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Chokpaiboon S.,Chulalongkorn University | Sommit D.,Mahanakorn University of Technology | Teerawatananond T.,Chulalongkorn University | Muangsin N.,Chulalongkorn University | And 2 more authors.
Journal of Natural Products | Year: 2010

A new nor-chamigrane endoperoxide, merulin A (1), and two new chamigrane endoperoxides, merulins B and C (2, 3), were isolated from the culture broth extract of an endophytic fungus of Xylocarpus granatum. Their structures were elucidated on the basis of spectroscopic, mainly NMR and MS, data. X-ray crystallographic analysis confirmed the structure of 1. Compounds 1 and 3 displayed significant cytotoxicity against human breast (BT474) and colon (SW620) cancer cell lines. © 2010 The American Chemical Society and American Society of Pharmacognosy. Source


Dejnirattisai W.,Imperial College London | Jumnainsong A.,Imperial College London | Onsirisakul N.,Imperial College London | Onsirisakul N.,Mahidol University | And 13 more authors.
Science | Year: 2010

Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common. One hypothesis for the increased severity seen in secondary infections is antibodydependent enhancement (ADE) leading to increased replication in Fc receptor-bearing cells. In this study, we have generated a panel of human monoclonal antibodies to dengue virus. Antibodies to the structural precursor-membrane protein (prM) form a major component of the response. These antibodies are highly cross-reactive among the dengue virus serotypes and, even at high concentrations, do not neutralize infection but potently promote ADE. We propose that the partial cleavage of prM from the viral surface reduces the density of antigen available for viral neutralization, leaving dengue viruses susceptible to ADE by antibody to prM, a finding that has implications for future vaccine design. Source


Mongkolsamrit S.,BIOTEC | Nguyen T.T.,Vinh University | Tran N.L.,Vinh University | Luangsa-Ard J.J.,BIOTEC
Mycotaxon | Year: 2011

Moelleriella pumatensis, a fungal pathogen infecting scale insect nymphs (Hemiptera), is described and illustrated as a new species from Pu Mat National Park in Vietnam. This species is unique in producing a golden yellow spore mass surrounding the stroma. In surveys throughout the year in Vietnam, only the anamorphic state has been found in the natural forest. Morphological characters and phylogenetic analysis of translation elongation factor 1-α (tef1) reveals this species as an anamorph of Moelleriella. © 2011 Publishing Technology. Source


Mongkolsamrit S.,BIOTEC | Khonsanit A.,BIOTEC | Noisripoom W.,BIOTEC | Baldorj P.,Mongolian Academy of science | Luangsa-Ard J.J.,BIOTEC
Mycotaxon | Year: 2014

Aschersonia narathiwatensis was isolated from whitefly nymphs (Hemiptera) collected at Hala-Bala Wildlife Sanctuary in Narathiwat Province, Thailand. This species has circular flattened-discoid brown to dark brown stroma and non-fragmenting ascospores. A comparison of macro-and microscopic characters among similar species is given. Phylogenetic analyses of nuclear ribosomal large subunit (LSU) and translation elongation factor 1-α (TEF-1α) support recognizing this fungus as a new species. © 2014. Mycotaxon, Ltd. Source

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