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Valsād, India

Solankee A.,Bkmscience College | Kapadia K.,Bkmscience College | Ana Ciric,Aristotle University of Thessaloniki | Sokovic M.,Aristotle University of Thessaloniki | And 2 more authors.
European Journal of Medicinal Chemistry | Year: 2010

Base catalysed condensation of ketone 5 with different aldehydes give chalcones, 2.4-bis-(phenylamino)-6-[4′-{3″-(4‴-substituted phenyl/2‴-furanyl/2‴-thienyl)-2″-propenon-1″-y l}phenylamino]-s-thriazines 6a-e. These chalcones on cyclization with hydrazine hydrate in the presence of glacial acetic acid, guanidine nitrate in the presence of alkali and malononitrile in the presence of ammonium acetate give the corresponding acetylpyrazolines 7a-e, aminopyrimidines 8a-e and cyanopyridines 9a-e respectively. The products 6a-e, 7a-e, 8a-e and 9a-e were fully characterized by spectroscopic and elemental analysis and also tested for antibacterial activity. © 2009 Elsevier Masson SAS. All rights reserved.

Solankee A.,Bkmscience College | Patel R.,Bkmscience College
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2014

Some new chalcones, 2,4 bis (tetrahydro-1,4-oxazine)-6-[4-{3"-(substituted phenyl)-2"-propenon-1"-yl} phenyl amino] -s-triazine 6a-f have been achieved by the reaction between 2,4-bis-(tetrahydro-1,4-oxazine)-6-(4'-acetylphenylamino)-s-triazine 5 and different aromatic aldehydes, which on cyclisation with hydrazine hydrate in the presence of acetic acid give acetyl pyrazolines 7a-f. Chalcones 6a-f on cyclisation with guanidine hydrochloride in the presence of alkali give aminopyrimidines 8a-f. The characterization of newly synthesised compounds is based on IR, 1H NMR spectral data as well as elemental analysis. All the synthesised compounds have been screened for their antimicrobial activity.

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