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Talbott S.M.,SupplementWatch | Talbott J.A.,SupplementWatch | George A.,Biotropics Malaysia Berhad | Pugh M.,MonaVie
Journal of the International Society of Sports Nutrition | Year: 2013

Background: Eurycoma longifolia is a medicinal plant commonly called tongkat ali (TA) and " Malaysian ginseng." TA roots are a traditional " anti-aging" remedy and modern supplements are intended to improve libido, energy, sports performance and weight loss. Previous studies have shown properly-standardized TA to stimulate release of free testosterone, improve sex drive, reduce fatigue, and improve well-being.Methods: We assessed stress hormones and mood state in 63 subjects (32 men and 31 women) screened for moderate stress and supplemented with a standardized hot-water extract of TA root (TA) or Placebo (PL) for 4 weeks. Analysis of variance (ANOVA) with significance set at p < 0.05 was used to determine differences between groups.Results: Significant improvements were found in the TA group for Tension (-11%), Anger (-12%), and Confusion (-15%). Stress hormone profile (salivary cortisol and testosterone) was significantly improved by TA supplementation, with reduced cortisol exposure (-16%) and increased testosterone status (+37%).Conclusion: These results indicate that daily supplementation with tongkat ali root extract improves stress hormone profile and certain mood state parameters, suggesting that this " ancient" remedy may be an effective approach to shielding the body from the detrimental effects of " modern" chronic stress, which may include general day-to-day stress, as well as the stress of dieting, sleep deprivation, and exercise training. © 2013 Talbott et al.; licensee BioMed Central Ltd. Source


George A.,Biotropics Malaysia Berhad | Henkel R.,University of the Western Cape | Henkel R.,Center for Male Reproductive Health and Biotechnology
Andrologia | Year: 2014

The testosterone deficiency syndrome (TDS) is characterised by numerous symptoms, including low libido, increased fat mass, fatigue, erectile dysfunction or osteoporosis, and up to 80% of men will experience some kind of ageing males' symptoms. This is caused by the age-depending decline in serum testosterone levels with concentrations being about 40-50% lower in men older than 60 years compared with young men. This significant decline in testosterone levels is further closely linked with medical conditions such as obesity, metabolic syndrome, diabetes or hypertension. The conventional way of treating TDS is the testosterone replacement therapy (TRT), for which preparations are on the market. Apart from the beneficial effects of TRT, significant adverse side effects have been described, and prostate cancer (PCa) as absolute contraindication is debated. Eurycoma longifolia (Tongkat Ali; TA) is natural alternative to TRT and has been shown to restore serum testosterone levels, thus significantly improving sexual health. This includes significant positive effects on bone health and physical condition of patients. In addition, a significant antihyperglycaemic effect and cytotoxicity against PCas cells has been shown. Thus far, at therapeutic concentrations, no significant side effects of the treatment were obvious. Therefore, TA might be a safe alternative to TRT. © 2014 Blackwell Verlag GmbH. Source


Patent
Biotropics Malaysia Berhad | Date: 2013-02-26

The present invention relates to a composition containing an extract from the


Patent
Biotropics Malaysia Berhad | Date: 2010-12-20

The present invention relates to the use of compounds of isopimarane diterpene type, e.g. obtainable as or from extracts from The isopimarane diterpene type compounds can be of the formula wherein the symbols are as defined in the description and claims.


Patent
Biotropics Malaysia Berhad | Date: 2012-03-09

The present invention primarily relates to the use of certain extract formulations of

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