Entity

Time filter

Source Type

Zurich, Switzerland

Colella L.,Ecole Polytechnique Federale de Lausanne | Beyer C.,ETH Zurich | Frohlich J.,ETH Zurich | Talary M.,Biovotion | Renaud P.,Ecole Polytechnique Federale de Lausanne
Bioelectrochemistry | Year: 2012

The dielectric response of biconcave erythrocytes exposed to d-glucose and l-glucose has been investigated using a double array of planar interdigitated microelectrodes on a glass microchip. Erythrocytes are analyzed under physiological conditions suspended in hypo-osmolar balanced solutions containing different glucose concentrations (0-20. mM). The glucose effect on the cellular dielectric properties is evaluated by analyzing the spectra using two different approaches, the equivalent circuit model and a modified model for ellipsoidal particles. The results show that at elevated glucose concentration (15. mM) the membrane capacitance increases by 36%, whereas the cytosol conductivity slightly decreases with a variation of about 15%. On the contrary, no variation has been registered with l-glucose, a biologically inactive enantiomer of d-glucose. The paper discusses the possible mechanism controlling the membrane dielectric response. As the external d-glucose increases, the number of activated glucose transporter in the erythrocyte membrane raises and the transition from sugar-free state to sugar-bounded state induces a change in the dipole moments and in the membrane capacitance. © 2011 Elsevier B.V. Source


Embodiments of the present invention comprise systems and methods for noninvasion measurements of physiological properties of tissues. The system comprises a light emitter, an optical detector, a mechanical sensor and a processor. The light emitter is capable of emitting light of at least two different wavelengths and comprises at least one light source. The processor is capable of evaluating physiological properties of the tissues from measurements of the optical and the mechanical sensor. More precisely, the processor is capable of evaluating physiological properties of venous blood by using data measured by the mechanical sensor and the optical detector. For example, the oxygenation of venous blood can be measured. Furthermore, the systems can optionally comprise a light emitter which emits three wavelengths and/or the light emitter and the optical detector are arranged in reflection geometry and are located at a distance of at most 10 mm from each other.


Biovotion | Entity website

Please consider updating your browser The full website can only be accessed by a more recent browser. On Windows, beginning January 12, 2016, only the most current version of Internet Explorer will receive technical support and security updates from Microsoft ...


Biovotion | Entity website

Please consider updating your browser The full website can only be accessed by a more recent browser. On Windows, beginning January 12, 2016, only the most current version of Internet Explorer will receive technical support and security updates from Microsoft ...


Biovotion | Entity website

Please consider updating your browser The full website can only be accessed by a more recent browser. On Windows, beginning January 12, 2016, only the most current version of Internet Explorer will receive technical support and security updates from Microsoft ...

Discover hidden collaborations