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Prasad H.B.,Clinical Research Site | Puranik S.C.,Clinical Research Site | Kadam D.B.,Clinical Research Site | Sangle S.A.,Clinical Research Site | And 6 more authors.
Journal of Association of Physicians of India | Year: 2011

India reported its first case of H1N1 in July 2009 in Pune and since then, the number of reported cases and deaths exploded in India. Since very little data is available about histopathological findings in patients of H1N1 fatal cases in India, a retrospective chart analysis of necropsy findings of 15 cases of 2009 H1N1 fatal cases was performed. Common clinical features were fever, cough, and breathlessness followed by sore throat and rhinorrhea. Common lung findings were mononuclear cell infiltration, thick alveolar septae, intraalveolar hemorrhage. The other findings were congested pulmonary blood vessels, pulmonary edema, cytomegaly, fibrin accumulation and formation of eosinophilic membrane. These findings are suggestive of diffuse alveolar damage (DAD) and DAD with hemorrhage. All patients who underwent necropsy had radiographic findings suggestive of unilobar or multilobar pneumonia. This clinical finding can be correlated pathologically in these patients as all of them had either polymorphonuclear or mononuclear infiltrate. Furthermore, necrotizing pneumonitis pattern seen on these patients is the likely cause of mortality in these patients. Although clinical ARDS pattern was noted in all these patients, it was well correlated in lung pathology in all these cases. © JAPI.


Bavikar R.,Smt Knmedical College | Kulkarni R.,Bjmedical College
Current Pediatric Research | Year: 2011

we report a case of caroli's syndrome presenting at one year of age. The child had multiple cystic lesions in the liver communicating with intrahepatic bile ducts and multiple bilateral small cysts in kidney with congenital hepatic fibrosis diagnostic of caroli's syndrome.


Vitthal K.R.,MIMER Medical College | Ghongane B.B.,Bjmedical College
International Journal of Pharma and Bio Sciences | Year: 2012

Background: Pain treatment has undergone many strides over past few years and a number of drugs are now available for treatment. These drugs are broadly classified into two groups- Non-narcotic non steroidal anti-inflammatory drugs and Opioids analgesics. These drugs act by different mechanisms and have brought about remarkable changes in the pain treatment. They have abuse liability which is their main drawback and have other adverse effects like respiratory depression. Non steroidal anti-inflammatory drugs have adverse effects like Gastro-intestinal disturbance, prolonged bleeding time, and sodium and water retention. Hence the search for an ideal analgesic drug continues. Buspirone is a 5HT1A receptor partial agonist and mainly used in the treatment of anxiety and depression5,7. It has shown marked analgesic effect in tail - flick and hot plate tests on rats. Buspirone produced significant analgesia. In some studies 5HT1A agonist shows hyperalgesic effect6. In view of this contradictory findings analgesic activity of Buspirone needs to be evaluated and its mechanism of action needs to be explored.


Parikh U.R.,Bjmedical College | Goswami H.M.,Bjmedical College | Deliwala K.J.,Bjmedical College | Shah A.M.,Bjmedical College | Barot H.P.,Bjmedical College
Journal International Medical Sciences Academy | Year: 2012

Infertility is one of the major problems in developed as well as many developing countries. About fifteen percent of all marriages face the problem of infertility. A study of semen analysis and testicular biopsy was done in 80 infertile male. History of smoking was encountered in 29 (34.12%) cases, 56 (70%) patients were clinically normal in terms of testis and scrotum. Varicocele (41.67%) was the most common positive clinical finding responsible for infertility. Though the specific reason for sertoli cell only syndrome is not known, it was the most common abnormal histopathological finding (18.75%), followed by maturation arrest, testicular atrophy and granulomatous inflammation of testis (11.25% each). On semen analysis, 71.25% cases had azoospermia, 24.71% cases had oligospermia and 2.35% cases had normal sperm count. Oligospermia is usually associated with inflammatory etiology. Among oligospermics and normospermics, the sperm motility was more than 50% in 14 patients (60.67%). Among the azoospermic patients, 35.09% showed normal spermatogenesis in their testicular biopsy. Although azoospermia is commonly associated with normal spermatogenesis, it is a hallmark of sertoli cell only syndrome (SCOS), testicular atrophy and maturation arrest. Thus, testicular biopsy is invaluable in the azoospermics but its usefulness is limited in the oligospermics.


