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Patent
Bioventus and Fujifilm Co. | Date: 2016-10-21

Methods of purifying TGF- superfamily proteins, including osteogenic proteins such as bone morphogenetic proteins (BMPs), are disclosed.


Patent
Bioventus | Date: 2016-12-30

The present disclosure relates to compositions useful in synthetic bone graft applications. Particularly, the disclosure teaches moldable bone graft compositions, methods of making said compositions, and methods of utilizing the same.


Browse 66 tables and 67 figures, 15 Company profiles spread across 153 pages available at: The global bone growth stimulators market is estimated to reach USD 1.41 billion by 2022, growing at a CAGR of 5.4% during the forecast period. The growing patient preference for non-invasive and minimally invasive surgical treatments, increasing target patient population (including rising aging population and prevalence of obesity and diabetes) and cost-effectiveness and advantage of bone stimulation devices in bone fracture treatments over other alternative treatment options are some key factors propelling the growth of this market. In this report, the market has been segmented on the basis of product, end user, application, and region. On the basis of application, the global bone growth stimulators market is segmented into spinal fusion surgeries, delayed union and non-union bone fractures, dental and maxillofacial surgeries, and other applications. In 2016, the spinal fusion surgeries segment accounted for the largest share of the market. This growth can be attributed to the established safety and efficacy of stimulators in fusion surgery, rising patient cases related to bone fracture, and growing number of spine procedures performed across the globe. On the basis of product, the global market is segmented into bone growth stimulation devices, bone morphogenetic protein (BMPs), and platelet-rich plasma (PRP). The PRP segment is expected to grow at the highest CAGR during the forecast period primarily owing to the increasing use of PRP in sports injuries and the expansion of its applications (due to a growing number of clinical trials). On the basis of application, the global bone growth stimulator market is segmented into spinal fusion surgeries, delayed union and non-union bone fractures, dental and maxillofacial surgeries, and other applications. The spinal fusion surgeries segment is expected to grow at the highest CAGR during 2017 to 2022, owing to the growing geriatric population, rising number of spine procedures (and rate of spinal fusion failure), established safety and efficacy of stimulators in fusion surgery, and increasing use of bone growth stimulation products. On the basis of end user, the global bone growth stimulator market is segmented into hospitals & clinics, home care, and academic & research institutes and CROs. In 2016, the hospitals & clinics segment accounted for the largest of the market. The advantages of bone growth stimulation products over their counterparts are the key factor driving their adoption in this end-user segment. Geographically, North America commanded the largest share of the global bone growth stimulators market in 2016, followed by Europe. The growing elderly population, increasing incidence of arthritis and sports-related injuries, adoption of novel treatment options, and rising demand for minimally invasive spinal surgeries are some of the major factors driving the demand for bone growth stimulators in North America. Order a copy of Bone Growth Stimulator Market by Product (Device, Boner Morphogenetic Protein, PRP), Application (Spinal Fusion, Delay Union & Non-union Bone Fracture, Oral-maxillofacial), End User (Hospitals, Home Care, Academia, CROs) - Global Forecasts to 2022 Research Report At: Orthofix International N.V. (U.S.), Medtronic plc (Ireland), Zimmer Biomet Holdings, Inc. (U.S.), DJO Finance LLC (U.S.), Bioventus LLC (U.S.), Stryker Corporation (U.S.), DePuy Synthes (U.S.), Arthrex, Inc. (U.S.), Isto Biologics (U.S.), and Harvest Technologies Corporation (U.S.) are some of the players operating the bone growth stimulator market. Explore more reports on Medical Devices market at: ReportsnReports.com is an online market research reports library of 500,000+ in-depth studies of over 5000 micro markets. Not limited to any one industry, ReportsnReports.com offers research studies on agriculture, energy and power, chemicals, environment, medical devices, healthcare, food and beverages, water, advanced materials and much more.


News Article | April 24, 2017
Site: www.businesswire.com

DURHAM, N.C.--(BUSINESS WIRE)--Bioventus has named David Varner Vice President of Marketing, Active Healing Therapies.


