed with SPSS software. Results: The auditory threshold (degree of hearing impairment) was very high in subjects which exposed to noise for more than 15 years than the subjects who were exposed to noise below 15 years at the frequencies 1000, 1500, 2000, 3000, 4000, 6000 and 8000 Hz in both ears. Conclusion: The duration of exposure to noise had a direct effect on degree of hearing impairment in subjects of noisy areas. Subjects residing in noisy areas have an increased risk of noise induced hearing loss.

Udasimath S.,HIMS | Arakeril S.U.,Bldeas Shri Bm Patil Medical College | Karigowdar M.H.,Bldeas Shri Bm Patil Medical College | Yelikar B.R.,Bldeas Shri Bm Patil Medical College
Journal of Clinical and Diagnostic Research | Year: 2012

Background: The Cell Block (CB) technique is one of the oldest methods which is used for the evaluation of body cavity fluids. The accurate identification of the cells as either malignant or reactive mesothelial cells is a diagnostic problem in cytological conventional Smears (CS). As compared to the older methods, a new method of cell block preparation which is being used, which uses 10% alcohol-formalin as a fixative, increases the cellularity, gives better morphological details and helps in improving the sensitivity of the diagnosis. Multiple sections can be obtained by the CB method for the special stains and immunohistochemistry studies. Aims: To know the role, utility and the sensitivity of the cell block method in the diagnosis of malignant ascitic fluid effusions. Materials and Methods: This study was conducted in the Cytology Section of the Department of Pathology. 44 peritoneal fluid samples were subjected to a diagnostic evaluation for over a period of 20 months. The cell blocks were prepared by using 10% alcohol-formalin as a fixing agent along with the CS. The cellularity, architectural patterns, morphological details and the cytoplasmic and the nuclear details were studied both in the CS and the CB methods. Mc. Naemer's χ2 test was used to identify the additional yield for malignancy which was obtained by the CB method. Results: The additional yield for malignancy was 13.63% more as was obtained by the CB method. Conclusions: The CB method provides high cellularity, better architectural patterns, morphological details and an additional yield for malignant cells. Therefore, the CB technique could be considered as a useful adjuvant in evaluating the fluid cytology for a final cytodiagnosis, along with the routine CS method.

Kustagi A.V.,Bldeas Shri Bm Patil Medical College | Patil R.M.,Bldeas Shri Bm Patil Medical College
Otorhinolaryngology Clinics | Year: 2012

Chronic tonsillitis is commonly seen in children. Tonsillitis presenting as unilateral pedunculated mass in oral cavity and leading to obstruction of airway is very rare. We report a patient who presented with mass in oropharynx measuring 5 × 2 × 1 cm and review of literature, management and implication of this benign lesion.

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