Deo S.V.,Galaxy Care Hospital | Deo S.V.,Bjmedical College | Puntambekar S.P.,Galaxy Care Hospital
Indian Journal of Surgery | Year: 2013

Gastric cancer remains an important cause of cancer-related deaths and a complete margin-negative (R0) resection remains the only potentially curative treatment for gastric adenocarcinoma. We report a case of carcinoma of distal stomach in a 48-year-old male patient who was diagnosed on UGI endoscopy and CT scan. He had symptoms suggestive of gastric outlet obstruction due to stenosing lesion. He was successfully treated with laparoscopic distal gastrectomy with D2 lymphadenectomy. Laparoscopic distal gastrectomy is justified by its feasibility, early recovery, oncological safety, and improved quality of life in cancer stomach. © Association of Surgeons of India 2012.


Prajapati B.,Bjmedical College | Kedia B.K.,Bjmedical College | Patel N.,Bjmedical College | Patel D.,Bjmedical College | And 2 more authors.
Gujarat Journal of Otorhinolaryngology and Head and Neck Surgery | Year: 2012

Objective: To report a minimally invasive surgical technique for repair of tympanic membrane. Study design: Transcanal approach studied in 50 cases of tympanoplasty using tragal perichondrial graft & fibrin glue with onlay technique. All patients were assessed for postoperative graft take up, hearing improvement, pain and cosmetics. Methods: We had selected patients who have central perforation with dry ear and wide external auditory canal and who were concerned for post aural scar, shaving and postoperative bandage. Onlay technique was done in all cases with perichondrial graft with or without fibrin glue. After 3 months all patients were examined for graft take up and PTA was performed. Results: There was graft take up of 89% without glue and 96% with glue. Conclusion: Transcanal tympanoplasty is a minimally invasive surgical technique for repair of small and medium size tympanic membrane perforation. The procedure is simple and obviates the need for large postaural incision.


Bhalodiya N.H.,Bjmedical College | Gupta D.,Bjmedical College | Makwana B.,Bjmedical College | Shah S.,Bjmedical College | Shah H.,Bjmedical College
Gujarat Journal of Otorhinolaryngology and Head and Neck Surgery | Year: 2012

Immotile-cilia syndrome is a rare disorder characterized by chronic recurrent sino-pulmonary infection, impaired tracheobronchial clearance, situsinversus in about 50% of cases, and living but immotile spermatozoa of normal morphology in semen analysis. It is an unusual presentation of immotile-cilia syndrome with azoospermia in a 35-year-old male patient. The diagnosis was based on history of recurrent respiratory tract infection, bronchiectasis, maxillary sinusitis, impaired nasal mucociliary clearance, etc. Semen analysis revealed azoospermia without any evidence of obstruction in epididymides or vas deference. Normal spermatogenesis was seen on testicular biopsy.


Goswami N.N.,Baroda medical college | Goswami N.N.,Bjmedical College | Gandhi A.M.,Baroda medical college | Gandhi A.M.,Bjmedical College | And 4 more authors.
Journal of Applied Pharmaceutical Science | Year: 2014

Present study evaluates the effects of antipsychotic medications on metabolic parameters in patients suffering from psychiatric illness. The study was carried out at tertiary care teaching hospital, department of psychiatry after obtaining written informed consent from the patients. They were randomized into three groups - Group I (n=31) (haloperidol 10 mg/day, orally), Group II (n=34) (risperidone 4-6 mg/day, orally) and Group III (n=38) (olanzapine 10 mg/day, orally). Metabolic parameters [fasting blood sugar (FBS), post prandial blood sugar (PP2BS), glycosylated haemoglobin (HbA1c), serum cholesterol, triglyceride, low density lipoprotein (S.LDL) and high density lipoprotein (S.HDL)] were measured at the end of 3 and 6 months. Data was analysed using a suitable statistical tests. In group II significant changes (p<0.05) were observed in FBS, HBA1C, cholesterol, S.LDL and S.HDL while in group III significant changes (p<0.05) were observed in all the metabolic parameters at the end of 6 months. In group III, FBS, PP2BS, HbA1C, Serum cholesterol, triglyceride and S.LDL levels were increased 9.41%, 7.09%, 8%, 6.25%, 7.68% and 9.92% respectively, at the end of 6 months. Patients treated with haloperidol showed minimum changes in metabolic parameters at the end of 6 months. Olanzapine is associated with more disturbances in metabolic parameters as compared to risperidone and haloperidol. © 2014 Nimit Nitinkumar Goswami et al.

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