Birla Institute of Technology and Science

www.bits-pilani.ac.in
Pilani, India

Birla Institute of Technology & Science is an Indian institute of higher education and a deemed university under Section 3 of the UGC Act. The university has 15 academic departments, and focuses primarily on undergraduate education in engineering and the science.The institute was established in its present form in 1964. During this period, the institute's transformation from a regional engineering college to a national university was backed by G.D. Birla. BITS has established centres at Goa,Pilani,Hyderabad and Dubai.BITS administers the all-India computerised competitive entrance examination, BITSAT , Admission is merit-based, as assessed by the BITSAT examination. The fully residential institute is privately supported. Wikipedia.

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Patent
Indian Council Of Medical Research, Birla Institute of Technology and Science | Date: 2017-04-26

This invention relates to a test strip for holding reagents to determine blood glucose level, said strip comprising a) a plasma separator membrane which is a composite membrane for separation of plasma from whole blood, said plasma separator membrane containing an enzyme mix specific to the analyte, said analyte being glucose, a substrate which reacts specifically with one of the products of the enzymatic reaction of the analyte with the enzyme mix, b) a reaction membrane containing an enhancer mix of metallic ions, which enhances the color developed due to the enzymatic reaction.


Patent
Indian Council Of Medical Research, Birla Institute of Technology and Science | Date: 2015-06-18

This invention relates to a test strip for holding reagents to determine blood glucose level, said strip comprising a) a plasma separator membrane which is a composite membrane for separation of plasma from whole blood, said plasma separator membrane containing an enzyme mix specific to the analyte, said analyte being glucose, a substrate which reacts specifically with one of the products of the enzymatic reaction of the analyte with the enzyme mix, b) a reaction membrane containing an enhancer mix of metallic ions, which enhances the color developed due to the enzymatic reaction.


Biswas S.,Northeastern University | Biswas S.,Birla Institute of Technology and Science | Torchilin V.P.,Northeastern University
Advanced Drug Delivery Reviews | Year: 2014

To efficiently deliver therapeutics into cancer cells, a number of strategies have been recently investigated. The toxicity associated with the administration of chemotherapeutic drugs due to their random interactions throughout the body necessitates the development of drug-encapsulating nanopreparations that significantly mask, or reduce, the toxic side effects of the drugs. In addition to reduced side effects associated with drug encapsulation, nanocarriers preferentially accumulate in tumors as a result of its abnormally leaky vasculature via the Enhanced Permeability and Retention (EPR) effect. However, simple passive nanocarrier delivery to the tumor site is unlikely to be enough to elicit a maximum therapeutic response as the drug-loaded carriers must reach the intracellular target sites. Therefore, efficient translocation of the nanocarrier through the cell membrane is necessary for cytosolic delivery of the cargo. However, crossing the cell membrane barrier and reaching cytosol might still not be enough for achieving maximum therapeutic benefit, which necessitates the delivery of drugs directly to intracellular targets, such as bringing pro-apoptotic drugs to mitochondria, nucleic acid therapeutics to nuclei, and lysosomal enzymes to defective lysosomes. In this review, we discuss the strategies developed for tumor targeting, cytosolic delivery via cell membrane translocation, and finally organelle-specific targeting, which may be applied for developing highly efficacious, truly multifunctional, cancer-targeted nanopreparations. © 2013 Elsevier B.V.


Islam S.H.,Birla Institute of Technology and Science
Information Sciences | Year: 2015

Recently, the theory and application of Chebyshev polynomials have been studied extremely by the cryptographic research community; many symmetric and asymmetric cryptographic protocols have been designed based on extended chaotic maps. In this paper, a computation cost efficient and robust three party password-based authenticated key exchange (ECM-3PAKE) protocol with key confirmation has been designed using extended chaotic maps and smartcard. In this protocol, two users can establish a common session key with the help of a trusted server. The proposed protocol is shown to be provably secure in the random oracle model and formally validated through the simulation of Automated Validation of Internet Security Protocols and Applications (AVISPA) software. The simulation results from different model checkers of AVISPA proved that the protocol can withstand the active and passive attacks. Besides, the informal security analysis gives the evidence of security and functional efficiencies of the protocol. In addition, the comparative analysis illustrates that the protocol performs better than the existing protocols. © 2015 Elsevier Inc. All rights reserved.


Cycloaddition/annulation reactions remain the most attractive methods for the synthesis of five membered heterocyclic ring systems. Among the three possible strategies for [3 + 2] cycloaddition, this review focuses on 1,3-carbon donor-acceptor (C3, D-A) cycloaddition/annulation reactions with imines to synthesize pyrrolidines. The formal [3 + 2] cycloaddition, which includes the in situ 1,3-carbon D-A precursor generation through metal catalysis, Lewis acid catalysis and organocatalysis approaches is highlighted. The scope and limitations of this strategy along with its applications in the synthesis of natural product alkaloids reported during the last decade are outlined. © 2014 the Partner Organisations.