News Article | May 4, 2017
Site: www.prnewswire.co.uk

Browse 66 market data Tables and 67 Figures spread through 153 Pages and in-depth TOC on "Bone Growth Stimulator Market" Early buyers will receive 10% customization on this report. On the basis of product, the global Bone Growth Stimulators Market is segmented into bone growth stimulation devices, bone morphogenetic protein (BMPs), and platelet-rich plasma (PRP). The bone growth stimulation devices segment accounted for the largest share of the market in 2016. This large share is attributed to the growing aging population, rising preference for non-surgical treatment procedures, and growing prevalence of nonunion fractures. Additionally, the rising incidence of obesity, smoking, and diabetes which delay or inhibit bone healing after surgery or trauma are further driving the market growth. On the basis of application, the global Bone Growth Stimulators Market is segmented into spinal fusion surgeries, delayed union and nonunion bone fractures, oral and maxillofacial surgeries, and other applications. The spinal fusion surgeries segment accounted for the largest share of the market in 2016. The large share of this segment is attributed to the growing geriatric population, rising number of spine procedures (and rate of spinal fusion failure), established safety and efficacy of stimulators in fusion surgery, and increasing use of bone growth stimulation products. On the basis of end user, the global Bone Growth Stimulators Market is segmented into hospitals & clinics, home care, and academic & research institutes and CROs. The hospitals & clinics segment is expected to grow at the highest CAGR during the forecast period. The advantage of bone growth stimulation products over their counterparts is the key factor driving their adoption in this end-user segment. On the basis of region, this Bone Growth Stimulators Market is classified into North America, Europe, Asia-Pacific, and the Rest of the World. In 2016, the global Bone Growth Stimulators Market was dominated by North America mainly due to the growing elderly population, increasing incidence of arthritis and sports injuries, adoption of novel treatment options, and rising demand for minimally invasive spinal surgeries. However, the Asia-Pacific market is expected to grow at the highest CAGR during 2017-2022. This is primarily due to the presence of a large patient population for target diseases (coupled with rapidly growing geriatric population, especially in Japan and China), rising awareness among healthcare professionals related to novel and upcoming treatment options, and ongoing government initiatives to modernize & expand healthcare infrastructure. Orthofix International N.V. (U.S.), DJO Finance LLC (U.S.), Zimmer Biomet Holdings, Inc. (U.S.), Bioventus LLC (U.S.), Medtronic plc (Ireland), Stryker Corporation (U.S.), DePuy Synthes (U.S.), Arthrex, Inc. (U.S.), and Harvest Technologies Corporation (U.S.) are some of the key players in the Bone Growth Stimulators Market. Spinal Implants and Surgical Devices Market by Technology (Fusion, Fixation, VCF, Decompression, Motion Preservation), Product (Thoracic, Lumbar, Cervical, Interbody, Kyphoplasty, Artificial Discs, MIS, Biologics, Stimulators) - Global Forecast to 2022. MarketsandMarkets™ provides quantified B2B research on 30,000 high growth niche opportunities/threats which will impact 70% to 80% of worldwide companies' revenues. Currently servicing 5000 customers worldwide including 80% of global Fortune 1000 companies as clients. Almost 75,000 top officers across eight industries worldwide approach MarketsandMarkets™ for their painpoints around revenues decisions. Our 850 fulltime analyst and SMEs at MarketsandMarkets™ are tracking global high growth markets following the "Growth Engagement Model - GEM". The GEM aims at proactive collaboration with the clients to identify new opportunities, identify most important customers, write "Attack, avoid and defend" strategies, identify sources of incremental revenues for both the company and its competitors. MarketsandMarkets™ now coming up with 1,500 MicroQuadrants (Positioning top players across leaders, emerging companies, innovators, strategic players) annually in high growth emerging segments. MarketsandMarkets™ is determined to benefit more than 10,000 companies this year for their revenue planning and help them take their innovations/disruptions early to the market by providing them research ahead of the curve. MarketsandMarkets's flagship competitive intelligence and market research platform, "RT" connects over 200,000 markets and entire value chains for deeper understanding of the unmet insights along with market sizing and forecasts of niche markets. Connect with us on LinkedIn @ http://www.linkedin.com/company/marketsandmarkets


