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Schaumburg, IL, United States

Kim Y.K.,Kyungpook National University | Gu L.-S.,Sun Yat Sen University | Bryan T.E.,Georgia Regents University | Kim J.R.,Kyung Hee University | And 6 more authors.
Biomaterials | Year: 2010

The complex morphologies of mineralised collagen fibrils are regulated through interactions between the collagen matrix and non-collagenous extracellular proteins. In the present study, polyvinylphosphonic acid, a biomimetic analogue of matrix phosphoproteins, was synthesised and confirmed with FTIR and NMR. Biomimetic mineralisation of reconstituted collagen fibrils devoid of natural non-collagenous proteins was demonstrated with TEM using a Portland cement-containing resin composite and a phosphate-containing fluid in the presence of polyacrylic acid as sequestration, and polyvinylphosphonic acid as templating matrix protein analogues. In the presence of these dual biomimetic analogues in the mineralisation medium, intrafibrillar and extrafibrillar mineralisation via bottom-up nanoparticle assembly based on the non-classical crystallisation pathway could be identified. Conversely, only large mineral spheres with no preferred association with collagen fibrils were observed in the absence of biomimetic analogues in the medium. Mineral phases were evident within the collagen fibrils as early as 4 h after the initially-formed amorphous calcium phosphate nanoprecursors were transformed into apatite nanocrystals. Selected area electron diffraction patterns of highly mineralised collagen fibrils were nearly identical to those of natural bone, with apatite crystallites preferentially aligned along the collagen fibril axes. © 2010.

Bisco Inc. | Date: 2012-02-16

A hydrophobic self-etch dental adhesive composition including a hydrophobic, surfactant-type acidic monomer. The composition may further include hydrophilic and hydrophobic monomers, preferably in a ratio of less than 1:1, and may include a solvent that is an azeotrope.


Bisco Inc. | Date: 2014-08-27

Dental materials, namely, dental desensitizers.

Bisco Inc. | Date: 2014-08-27

Dental materials, namely, root canal repair and restorative materials.

Bisco Inc. | Date: 2014-07-31

Dental materials, namely, dental pulp capping, lining and restorative materials.

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