Bk Mody Government Pharmacy College

Rājkot, India

Bk Mody Government Pharmacy College

Rājkot, India
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Anand S.,Bhagwant University | Sunny S.,Bk Mody Government Pharmacy College
International Journal of Pharmaceutical Research | Year: 2013

Poorly water-soluble drugs such as nifedipine (solubility ~20μ/ml) put forward challenging problems in drug formulation as poor solubility is generally associated to poor dissolution characteristics which may lead to poor oral bioavailability. In order to enhance these characteristics, preparation of nifedipine nanosuspension has been achieved using media milling technique. We investigated the nanoparticle formation of NF via considering the effects of drug-to-stabilizer ratio and amount of beads (zirconium oxide) on the mean particle size, and dissolution properties of NF. It was observed that optimization of drug-tostabilizer ratio and amount of beads allowed the formation of nanosuspensions with a mean particle size of 283 nm. Differential Scanning calorimetry studies confirmed that the crystallinity of the drug was maintained after the particle size reduction suggesting that improved dissolution of NF nanosusensions could be attributed to reduction in particle size.


Patel B.,Smt Rbpatel Mahila Pharmacy College | Patel D.,Bk Mody Government Pharmacy College | Chavda J.,Bk Mody Government Pharmacy College | Manek R.,Bk Mody Government Pharmacy College | Mori D.,Bk Mody Government Pharmacy College
Journal of Chinese Pharmaceutical Sciences | Year: 2013

The present research effort was aimed to develop colon targeted drug delivery system (CTDDS) of rhubarb, herbal drug using a mixed film of pectin and ethyl cellulose (EC). Pectin and ethyl cellulose were mixed in various proportions to coat the core tablet to target colon. The methanolic extract of rhubarb was used and the dose of the extract in each formulation was finalized by estimating the emodin content in it by high performace thin layer chromatography (HPTLC). In vitro drug release, erosion study in presence and absence of pectinase enzyme and release constant (K) of zero order was measured for each formulation. The formulation was optimized by using 32 full factorial design. Formulation having 50% pectin as a coating polymer with 12% coat weight was selected as an optimized formulation (OF) on the basis of % similarity with maximum desirability but this formulation was not able to retard the release of drug in stomach and upper intestine fully. So it was further coated with Eudragit S100 (ES) (3% coat weight). The optimized formulation, coated with ES indicated significant laxative activity on loperamide induced constipation in rats. The results revealed that CTDDS of rhubarb using two combined approaches of biodegrable microfloraactivated system and pHsensitive system exhibited a promising colon targeting performance.


Manek R.A.,Jodhpur National University | Sheth N.R.,Saurashtra University | Vaghasiya J.D.,Jodhpur National University | Malaviya S.V.,Jodhpur National University | Chavda J.R.,Bk Mody Government Pharmacy College
International Journal of Pharmacology | Year: 2011

Synergistic interactions between the components of mixtures of herb are a vital part of their therapeutic efficacy. There is no real basis for better efficacy of a mixture of herb extract than an equivalent dose of an individual herbal extract. Speculation as to explain this, whether it involves synergy, enhanced bioavailability, cumulative effects or simply the additive properties of the constituents requires further research. Liquorice, Kantkari and Vasaka are present in number of herbal formulation available in market for asthma and respiratory disorders so, present study was undertaken to explore the interaction potential of Glycyrrhiza glabra with Solanum xanthocarpum and Adhatoda vasica on mast cell stabilization compound 48/80 and egg albumin induced degranulation. Isobole method and Combination Index values were used to derive possible magnitude of interaction at various combinations. Compound 48/80 and egg albumin significantly disrupted mast cells (p<0.001). Pretreatment of mast cell with Liquorice Extract (LE), Solanum xanthocarpum Extract (SXE) and Adhatoda vasica Extract (AVE) showed significant protection (p<0.05) against Compound 48/80 and egg albumin induced degranulation. This activity of all the extracts was found to be dose dependant. Mast cell treated with various combinations of Adhatoda vasica extract and Liquorice extract (AVE+LE) as well as Solanum xanthocarpum extract and Liquorice extract (SXE+LE), demonstrated significant (p<0.001) stabilization against compound 48/80 and egg albumin induced mast cell degranulation. The isobologram and combination index analysis suggested that combination of LE with SXE and AVE has synergistic effects (and may be nearly additive at some effect level) on mast cell stabilization against compound 48/80 as well as egg albumin degranulation. Thus, it appeared to have substantial activity in this in vitro study, a combination of Liquorice extract with Solanum xanthocarpum extract and Adhatoda vasica extract deserves further clinical investigation in properly designed clinical trials in patients with allergic conditions. © 2011 Asian Network for Scientific Information.


