Biotherapy Center

Laboratory of, China

Biotherapy Center

Laboratory of, China

Time filter

Source Type

Long X.,Tianjin Medical University | Ye Y.,Biotherapy Center | Zhang L.,Tianjin Medical University | Liu P.,Biotherapy Center | And 5 more authors.
International Journal of Oncology | Year: 2016

The epithelial-mesenchymal transition (EMT) is a process through which epithelial cells trans-differentiate and acquire an aggressive mesenchymal phenotype. In tumor cells, EMT is a vital step of tumor progression and metastasis. Amid the increasing interest in tumor EMT, only a few studies focused on the soluble mediators secreted by tumor cells passing through this phenotypic switch. In this review, we focus on the essential role of interleukin-8 (IL-8) signaling for the acquisition and maintenance of tumor EMT via direct and indirect mechanisms. Besides the autocrine loop between IL-8 and tumor cells that have gone through EMT, IL-8 could potentiate adjacent epithelial tumor cells into a mesenchymal phenotype via a paracrine mode. Moreover, understanding the role of IL-8 in EMT will provide insight into the pathogenesis of tumor progression and may facilitate the development of an effective strategy for the prevention and treatment of metastatic cancer.

Loading Biotherapy Center collaborators
Loading Biotherapy Center collaborators