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Dhaka, Bangladesh

Latif Z.A.,BIRDEM | Jain A.,Novo Nordisk AS | Rahman M.M.,Novo Nordisk AS
Bangladesh Medical Research Council Bulletin

DiabCare Bangladesh 2008 evaluated the current status of diabetes care in Bangladesh as a continuation of similar cross-sectional study conducted previously in 1998. The current study recruited 1952 patients from general hospitals, diabetes clinics and referral clinics to study current scenario of diabetes management from 01 March 2009 to 31 March 2009. We report the results of type 2 diabetic population who constituted 95.3% (n=1860). Results showed deteriorating glycaemic control with mean HbA1c of 8.6±2.0% with only 23.1% of the patients achieving American Diabetes Association (ADA) target of <7%. 896 (47.0%) patients were hypertensive and 850 (94.9%) were on antihypertensive medication. 70.8% of patients had LDL levels >2.6 mmol/L; 43.8% had triglycerides >2.2 mmol/L; 44.1% had HDL<1 mmol/L despite 48% of the patients being on lipid lowering agents. Microvascular, macrovascular and severe late complications were reported in 39.2%, 9.9% and 12.1% patients respectively. The rates of diabetic complications were cataract 12.9%, microalbuminuria 15.7%, neuropathy symptoms 31.7%, leg amputation 1.2% and history of angina pectoris was 6.6%. Quality of life evaluation showed that about half of patients have poor quality of life. Also, there was poor adherence to diet, exercise and self testing of blood glucose. In conclusion, majority of the patients were still not satisfactorily controlled. There is an urgent need for effective remedial measures to increase adherence to practice guidelines and to educate both patients and healthcare personnel on importance of achieving clinical targets for metabolic control. Source

Hossain S.J.,Khulna University | Basar M.H.,Khulna University | Rokeya B.,BIRDEM | Arif K.M.T.,Khulna University | And 3 more authors.
Oriental Pharmacy and Experimental Medicine

The mangrove fruit Sonneratia apetala Buch.-Ham. is extensively consumed by the people of coastal Bangladesh especially adjacent to the Sundarbans' forest. Seeds consist of very high content of polyphenols (300 ± 8.2 mg GAE/g extract), flavonoids (30.6 ± 0.7 CE/g extract), anthocyanins (2.3 ± 0.03 μmol/g extract) and vitamin C (4.0 ± 0.08 mg/g extract). The IC50 values for DPPH and NO free radical scavenging were 4.3 and 49.4 μg/mL for seed extract and that for pericarp extract were 59.8 and 751.6 μg/mL respectively. Seed extract also showed very high reducing power (O. D. 1.14 at 50 μg/mL extract) and total antioxidant capacity (280.8 GAE or 310.24 AAE/g extract). In streptozotocin (STZ) induced type 2 diabetes rats, seed extract treated group showed serum glucose decreased from 13.75 ± 2.21 mmol/L (at 30 min) to 10.3 ± 1.75 mmol/L (at 135 min) and in the pericarp treated group from 14.36 ± 2.16 to 11.32 ± 1.74 mmol/L. The area under the glucose curve was more profoundly decreased in the seed treated group than the pericarp treated group. Susceptibility test showed that seed extract inhibited the growth of both gram-positive and gram-negative pathogenic bacteria. Therefore, fruits of S. apetala, especially its seeds are functionally rich with phenolics, flavonoids, antioxidant, antidiabetic and antibacterial compounds. © 2012 Institute of Oriental Medicine, Kyung Hee University. Source

Tsai S.-T.,Taipei Veterans General Hospital | Pathan F.,BIRDEM | Ji L.,Peking University | Yeung V.T.F.,Center for Diabetes Education and Management | And 7 more authors.
Journal of Diabetes

Background: The First Basal Insulin Evaluation (FINE) Asia study is a multinational, prospective, observational study of insulin-naïve Type 2 diabetes mellitus (T2DM) patients in Asia, uncontrolled (A1c≥8%) on oral hypoglycemic agents, designed to evaluate the impact of basal insulin initiation. Methods: Basal insulin was initiated with or without concomitant oral therapy and doses were adjusted individually. All treatment choices, including the decision to initiate insulin, were at the physician's discretion to reflect real-life practice. Results: Patients (n=2679) from 11 Asian countries were enrolled (mean [±SD] duration of diabetes 9.3±6.5years; weight 68.1±12.7kg; A1c 9.8±1.6%). After 6months of basal insulin (NPH insulin, insulin glargine, or insulin detemir), A1c decreased to 7.7±1.4%; 33.7% patients reached A1c <7%. Fasting blood glucose (FBG) decreased from 11.7±3.6 to 7.2±2.5mmol/L and 36.8% of patients reached FBG <6.1mmol/L. The mean daily insulin dose prescribed increased marginally from 0.18 to 0.23U/kg per day at baseline to 0.22-0.24U/kg per day at Month 6. Mean changes in body weight and reported rates of hypoglycemia were low over the duration of the study. Conclusions: Initiation of insulin therapy is still being delayed by approximately 9years, resulting in many Asian patients developing severe hyperglycemia. Initiating insulin treatment with basal insulin was effective and safe in Asian T2DM patients in a real-world setting, but insulin needs may differ from those in Western countries. © 2011 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. Source

Akhter M.,Bangabandhu Sheikh Mujib Medical University | Ali L.,Bangladesh Institute of Health Science | Hassan Z.,BIRDEM | Khan I.,BIRDEM
Journal of Health, Population and Nutrition

Oral squamous cell carcinoma is the sixth most common malignancy worldwide. In Bangladesh, it comprises 20% of the whole body malignancies. Several studies found that 15% to 25% of oropharyngeal cancer cases are associated with human papilloma virus (HPV). This study is done to find the association of human papilloma virus subtypes, particularly HPV type 16 and HPV type 18, with the oral squamous cell carcinoma in Bangladeshi patients. In total, 34 diagnosed patients of oral squamous cell carcinoma were included in the study. Extracted DNA from the cancerous tissues was checked for PCR reaction to detect the subtypes of human papilloma virus. Data of the present study suggest that oral squamous cell carcinoma are almost absent in Bangladeshi patients with human papilloma virus, particularly HPV 16 and 18. © INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH. Source

Begum R.,BIRDEM | Khanum S.,BIRDEM
Bangladesh Journal of Obstetrics and Gynecology

A 30years of old hypothyroid lady, presented with foul smelling excessive whitish per vaginal discharge, associated with itching in vulva & pain in the lower abdomen following caesarean section 3 months back. Her uterus was palpably enlarged and firm. USG revealed bulky uterus with wall echo shadow sign. A CT scan of whole abdomen was done that revealed intra-uterine textiloma. During laparotomy huge amount of pus came out through wound and a mob was found within uterine cavity. Textiloma is a rare problem of surgery arising from retained gauze during operation. Careful counting of surgical gauze before closure and identification by newer techniques is required to prevent this iatrogenic complication. Source

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