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Patel J.I.,Bk Mody Government Pharmacy College | Deshpande S.S.,Kb Institute Of Pharmaceutical Education And Research
Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry | Year: 2012

Objectives: Bioactivity guided fractionation of leaves of Vitex negundo for their anti-allergic and antioxidant activity and structure elucidation of active fraction responsible for these activities. Methods: Ethyl acetate fraction of leaves of Vitex negundo was fractionated into aqueous sub fraction, acetone sub fraction and chloroform sub fraction according to possible separation of chemical spots present in ethyl acetate fraction using thin layer chromatography and developed solvent system. Anti-allergic activity of aqueous sub fraction, acetone sub fraction and chloroform sub fraction was carried out using homologous passive cutaneous anaphylaxis model in rat. Antioxidant activity of aqueous sub fraction, acetone sub fraction and chloroform sub fraction was carried out using egg albumin induced oxidative stress in guinea pigs. Various spectroscopy methods like Ultraviolet-visible (UV) spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, Electron impact (EI)-Mass spectroscopy and Proton nuclear magnetic resonance (H1 NMR) spectroscopy were used to determine structure of active sub fraction of leaves of Vitex negundo that possesses anti-allergic and antioxidant activity. Results: Aqueous sub fraction produced significant lesser amount of dye leakage at 200 mg/kg (1.6648±0.0372; p<0.001), when compared with the control group (4.0094±0.2474; p<0.001). Animals treated with aqueous sub fraction showed significantly higher superoxide dismutase (SOD) activity, catalase activity and reduced glutathione level and lower malondialdehyde (MDA) level as compared to untreated sensitized animals. Structure of aqueous sub fraction was determined as a 5-hydroxy-3,6,7,3',4'-pentamethoxy flavone. Conclusion: Aqueous sub fraction of leaves of Vitex negundo possesses anti-allergic and antioxidant activity. It is identified as a 5-hydroxy-3,6,7,3',4'-pentamethoxy flavone. It may be useful in the treatment of various allergic and immunologic diseases and to prevent oxidative stress in many diseases like cancer, liver injury, cardiovascular disease, asthma etc. © 2011 Bentham Science Publishers. Source


Chothani D.L.,Bk Mody Government Pharmacy College | Vaghasiya H.U.,Sun Pharma Advanced Research Company SPARC Ltd.
Indian Journal of Natural Products and Resources | Year: 2012

Physalis minima Linn. (Family - Solanaceae) is commonly known as Ground Cherry or Sunberry. It is traditionally used as diuretic, purgative, analgesic, anthelmentic, febrifuge, vermifuge, abortificient, etc. Many steroidal lactones have been identified from the plant and it has been reported to possess antifertility, hypoglycemic, cytotoxic, antiulcer, antibacterial, anti-inflammatory, analgesic, antipyretic, antimalarial, amylase, lipase and alpha glucosidase inhibitor activity and anti-gonorrhoeal activity. Present review summarizes the traditional claims, phytochemistry and pharmacology of P. minima reported so far in scientific literature. Source


Ashara K.C.,Bk Mody Government Pharmacy College | Paun J.S.,Bk Mody Government Pharmacy College | Soniwala M.M.,Bk Mody Government Pharmacy College | Chavada J.R.,Bk Mody Government Pharmacy College | Mori N.M.,Saurashtra University
Asian Pacific Journal of Tropical Disease | Year: 2014

Topical delivery systems for drugs make localized administration of the drug anywhere in the body through ophthalmic, vaginal, skin and rectal routes. Topical formulations encompass a wide variety of formulations intended for cosmetic or dermatological application, to healthy as well as diseased skin. Drugs may be administered for localized or systemic effect. Topical preparations can be formulated with varying physico-chemical properties, as solid, semisolid or liquid. Micro-emulsion of drug is prepared and incorporated into emulgel, having novel topical drug delivery system as dual release control system. Micro-emulsions are micronized; thermodynamically stable systems having low interfacial tension prepared by adding co-surfactant have several features like enhanced permeability, good thermodynemic stability and prolong release. Emulgel prolongs the drug release, increases patient compliance and stability of emulsion. The prepared emulgel is evaluated for various parameteres like pH, viscosity, globule size; spreadability etc. whereas micro-emulsion is evaluated for various parameters like viscosity, pH, zeta-potential etc. © 2014 Asian Pacific Tropical Medicine Press. Source


Dabhi M.,Saurashtra University | Patel S.,Saurashtra University | Mori D.,Bk Mody Government Pharmacy College | Patel D.,Bk Mody Government Pharmacy College | And 2 more authors.
Micro and Nanosystems | Year: 2014

The aim of the present investigation is to develop a stable formulation for Self-Nanoemulsifying Drug Delivery System (SNEDDS) in order to enhance the solubility and release rate of poorly soluble drug (felodipine). Solubility study was performed to select the oil, surfactant and co surfactant in which the drug is had highest solubility. The pseudo-ternary phase diagram was constructed to study the effect of change in a ratio of surfactant/co-surfactant on nanoemulsion formulation and to find emulsification area in phase diagram. The simplex lattice design was used to optimize the formulation and each formulation was evaluated for various physico-chemical formulation parameters like turbidimetric evaluation, droplet size analysis, drug content, effect of dilution and aqueous phase composition, viscosity, pH and self-emulsification. The results indicate that optimized fomulation as per simplex lattice design contained 23.81% oil (Labrafac PG), 57.14% surfactant (Cremophor EL) and 19.05% co-surfactant (PEG-400) having mean droplet size 26.13 nm, emulsification time 13 seconds, and % transmittance 99%. In vitro drug release indicates that more than 80% drug was released in less than 3 min. © 2014 Bentham Science Publishers. Source

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