Patel J.I.,Bk Mody Government Pharmacy College | Deshpande S.S.,Kb Institute Of Pharmaceutical Education And Research
International Journal of Green Pharmacy | Year: 2011

To evaluate anti-asthmatic, anti-inflammatory, and anti-allergic activity of various subfractions of ethyl acetate fraction of leaves of Vitex negundo. Ethyl acetate fraction (EAF) of leaves of V. negundo was further subfractionated into NaOH fraction, acetone fraction, and chloroform fraction to separate chemical constituents present in EAF using thin layer chromatography technique and different solvent systems. The stabilisation potential of the various subfractions of EAF of leaves of V. negundo against mast cell degranulation was studied on isolated mesentery of rat by exposure to compound 48/80. Dexamethasone (5 mg/kg) was used as a reference standard. AF of EAF of leaves of V. negundo (500 μg/ml) showed significant protection of rat mesenteric mast cells from disruption caused by compound 48/80. This study concluded that AF of EAF of leaves of V. negundo shows mast cell stabilising activity. It may be useful as anti-asthmatic, anti-inflammatory, and anti-allergic agent.


Mori D.,Bk Mody Government Pharmacy College | Makwana J.,Bk Mody Government Pharmacy College | Parmar R.,Bk Mody Government Pharmacy College | Patel K.,Bk Mody Government Pharmacy College | Chavda J.,Bk Mody Government Pharmacy College
Pakistan Journal of Pharmaceutical Sciences | Year: 2016

The oral bioavailability of felodipine very low, nearly just 15% due to its limited solubility and high first pass metabolism. The present study was aimed to improve the rate of the dissolution of Felodipine by formulating a nano suspension of it by combination of high-speed homogenization and media milling technique. Stabilizers screened in this study were Poloxamer 401, HPMC K15M and Tween 80. Concentration of stabilizers were optimized by simplex lattice design for Mean Particle Size (MPS), Poly dispersity Index (PDI), saturation solubility (SS) and in vitro drug release in 30 min. The particle size of 201 nm and increase in saturation solubility of nearly 9 folds were obtained for optimize batch. The prepared nano suspension of drug was used as a granulating agent to form tablets having Microcrystalline Cellulose (MCC) as diluents. In vitro Drug release study indicates that more than 90% of the drug releases in 30 minutes. Preparing the nano suspension of the low solubility drug is an effective method to increase its saturation solubility. This nano suspension can be prepared effectively by combination of high-speed homogenization and media milling which is also very economical as well.


Ashara K.C.,Bk Mody Government Pharmacy College | Paun J.S.,Bk Mody Government Pharmacy College | Soniwala M.M.,Bk Mody Government Pharmacy College | Chavda J.R.,Bk Mody Government Pharmacy College | And 3 more authors.
Saudi Pharmaceutical Journal | Year: 2016

As compared to gel and other topical preparations microemulgel has been prepared by screening of oils, emulsifier, and co-emulsifier on bases of solubility of an API in it. An API has high solubility and oil may also have more or less pharmacological property, so it may assist the therapeutic action of API. Due to presence of oil portion, it leads to more penetration of API in the skin. Oil Micelle Size was less than 500 nm which provides more area for absorption of API in the skin so more penetration and more effective than macro-emulsion. Microemulgel has an advantage of emulgel that has dual benefits of micro-emulsion and gel and several other desirable properties like good consistency, thyrotrophic, greaseless, easily spreadable as well as removable, emollient, non-staining, water soluble, longer shelf-life, bio-friendly, transparent, pleasant appearance, ability of patients for self-medication, termination of medications will be easy, etc. © 2014 King Saud University


Patel J.I.,Bk Mody Government Pharmacy College | Deshpande S.S.,Kb Institute Of Pharmaceutical Education And Research
Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry | Year: 2012

