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Shivajinagar, India

Panse N.,Bj Government Medical College | Sahasrabudhe P.,Bj Government Medical College
Indian Journal of Plastic Surgery | Year: 2014

Background: The introduction of perforator flaps by Koshima et al. was met with much animosity in the plastic surgery fraternity. The safety concerns of these flaps following the intentional twist of the perforators have prevented widespread adoption of this technique. Use of perforator based propeller flaps in the lower extremity is gradually on the rise, but their use in upper extremity reconstruction is infrequently reported, especially in the Indian subcontinent. Materials and Methods: We present a retrospective series of 63 free style perforator flaps used for soft tissue reconstruction of the upper extremity from November 2008 to June 2013. Flaps were performed by a single surgeon for various locations and indications over the upper extremity. Patient demographics, surgical indication, defect features, complications and clinical outcome are evaluated and presented as an uncontrolled case series. Results: 63 free style perforator based propeller flaps were used for soft tissue reconstruction of 62 patients for the upper extremity from November 2008 to June 2013. Of the 63 flaps, 31 flaps were performed for trauma, 30 for post burn sequel, and two for post snake bite defects. We encountered flap necrosis in 8 flaps, of which there was complete necrosis in 4 flaps, and partial necrosis in four flaps. Of these 8 flaps, 7 needed a secondary procedure, and one healed secondarily. Although we had a failure rate of 12-13%, most of our failures were in the early part of the series indicative of a learning curve associated with the flap. Conclusion: Free style perforator based propeller flaps are a reliable option for coverage of small to moderate sized defects. Level of Evidence: Therapeutic IV. Source

Bhosale M.,Bj Government Medical College | Singh D.,Bj Government Medical College
Journal of Indian Association of Pediatric Surgeons | Year: 2016

A 3-day-old male neonate delivered at 34 weeks of gestational age was brought with breathing difficulty since birth. The abdomen was massively distended. A soft cystic mass was occupying almost the entire abdomen and causing obvious respiratory distress. On exploration, a huge, solitary, unilocular cyst was found between the two lobes of the liver. Growing extrahepatically between the two lobes, it had displaced them laterally on either side. Enucleation of the cyst and marsupialization of its base was done. Histopathology showed evidence of congenital solitary nonparasitic cyst of the liver. Symptomatic presentation of CSNCL in children, especially in a neonate is extremely rare and not considered as a differential diagnosis of an abdominal mass. Hence, the case report. Source

Kulkarni A.A.,Bj Government Medical College | Thakur S.S.,Bj Government Medical College
Journal of Clinical and Diagnostic Research | Year: 2015

Malignant tumours of the submandibular salivary glands are rare entities. Most common malignant tumour of submandibular gland is mucoepidermoid carcinoma. Histological finding of squamous cell carcinoma is very rare in submandibular salivary gland. Metastasis from distant primary squamous malignancy, direct invasion from cutaneous or mucosal squamous carcinoma, squamous component of mucoepidermoid carcinoma or primary squamous cell carcinoma of salivary origin are some of the possible causes. Of these, the latter is distinctly uncommon. Primary squamous malignancy is diagnosed only after ruling out other possible explanations. A positive mucin stain in the tumour or synchronous/ metachronous squamous carcinoma elsewhere excludes the diagnosis of a primary carcinoma. Primary squamous carcinoma is seen most commonly in parotid gland and rarely in submandibular gland. We present a case of primary squamous cell carcinoma of right submandibular salivary gland in a 45-year old-man. This case is presented for the rare entity of primary squamous cell carcinoma in submandibular salivary gland. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved. Source

Walujkar S.A.,National Center for Cell Science | Walujkar S.A.,Bj Government Medical College | Dhotre D.P.,National Center for Cell Science | Marathe N.P.,National Center for Cell Science | And 3 more authors.
Gut Pathogens | Year: 2014

Background: The healthy human intestine is represented by the presence of bacterial communities predominantly belonging to obligate anaerobes; however disparity and dysanaerobiosis in intestinal microflora may lead to the progression of ulcerative colitis (UC). The foremost aim of this study is to consider and compare the gut microbiota composition in patients suffering from different stages of UC. Methods. This study represents data from the biopsy samples of six individuals suffering from UC. The samples were collected by colonoscopy and were processed immediately for isolation of DNA. Mucosal microbiota was analyzed by means of 16S rRNA gene-based Illumina high throughput sequencing. Quantitative real-time PCR (qPCR) was performed to determine total bacterial abundances. Results: Analysis of 23,927 OTUs demonstrated a significant reduction of bacterial diversity consistently from phylum to species level (p < 0.05) for individuals suffering from severe stage of UC. Significant increase in abundance of unusual aerobes and facultative anaerobes, including members from the phylum Proteobacteria (p- = 0.031) was also observed. A 10 fold increase in the total bacterial count was detected in patients suffering from severe inflammatory stage (2.98 +/-0.49 E + 09/ml) when compared with patients with moderate (1.03+/-0.29 E + 08/ml) and mild (1.76 +/-0.34 E + 08/ml) stages of inflammation. Conclusion: The reduction of bacterial diversity with an increase in the total bacterial count indicates a shift of bacterial communities which signifies dysbiosis and dysanaerobiosis at the mucosal level for patients suffering from UC. © 2014 Walujkar et al.; licensee BioMed Central Ltd. Source

Dhar M.H.,Bj Government Medical College | Shah K.U.,Grant Government Medical College | Ghongane B.B.,Bj Government Medical College | Rane S.R.,Bj Government Medical College
International Journal of Pharma and Bio Sciences | Year: 2013

Gentamicin and Ceftazidime are commonly used antibiotics, but their use is limited by potential nephrotoxicity. In the present study, the nephroprotective activity of Crocus sativus was evaluated against Gentamicin and/or Ceftazidime-induced renal toxicity. Ethanolic extract of stigmas of Crocus sativus was administered (i.p.) once daily to albino rats 30 min. before administration of Gentamicin or Ceftazidime (i.m.) alone and in combination for 10 days. Nephrotoxicity was assessed by estimation of biochemical parameters, 24 hrs urine output, urinalysis, Erythrocyte Sedimentation Rate (ESR), body and kidney weights; and kidney histopathology were evaluated. Extract alone had no significant effect. In gentamicin-treated rats, body weights and urine output were significantly lower than control rats; along with marked proteinuria, significant increase in blood urea, serum creatinine, ESR and kidney weights with changes in serum electrolytes. This nephrotoxicity was confirmed by histopathology. Ceftazidime induced similar but lesser damage. Their combination induced toxicity greater than individual drugs. These changes were prevented by the extract of Crocus sativus - a promising nephroprotective agent. Source

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