Srinivas M.,Birla Institute of Technology and Science
Renewable and Sustainable Energy Reviews | Year: 2011

Following typical phases of any technology development, initially there have been research works focusing mainly on the solar hot water systems' (SHWS) technology development then followed by economic aspects. This has resulted in techno-economically feasible standardized solar hot water systems. Owing to these favourable features, SHWS in general and Domestic SHWS (DSHWS) in particular attracted several promotional measures with a view to make them as the alternative for conventional water heating options in India. However, even after the implementation of these measures for more than two decades in India, the potentials-achievements difference remains to be extremely large, the reasons for which are attributed to the so-called "barriers for dissemination". This paper presents a consolidated review of solar water heating related issues covering these technological developments, techno-economics, promotional measures, present dissemination status and barriers for dissemination, all with a special reference to the Indian context. Also presented in this paper is the identified need for "viability" studies of DSHWS and "essentials for viability evaluations of DSHWS" in multi-dimensional environment that aid in developing decision making tools to improve dissemination of DSHWS. © 2011 Elsevier Ltd. All rights reserved.


Maiti D.K.,Birla Institute of Technology and Science
Ocean Engineering | Year: 2012

Numerically simulated results are presented for a family of rectangular cylinders (placed parallel to a wall and subjected to a uniform shear flow) with aspect ratios r (=b/a with height a and width b) ranging from 0.1 to 1.0 (square cylinder) to gain a better insight into the dependency of the aerodynamic characteristics on the operational dimensionless parameters, namely aspect ratio r, gap height L and Reynolds number Re. The governing unsteady Navier-Stokes equations are solved numerically through SIMPLE algorithm with the QUICK scheme for convective terms. The critical Reynolds numbers at which an alternating vortex shedding commences from each of the rectangular cylinder are specified for different gap heights. A special attention is paid to search a rectangular cylinder of suitable thickness to produce the stronger vortices in the wake. The present numerical results are certified with some previous numerical and experimental findings. © 2012 Elsevier Ltd.


Tripathi D.,Birla Institute of Technology and Science
Computers and Mathematics with Applications | Year: 2011

This paper presents the effect of endoscope on peristaltic transport of fractional Maxwell fluids through the gap between two concentric uniform tubes under the assumptions of large wavelength and low Reynolds number. The inner tube is an endoscope and the outer tube has a sinusoidal wave traveling down its wall, i.e. the inner tube is rigid and outer tube is flexible. Solutions for the problem are obtained by two numerical methods named as homotopy perturbation method and variational iteration method. The impacts of endoscope, relaxation time and fractional parameters on pressure per wavelength and friction force (on inner and outer tubes) per wavelength are discussed with the help of computational results which are presented in graphical form. On the basis of the present study, it is revealed that pressure diminishes with increase in the magnitude of first fractional parameter, ratio of tube radii and relaxation time whereas it enhances with increasing the magnitude of second fractional parameter and amplitude ratio. The study further reveals the important fact that the effects of all pertinent parameters (except ratio of tube radii) on friction force at inner tube are similar in magnitude but opposite in direction to that of pressure and the effects of same parameters on friction force at outer tube are similar in magnitude but opposite in direction to that of pressure. © 2011 Elsevier Ltd. All rights reserved.


Gupta N.,Birla Institute of Technology and Science
Materials and Design | Year: 2011

This paper presents a material selection approach for selecting absorbent layer material for thin-film solar cells (TFSCs) using multiple attribute decision making (MADM) approach. In this paper, different possible materials for absorbent layer and their properties like band gap, absorption coefficient, diffusion length, thermodynamic compatibility and recombination velocity is taken into consideration and MADM approach is applied to select the best material for thin-film solar cells. It is observed that Copper Indium Gallium Diselinide (CIGS) is the best material for the absorbent layer in thin-film solar cells out of all possible candidates. It was observed that the proposed result is in accordance with the experimental findings thus justifying the validity of the proposed study. © 2010 Elsevier Ltd.


Singh M.,Birla Institute of Technology and Science | Jadhav H.R.,Birla Institute of Technology and Science
Drug Discovery Today | Year: 2014

Melatonin is a chronobiotic substance that acts as synchronizer by stabilizing bodily rhythms. Its synthesis occurs in various locations throughout the body, including the pineal gland, skin, lymphocytes and gastrointestinal tract (GIT). Its synthesis and secretion is controlled by light and dark conditions, whereby light decreases and darkness increases its production. Thus, melatonin is also known as the 'hormone of darkness'. Melatonin and analogs that bind to the melatonin receptors are important because of their role in the management of depression, insomnia, epilepsy, Alzheimer's disease (AD), diabetes, obesity, alopecia, migraine, cancer, and immune and cardiac disorders. In this review, we discuss the mechanism of action of melatonin in these disorders, which could aid in the design of novel melatonin receptor ligands. © 2014 Elsevier Ltd. All rights reserved.

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