Objectives: Bioactivity guided fractionation of leaves of Vitex negundo for their anti-allergic and antioxidant activity and structure elucidation of active fraction responsible for these activities. Methods: Ethyl acetate fraction of leaves of Vitex negundo was fractionated into aqueous sub fraction, acetone sub fraction and chloroform sub fraction according to possible separation of chemical spots present in ethyl acetate fraction using thin layer chromatography and developed solvent system. Anti-allergic activity of aqueous sub fraction, acetone sub fraction and chloroform sub fraction was carried out using homologous passive cutaneous anaphylaxis model in rat. Antioxidant activity of aqueous sub fraction, acetone sub fraction and chloroform sub fraction was carried out using egg albumin induced oxidative stress in guinea pigs. Various spectroscopy methods like Ultraviolet-visible (UV) spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, Electron impact (EI)-Mass spectroscopy and Proton nuclear magnetic resonance (H1 NMR) spectroscopy were used to determine structure of active sub fraction of leaves of Vitex negundo that possesses anti-allergic and antioxidant activity. Results: Aqueous sub fraction produced significant lesser amount of dye leakage at 200 mg/kg (1.6648±0.0372; p<0.001), when compared with the control group (4.0094±0.2474; p<0.001). Animals treated with aqueous sub fraction showed significantly higher superoxide dismutase (SOD) activity, catalase activity and reduced glutathione level and lower malondialdehyde (MDA) level as compared to untreated sensitized animals. Structure of aqueous sub fraction was determined as a 5-hydroxy-3,6,7,3',4'-pentamethoxy flavone. Conclusion: Aqueous sub fraction of leaves of Vitex negundo possesses anti-allergic and antioxidant activity. It is identified as a 5-hydroxy-3,6,7,3',4'-pentamethoxy flavone. It may be useful in the treatment of various allergic and immunologic diseases and to prevent oxidative stress in many diseases like cancer, liver injury, cardiovascular disease, asthma etc. © 2011 Bentham Science Publishers.


Chothani D.L.,Bk Mody Government Pharmacy College | Vaghasiya H.U.,Sun Pharma Advanced Research Company SPARC Ltd.
Indian Journal of Natural Products and Resources | Year: 2012

Physalis minima Linn. (Family - Solanaceae) is commonly known as Ground Cherry or Sunberry. It is traditionally used as diuretic, purgative, analgesic, anthelmentic, febrifuge, vermifuge, abortificient, etc. Many steroidal lactones have been identified from the plant and it has been reported to possess antifertility, hypoglycemic, cytotoxic, antiulcer, antibacterial, anti-inflammatory, analgesic, antipyretic, antimalarial, amylase, lipase and alpha glucosidase inhibitor activity and anti-gonorrhoeal activity. Present review summarizes the traditional claims, phytochemistry and pharmacology of P. minima reported so far in scientific literature.


Ashara K.C.,Bk Mody Government Pharmacy College | Paun J.S.,Bk Mody Government Pharmacy College | Soniwala M.M.,Bk Mody Government Pharmacy College | Chavada J.R.,Bk Mody Government Pharmacy College | Mori N.M.,Saurashtra University
Asian Pacific Journal of Tropical Disease | Year: 2014

Topical delivery systems for drugs make localized administration of the drug anywhere in the body through ophthalmic, vaginal, skin and rectal routes. Topical formulations encompass a wide variety of formulations intended for cosmetic or dermatological application, to healthy as well as diseased skin. Drugs may be administered for localized or systemic effect. Topical preparations can be formulated with varying physico-chemical properties, as solid, semisolid or liquid. Micro-emulsion of drug is prepared and incorporated into emulgel, having novel topical drug delivery system as dual release control system. Micro-emulsions are micronized; thermodynamically stable systems having low interfacial tension prepared by adding co-surfactant have several features like enhanced permeability, good thermodynemic stability and prolong release. Emulgel prolongs the drug release, increases patient compliance and stability of emulsion. The prepared emulgel is evaluated for various parameteres like pH, viscosity, globule size; spreadability etc. whereas micro-emulsion is evaluated for various parameters like viscosity, pH, zeta-potential etc. © 2014 Asian Pacific Tropical Medicine Press.


PubMed | Bk Mody Government Pharmacy College and Saurashtra University
Type: Journal Article | Journal: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society | Year: 2016

As compared to gel and other topical preparations microemulgel has been prepared by screening of oils, emulsifier, and co-emulsifier on bases of solubility of an API in it. An API has high solubility and oil may also have more or less pharmacological property, so it may assist the therapeutic action of API. Due to presence of oil portion, it leads to more penetration of API in the skin. Oil Micelle Size was less than 500nm which provides more area for absorption of API in the skin so more penetration and more effective than macro-emulsion. Microemulgel has an advantage of emulgel that has dual benefits of micro-emulsion and gel and several other desirable properties like good consistency, thyrotrophic, greaseless, easily spreadable as well as removable, emollient, non-staining, water soluble, longer shelf-life, bio-friendly, transparent, pleasant appearance, ability of patients for self-medication, termination of medications will be easy, etc.

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