Kalyān, India
Kalyān, India

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Patil A.,Birla College | Patil D.,Smt CHM College | Ansari A.,Birla College | Koli S.,Birla College
Indian Journal of Traditional Knowledge | Year: 2013

To obtain effective drug with proven efficacy, it is necessary to establish standards through modern scientific and technical procedures which would certainly enhance the reputation and acceptance of traditional medicines. Sufoof-e-mohazzil, a unani polyherbal formulation is used by Unani physicians for treatment of obesity. The present work involves standardization of Sufoof-e-mohazzil in order to assess the quality of In-house and marketed formulations. In-house and marketed formulations were subjected to pharmacognostic studies, physico-chemical properties, phytochemical analysis and HPTLC fingerprint profile to set the standards, which can be used as reference standard to evaluate the quality control in herbal industries and to overcome batch to batch variations in traditional preparation. In the present study, the anatomical markers fibro vascular tissue, endospermic cells, vittae, pitted vessels and group of sclereids from the mesocarp were observed. The extractive values were found to be more for alcohol than water. The preliminary phytochemical analysis indicated presence of alkaloids, fats and fixed oils, essential oils, glycosides, resins and saponins. HPTLC fingerprint profile of formulations showed a characteristic pinkish red band of Thymol at Rf of 0.43.


Khandpekar M.M.,University of Mumbai | Dongare S.S.,University of Mumbai | Satpute P.P.,Birla College | Pati S.P.,Sambalpur University
Optics Communications | Year: 2011

Transparent crystals of α-glycine with barium nitrate and calcium nitrate (GBC) have been grown from aqueous solution by slow evaporation technique at room temperature. Crystals of size 22 × 25 × 4 mm 3 have been obtained in 3-4 weeks time. The solubility of GBC has been determined in water. The grown crystal belongs to orthorhombic system with cell parameters a = 12.7321 A.U, b = 13.7752 A.U and c = 8.6002 A.U with unit cell volume of 1508.36 (A.U)3. Comparative IR and Raman studies indicate a molecule with a lack of center of symmetry. A wide transparency window useful for optoelectronic applications is indicated by the UV Studies. Using Nd:YAG laser (1064 nm), the optical second harmonic generation (SHG) conversion efficiency of GBC is found to be 0.702 times than that of standard KDP. On exposure to light the GBC crystals exhibit positive photoconductivity. I-V characteristics, dielectrics studies, electrical and Vickers micro hardness measurement have been carried out. The GBC crystal exhibits more mechanical strength compared to the reported GSN crystals. © 2011 Elsevier B.V.


Shah W.,Vartak College | Patil U.,Birla College | Sharma A.,Birla College
Der Pharma Chemica | Year: 2014

In the present work silver nanoparticles was synthesized from stem bark extract of Terminalia tomentosa Roxb. (Wight & Arn.), a plant widely found in a large region in India, as reducing agent. Terminalia tomentosa Roxb. (Wight & Arn.) is known to be rich in antioxidant molecules which was used as reducing agents. Silver nanoparticles grow in a single-step method, at room temperature, and with no addition of external energy. The nanoparticles have been characterized by ultraviolet-visible spectroscopy and transmission electron microscopy, as a function of the ratio of silver ions to reducing agent molecules. The nanoparticles diameters were found to be in the range of 5 to 50 nm. The synthesized silver nanoparticles from the Terminalia tomentosa Roxb. (Wight & Arn.) stem bark extract, which do not involve any harmful chemicals were well-dispersed.


Gupta A.D.,Birla College | Karthikeyan S.,Dr Ambedkar Government Arts College
Ecotoxicology and Environmental Safety | Year: 2016

Ni and Cr are ubiquitous pollutants in the aquatic environments. These heavy metals elicit toxicities to aquatic organisms including microbes. In this study, interaction of the two heavy metals on the toxicity in Escherichia coli (E. coli) was studied using FTIR spectroscopy. The binding of Ni(II) to E. coli was stronger than that for Cr(VI). Cr exhibited antagonistic effects in the presence of Ni in E. coli. FTIR analysis showed a decrease in lipid content in the presence of Ni and not for Cr. Further, a decrease in band area was observed in the region of 3000–2800 cm−1 and at ~1455 cm−1 due to a decrease in fatty acids and lipid molecules. The band area ratio of lipid was used to monitor the changes in fatty acids due to metal toxicity. Principle component method helps to discriminates the results between control and metal toxicities in E. coli from the FTIR data. The study shows the importance of metal interaction and its toxicity on E. coli. © 2016 Elsevier Inc.