News Article | May 4, 2017
Site: www.prnewswire.com

Browse 66 market data Tables and 67 Figures spread through 153 Pages and in-depth TOC on "Bone Growth Stimulator Market" Early buyers will receive 10% customization on this report. On the basis of product, the global Bone Growth Stimulators Market is segmented into bone growth stimulation devices, bone morphogenetic protein (BMPs), and platelet-rich plasma (PRP). The bone growth stimulation devices segment accounted for the largest share of the market in 2016. This large share is attributed to the growing aging population, rising preference for non-surgical treatment procedures, and growing prevalence of nonunion fractures. Additionally, the rising incidence of obesity, smoking, and diabetes which delay or inhibit bone healing after surgery or trauma are further driving the market growth. On the basis of application, the global Bone Growth Stimulators Market is segmented into spinal fusion surgeries, delayed union and nonunion bone fractures, oral and maxillofacial surgeries, and other applications. The spinal fusion surgeries segment accounted for the largest share of the market in 2016. The large share of this segment is attributed to the growing geriatric population, rising number of spine procedures (and rate of spinal fusion failure), established safety and efficacy of stimulators in fusion surgery, and increasing use of bone growth stimulation products. On the basis of end user, the global Bone Growth Stimulators Market is segmented into hospitals & clinics, home care, and academic & research institutes and CROs. The hospitals & clinics segment is expected to grow at the highest CAGR during the forecast period. The advantage of bone growth stimulation products over their counterparts is the key factor driving their adoption in this end-user segment. On the basis of region, this Bone Growth Stimulators Market is classified into North America, Europe, Asia-Pacific, and the Rest of the World. In 2016, the global Bone Growth Stimulators Market was dominated by North America mainly due to the growing elderly population, increasing incidence of arthritis and sports injuries, adoption of novel treatment options, and rising demand for minimally invasive spinal surgeries. However, the Asia-Pacific market is expected to grow at the highest CAGR during 2017-2022. This is primarily due to the presence of a large patient population for target diseases (coupled with rapidly growing geriatric population, especially in Japan and China), rising awareness among healthcare professionals related to novel and upcoming treatment options, and ongoing government initiatives to modernize & expand healthcare infrastructure. Orthofix International N.V. (U.S.), DJO Finance LLC (U.S.), Zimmer Biomet Holdings, Inc. (U.S.), Bioventus LLC (U.S.), Medtronic plc (Ireland), Stryker Corporation (U.S.), DePuy Synthes (U.S.), Arthrex, Inc. (U.S.), and Harvest Technologies Corporation (U.S.) are some of the key players in the Bone Growth Stimulators Market. Spinal Implants and Surgical Devices Market by Technology (Fusion, Fixation, VCF, Decompression, Motion Preservation), Product (Thoracic, Lumbar, Cervical, Interbody, Kyphoplasty, Artificial Discs, MIS, Biologics, Stimulators) - Global Forecast to 2022. MarketsandMarkets™ provides quantified B2B research on 30,000 high growth niche opportunities/threats which will impact 70% to 80% of worldwide companies' revenues. Currently servicing 5000 customers worldwide including 80% of global Fortune 1000 companies as clients. Almost 75,000 top officers across eight industries worldwide approach MarketsandMarkets™ for their painpoints around revenues decisions. Our 850 fulltime analyst and SMEs at MarketsandMarkets™ are tracking global high growth markets following the "Growth Engagement Model - GEM". The GEM aims at proactive collaboration with the clients to identify new opportunities, identify most important customers, write "Attack, avoid and defend" strategies, identify sources of incremental revenues for both the company and its competitors. MarketsandMarkets™ now coming up with 1,500 MicroQuadrants (Positioning top players across leaders, emerging companies, innovators, strategic players) annually in high growth emerging segments. MarketsandMarkets™ is determined to benefit more than 10,000 companies this year for their revenue planning and help them take their innovations/disruptions early to the market by providing them research ahead of the curve. MarketsandMarkets's flagship competitive intelligence and market research platform, "RT" connects over 200,000 markets and entire value chains for deeper understanding of the unmet insights along with market sizing and forecasts of niche markets. Connect with us on LinkedIn @ http://www.linkedin.com/company/marketsandmarkets


