Birkbeck, University of London is a public research university located in London, United Kingdom and a constituent college of the federal University of London. It offers many Master's and Bachelor's degree programmes that can be studied either part-time or full-time, though nearly all teaching is in the evening. It also admits full-time students for PhDs. Wikipedia.
McMahon H.T.,University of Cambridge |
Boucrot E.,Birkbeck, University of London
Journal of Cell Science | Year: 2015
Membrane curvature is an important parameter in defining the morphology of cells, organelles and local membrane subdomains. Transport intermediates have simpler shapes, being either spheres or tubules. The generation and maintenance of curvature is of central importance for maintaining trafficking and cellular functions. It is possible that local shapes in complex membranes could help to define local subregions. In this Cell Science at a Glance article and accompanying poster, we summarize how generating, sensing and maintaining high local membrane curvature is an active process that is mediated and controlled by specialized proteins using general mechanisms: (i) changes in lipid composition and asymmetry, (ii) partitioning of shaped transmembrane domains of integral membrane proteins or protein or domain crowding, (iii) reversible insertion of hydrophobic protein motifs, (iv) nanoscopic scaffolding by oligomerized hydrophilic protein domains and, finally, (v) macroscopic scaffolding by the cytoskeleton with forces generated by polymerization and by molecular motors.We also summarize some of the discoveries about the functions of membrane curvature, where in addition to providing cell or organelle shape, local curvature can affect processes like membrane scission and fusion as well as protein concentration and enzyme activation on membranes. © 2015. Published by The Company of Biologists Ltd.
Barker E.D.,Birkbeck, University of London
Journal of child psychology and psychiatry, and allied disciplines | Year: 2010
It is increasingly recognized that youth who follow early onset persistent (EOP), childhood limited (CL) and adolescent onset (AO) trajectories of conduct problems show somewhat varying patterns of risk (in childhood) and adjustment problems (in adolescence and adulthood). Little, however, is known about how other adjustment problems differentially co-develop with the EOP, CL and AO trajectories across the childhood and adolescent years. Using data from the Avon Longitudinal Study of Parents and Children, an epidemiological, longitudinal cohort of boys and girls, we estimated growth curves for parent-reported hyperactivity, emotional difficulties, peer relational problems, and prosocial behaviors conditional on trajectories of conduct problems (i.e., EOP, CL and AO) from ages 4 to 13 years. At ages 7-8 years, DSM-IV-based diagnoses of conduct disorder, oppositional-defiant disorder, attention deficit/hyperactivity disorder (ADHD), anxiety, depression were examined by conduct problems trajectory. Overall, the development of hyperactivity, emotional difficulties, peer relational problems, and prosocial behaviors mirrored the development of conduct problems, showing similar trajectories. Results indicated that the problems of EOP youth were persistent across domains, CL youth showed decreased behavior problems while increasing in prosocial behaviors, and AO youth increased in adjustment problems after 10 years of age. © 2010 The Authors. Journal of Child Psychology and Psychiatry © 2010 Association for Child and Adolescent Mental Health.
Lorch M.,Birkbeck, University of London
Cortex | Year: 2011
The 150th anniversary affords an opportunity to revisit the circumstances surrounding Paul Broca's case report celebrated today as the moment of discovery of aphasia. The proceedings from January to June 1861 of the Paris Society of Anthropology are examined to reconstruct the events surrounding the report of M. Leborgne on April 18th. From a close reading of the presentations and discussions which took place during this period it is apparent that Broca's case report was a minor diversion to a debate about cranial measurements and their relation to intelligence in individuals and racial groups. Moreover, it appears that little attention was granted to Broca's first case at the time. While his ideas about localization and specialization developed and change over the next decade, it represented a minor field of interest for him. Nevertheless Broca's work on aphasia inspired research throughout Europe and North America and went on to have a lasting impact on both aphasiology and neuropsychology. © 2011 Elsevier Srl.
Vermeesch P.,Birkbeck, University of London
Chemical Geology | Year: 2012
Since the development of SIMS and LA-ICP-MS technologies in the 1980s and 1990s, single grain U-Pb dating of detrital zircon has quickly become the most popular technique for sedimentary provenance studies. Currently by far the most widespread method for visualising detrital age distributions is the so-called Probability Density Plot (PDP), which is calculated by summing a number of Gaussian distributions whose means and standard deviations correspond to the individual ages and their respective analytical uncertainties. Unfortunately, the PDP lacks a firm theoretical basis and can produce counter-intuitive results when data quantity (number of analyses) and/or quality (precision) is high. As a more robust alternative to the PDP, this paper proposes a standard statistical technique called Kernel Density Estimation (KDE), which also involves summing a set of Gaussian distributions, but does not explicitly take into account the analytical uncertainties. The Java-based DensityPlotter program (http://densityplotter.london-geochron.com) was developed with the aim to facilitate the adoption of KDE plots in the context of detrital geochronology. © 2012 Elsevier B.V.
Sullivan S.,Birkbeck, University of London
Antipode | Year: 2013
In this paper I emphasise the financialisation of environmental conservation as 1. the turning of financiers to conservation parameters as a new frontier for investment, and 2. the rewriting of conservation practice and nonhuman worlds in terms of banking and financial categories. I introduce financialisation as a broadly controlling impetus with relevance for environmental conservation. I then note ways in which a spectacular investment frontier in conservation is being opened. I highlight the draw of assertions of lucrative gains, combined with notions of geographical substitutability, in creating tradable indicators of environmental health and harm. I disaggregate financialisation strategies into four categories-nature finance, nature work, nature banking and nature derivatives-and assess their implications. The concluding section embraces Marx and Foucault as complementary thinkers in understanding the transforming intensifications of late capitalism in environmental conservation, and diagnosing their associated effects and costs. © 2012 The Authors. Antipode © 2012 Antipode Foundation Ltd.