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Loizzo M.R.,University of Calabria | Ben Jemia M.,Biotechnologic Center Borj Cedria Technopark | Senatore F.,University of Naples Federico II | Bruno M.,University of Palermo | And 2 more authors.
Food and Chemical Toxicology | Year: 2013

The chemical composition of Cistus creticus, Cistus salvifolius, Cistus libanotis, Cistus monspeliensis and Cistus villosus essential oils has been examined by GC and GC-MS analysis. Height-nine constituents were identified in C. salvifolius oil, sixty in C. creticus, fifty-six in C. libanotis, fifty-four in C. villosus, forty-five in C. monspeliensis. Although the five species belong to the same genus, the composition showed interesting differences. Essential oils were screened also for their potential antioxidant effects (by DPPH, ABTS, FRAP and β-carotene bleaching test) and their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity, useful for prevention and treatment of Alzheimer's disease. C. monspeliensis exhibited the most promising activity in β-carotene bleaching test (IC50 of 54.7μg/mL). In FRAP test C. libanotis showed a value of 19.2μM Fe(II)/g. C. salvifolius showed the highest activity against AChE (IC50 of 58.1μg/mL) while C. libanotis, C. creticus, C. salvifolius demonstrated a good inhibitory activity against BChE with IC50 values of 23.7, 29.1 and 34.2μg/mL, respectively. Overall our results could promote the use of the essential oil of different Cistus species as food additives and for formulation of herbal infusion or nutraceutical products. © 2013 Elsevier Ltd.


Jemia M.B.,Biotechnologic Center Borj Cedria Technopark | Senatore F.,University of Naples Federico II | Bruno M.,University of Palermo | Bancheva S.,Bulgarian Academy of Science
Records of Natural Products | Year: 2015

Volatile components from florets, leaves and stems and branches of Centaurea aeolica Guss. harvested in Lipari, Sicily, Italy, were analysed by gas phase chomatography (GC) and gas chomatography mass spectrometry (GC-MS). The main constituents were β-eudesmol, caryophyllene oxide, (E)-12-norcaryophyll-5-en-2-one and hexahydrofarnesylacetone in flowers, hexahydrofarnesylacetone, 2-methyloctadecane and tricosane in the leaves and hexadecanoic acid, caryophyllene oxide and β-eudesmol in the stems and branches. The analysis of the essential oil of the aerial parts of Centaurea diluta Aiton gave mainly fatty acids and derivatives, the main ones being hexadecanoic acid and (Z,Z)-9,12-octadecadienoic acid methyl ester. © 2015 ACG Publications. All rights reserved.


Ben Jemia M.,Biotechnologic Center Borj Cedria Technopark | Kchouk M.E.,Biotechnologic Center Borj Cedria Technopark | Senatore F.,University of Naples Federico II | Autore G.,University of Salerno | And 3 more authors.
Chemistry Central Journal | Year: 2013

Background: As a part of our investigation on Tunisian medicinal plants, we have carried out a phytochemical investigation of the hexane extracts from leaves of Cistus libanotis, C. villosus and C. monspeliensis, evualuating also their possible antiproliferative activity in vitro.Results: The major compounds of hexane extracts were identified and quantified by GC-MS. The composition of the three species, although belonging to the same genus, is completely different. The antiproliferative activity was evaluated against murine monocyte/macrophages (J774.A1), human melanoma cells (A-375), and human breast cancer cells (MCF-7), showing major activity against the human melanoma cell line A-375.Conclusions: The chemical composition of the hexane extracts from the three Cistus species can be useful in the chemosystematics of this complex genus. The preliminary antiproliferative activity against human melanoma cell line A-375 deserve further investigations in order to determine the compounds, or their combinations, which are the main responsible for the antiproliferative activity and its possible mechanism(s) of action. © 2013 Ben Jemia et al; licensee Chemistry Central Ltd.


Jemia M.B.,Biotechnologic Center Borj Cedria Technopark | Wannes W.A.,Biotechnologic Center Borj Cedria Technopark | Ouchikh O.,Biotechnologic Center Borj Cedria Technopark | Bruno M.,University of Palermo | Kchouk M.E.,Biotechnologic Center Borj Cedria Technopark
Natural Product Research | Year: 2013

The present investigation focuses on the methanolic extract obtained from Geranium robertianum L. (Geraniaceae) (Herb Robert), a herbal plant used in traditional medicine for the treatment of human and animal diseases. The antioxidant capacities of the extract were evaluated using 1,1-diphenyl-2- picrylhydrazyl radical, β-carotene/linoleic acid and reducing power and metal chelating activity assays. The amount of total phenolic content, flavonoids and condensed tannins was very high, and the correlation between the antioxidant activity potential and total phenolic level of the extract was pointed out. © 2013 Taylor & Francis.


Wannes W.A.,Biotechnologic Center Borj Cedria Technopark | Marzouk B.,Biotechnologic Center Borj Cedria Technopark
Journal of Food and Drug Analysis | Year: 2016

This study aimed to characterize the chemical composition and antioxidant activity of the oil and the methanolic extract of Myrtus communis var. baetica seed. The oil yield of myrtle seed was 8.90%, with the amount of neutral lipid, especially triacylglycerol, being the highest, followed by phospholipids and glycolipids. Total lipids and all lipid classes were rich in linoleic acid. The content of total phenols, flavonoids, tannins, and proanthocyanidins of the methanolic extract and the oil from myrtle seed was determined using spectrophotometric methods. Antioxidant activities of the oil and the methanolic extract from myrtle seed were evaluated using 1,1-diphenyl-2-picrylhydrazyl radical scavenging, β-carotene-linoleic acid bleaching, and reducing power and metal chelating activity assays. In all tests, the methanolic extract of myrtle seed showed better antioxidant activity than oil. This investigation could suggest the use of myrtle seed in food, industrial, and biomedical applications for its potential metabolites and antioxidant abilities. © 2015.

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