News Article | April 26, 2017
Site: marketersmedia.com

— Global Lower Extremities Market 2017-2021 is growing popularity of MI procedures. Traditional open surgeries can cause post-operation complications such as pain, partially collapsed lungs, blood clots, fatigue, muscle atrophy, and infections. The anesthesia administered before surgeries can cause nausea, sore throat, confusion, and sleepiness. To reduce such complications, medical facilities have started implementing MI techniques in their surgical procedures. Complete report on lower extremities market spread across 70 pages, analyzing 3 major companies and provides 58 data exhibits is now available at http://www.reportsnreports.com/reports/966148-global-lower-extremities-market-2017-2021.html . The report, Global Lower Extremities Market 2017-2021, has been prepared based on an in-depth market analysis with inputs from industry experts. This report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market. According to the lower extremities market report, one driver in market is hip replacement procedures in UK. The joint replacement surgeries such as hip and knee replacement and revision procedures are increasing the need for lower extremity products in the market. For the replacement procedure, artificial implants are used, which replaces the joints in hip and knees. In 2002, the National Joint Registry was set up by the Department of Health and Welsh Government, UK. The registry collects the orthopedic reconstruction data from the NHS and procedures performed in the NHS hospitals. According to the National Joint Registry, the number of revision hip replacement procedures performed in 2014 and 2015 were 8,176 and 7,214, respectively. For hip replacement revision cases, a dip in the number of cases was observed in 2015 owing to the increased use of advanced lower extremity products. The analysts forecast global lower extremities market to grow at a CAGR of 7.66% during the period 2017-2021. Key players in the global lower extremities market: DePuy Synthes, Stryker, and Zimmer Biomet. Other Prominent Vendors in the market are: Active Implants, Acumed, Arthrex, Avitus Orthopaedics, Biotech Limb and Brace, Bioventus, Bone Therapeutics, Bone Biologics, Ceramisys, ConforMIS, CONMED, CollPlant, DJO Global, Evolutis, Exactech, FH Orthopedics, Graftys, ICONACY Orthopedic Implants, Integra LifeSciences, implantcast, Isto Biologics , Lima Corporate, Medtronic, Merete Group, Össur, OsteoMed, Orthofix, Orthogem, Promedics Orthopaedic, Regenexx,, RTI Surgical, Sigma Graft, Silver Bullet Therapeutics, Skye Biologics, Smith & Nephew, Stanmore Implants Worldwide, Surgical Appliance Industries, Wright Medical Group, and Xtant Medical. Further, the report states that one challenges in market is high procedure cost. Hospitals and surgical centers are under constant pressure to deliver quality care at low cost. However, this has become difficult due to the implementation of advanced procedures that involve the use of sophisticated devices. Hospitals and ASCs need to consider various procurement processes and budget allocation considerations before purchasing such devices. To increase their budget, hospitals sometimes implement the procedure cost, which can be high for the individuals. It increases cost burden on them, which hinders the market adoption. High procedure cost can impact the market growth negatively. About Us: ReportsnReports.com is single source for all market research needs. Our database includes 500,000+ market research reports from over 100+ leading global publishers & in-depth market research studies of over 5000 micro markets. With comprehensive information about the publishers and the industries for which they publish market research reports, we help in purchase decision by mapping your information needs with our huge collection of reports. For more information, please visit http://www.reportsnreports.com/reports/966148-global-lower-extremities-market-2017-2021.html


Patent
Mathys AG Bettlach and Bioventus | Date: 2017-04-26

The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH), the granules comprising interconnected pores with a minimum mean diameter of 3 microns, to a first incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43- ions; (b) subjecting the granules to a second incubation in an alkaline aqueous solution having a pH-value of more than 10 and optionally PO43- ions; (c) filtering and drying the obtained porous granules of calcium deficient hydroxyapatite; and wherein (d) the sum of the amounts of PO43- ions present in the first and second incubation is at least as large as the amount of SO42- ions of the granules used for step (a). The porous calcium deficient hydroxyapatite granules obtained by the invention may be purposefully used as carriers for biologically active substances in particular for proteins.


Patent
Mathys AG Bettlach and Bioventus | Date: 2017-04-26

The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43- ions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of PO43- ions present in the incubation of step a) is at least as large as the amount of SO42- ions of the granules used for step (a). The porous calcium deficient hydroxyapatite granules obtained by the invention may be purposefully used as carriers for biologically active substances in particular for proteins.


Patent
Bioventus | Date: 2016-02-04

Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.

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