Patil A.G.,Birla College | Joshi K.A.,Birla College | Patil D.A.,Birla College | Chandra N.,Birla College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

The use of plant as medicine is as old as human civilization. Exploration of this traditional knowledge for cures to common diseases is an attractive prospect. Cardiospermum halicacabum L commonly known as 'Balloon vine' has many associated utilities, including a remedy for joint pain. The tender, young shoots are used as a vegetable, fodder, diuretic, stomachic and rubefacient. It is used in rheumatism, lumbago, nervous diseases and as a demulcent in orchitis and in dropsy. In many regions this plant is harvested in backyards for both medicinal and food value. To get information about correct identification of the stem of this plant pharmacognostical and physico-chemical studies, as well as phytochemical analysis and HPTLC fingerprint were carried out. Anatomical studies revealed presence of covering trichomes, anomocytic stomata, pitted as well as spiral thickening of vessels and fibres. Various physico-chemical parameters such as total ash, water soluble ash, acid insoluble ash and extractive values were carried out. Preliminary phytochemical analysis and TLC showed presence of saponin, tannins, flavanoids, glycosides and cardiac glycosides. This study will provide referential pharmacognostical, physico-chemical and phytochemical information for correct identification of Cardiospermum halicacabum L. stem. © 2010 RJPBCS.


Lobo V.,Birla College | Patil A.,Birla College | Phatak A.,Birla College | Chandra N.,Birla College
Pharmacognosy Reviews | Year: 2010

In recent years, there has been a great deal of attention toward the field of free radical chemistry. Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence application of external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years. The present review provides a brief overview on oxidative stress mediated cellular damages and role of dietary antioxidants as functional foods in the management of human diseases.


Patil A.G.,Birla College | Koli S.P.,Birla College | Patil D.A.,Birla College | Chandra N.,Birla College
International Journal of Pharma and Bio Sciences | Year: 2010

Crataeva tapia Linn. ssp. odora (Jacob.) Almeida, a traditional medicinal plant, which is valued for its benefits in the management of urinary and inflammatory disorders. Leaves are externally rubefacient and used in rheumatism; internally they are given as febrifuge and tonic. The leaves also act as anti-periodic. The current study was therefore carried out to provide requisite pharmacognostic details about the leaves of C. tapia. Pharmacognostic evaluation included examination of morphological and microscopical characters; physicochemical properties, phytochemical analysis, fluorescence study and HPTLC finger print. The powder microscopy showed the presence of anomocytic stomata and spiral thickening. Phytochemical screening reported the presence of tannins, steroidal compounds, cardiac glycosides and alkaloids. The Rf value of 0.35 detected at 300 nm and 600 nm by qualitative densitometric HPTLC fingerprint, can be used as identifying marker for methanolic extract. The present study will provide the information with respect to identification and authentication of crude drug.


Dhaliwal M.K.,Birla College | Chandra N.,Birla College
Indian Journal of Geo-Marine Sciences | Year: 2016

Marine red yeasts were enriched and isolated using sea-water samples from different locations as well as various marine animals. Two red yeast isolates selected were studied for their carotenoids production. Two selected isolates were identified as Rhodosporidium paludigenum and Sporobolomyces novazealandicus based on their cultural, morphological and biochemical characters. The isolates were studied for their carotenoid content using HPTLC and HPLC. The Rhodosporidium paludigenum isolate was observed to produce β-carotene only, whereas isolate Sporobolomyces novazealandicus produced higher amounts of total carotenoids, with an additional pigment. © 2016, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.


The roots of Ephedra foliata have a long cap. The root apical meristem can be distinguished into (1) a discrete layer of stelar initials, (2) the columella and its initials, and (3) a common initiating region for the cortex and the peripheral region of the cap. The study of the cell lineages brings out that the first zone and its derivatives show a Krper complex of cells, the second and its derivatives divide in a transverse plane, and the third zone exhibits the Kappe complex.This organization resembles the gymnospermous type mentioned in the older literature in the discreteness of the plerome.A possible line of evolution of the root apical structures of gymnosperms is suggested.


PubMed | Birla College and Electronic Arts
Type: | Journal: Ecotoxicology and environmental safety | Year: 2016

Ni and Cr are ubiquitous pollutants in the aquatic environments. These heavy metals elicit toxicities to aquatic organisms including microbes. In this study, interaction of the two heavy metals on the toxicity in Escherichia coli (E. coli) was studied using FTIR spectroscopy. The binding of Ni(II) to E. coli was stronger than that for Cr(VI). Cr exhibited antagonistic effects in the presence of Ni in E. coli. FTIR analysis showed a decrease in lipid content in the presence of Ni and not for Cr. Further, a decrease in band area was observed in the region of 3000-2800cm(-1) and at ~1455cm(-1) due to a decrease in fatty acids and lipid molecules. The band area ratio of lipid was used to monitor the changes in fatty acids due to metal toxicity. Principle component method helps to discriminates the results between control and metal toxicities in E. coli from the FTIR data. The study shows the importance of metal interaction and its toxicity on E. coli.

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