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Guergova-Kuras M.,Biosystems International
Molecular & cellular proteomics : MCP | Year: 2011

A challenge in the treatment of lung cancer is the lack of early diagnostics. Here, we describe the application of monoclonal antibody proteomics for discovery of a panel of biomarkers for early detection (stage I) of non-small cell lung cancer (NSCLC). We produced large monoclonal antibody libraries directed against the natural form of protein antigens present in the plasma of NSCLC patients. Plasma biomarkers associated with the presence of lung cancer were detected via high throughput ELISA. Differential profiling of plasma proteomes of four clinical cohorts, totaling 301 patients with lung cancer and 235 healthy controls, identified 13 lung cancer-associated (p < 0.05) monoclonal antibodies. The monoclonal antibodies recognize five different cognate proteins identified using immunoprecipitation followed by mass spectrometry. Four of the five antigens were present in non-small cell lung cancer cells in situ. The approach is capable of generating independent antibodies against different epitopes of the same proteins, allowing fast translation to multiplexed sandwich assays. Based on these results, we have verified in two independent clinical collections a panel of five biomarkers for classifying patient disease status with a diagnostics performance of 77% sensitivity and 87% specificity. Combining CYFRA, an established cancer marker, with the panel resulted in a performance of 83% sensitivity at 95% specificity for stage I NSCLC. Source


Shujun L.,Beijing Aeronautical Science and Technology Research Institute | Shujun L.,Biosystems International
AMA, Agricultural Mechanization in Asia, Africa and Latin America | Year: 2016

Agricultural machinery, as the material basis for developing modern agriculture, is an indispensable means for improving agricultural production efficiency, transforming the agricultural development pattern, enhancing the comprehensive competitiveness of agriculture, and ensuring national food security and effective supply of agricultural products. In recent years, in the process of rapid socio-economic growth in rural China, with the effective implementation of agriculture and farmers-friendly policies, agricultural machinery has become a most dynamic industry in the whole machinery sector in the country with daily improved research capacities and industrial technologies, and greatly enlarged product varieties and industrial scale. Under the new circumstances in the country, with the urbanization being accelerated and the rural labor increasingly transferred, development of farm machines suitable for the national conditions in the process of agricultural mechanization shall be the fundamental approach to solve the problem of "Who farm and how to farm", in order to meet the requirements in building up the modern agriculture with a sound mode and in a vertical direction. In this review, the paper describes the achievements made in the agricultural machinery and agricultural mechanization, the implementation of the key Sci-Tech planning projects, the innovation of basic applied technologies and key common products, as well as the establishment of four-in-one industrial chain innovation system covering projects, bases, personnel and mechanism in China. It also summarizes the development of the major technologies and products from 7 perspectives such as precision farming and intelligent technologies, farm power and tractors, multifunctional working machines, harvesters, livestock machinery, agro-products and food processing equipment, and agro-forest biomass utilization equipment. In conclusion, the paper indicates the future trends and priorities in the sci-tech development of the agricultural machinery in China from the following four aspects: Strengthening basic research and advancing original innovative capabilities, developing key common technologies and equipment for sound supply of domestic agricultural machinery, upgrading the productivity and quality of high-end equipment, and accelerating going-global for agricultural engineering in the process of the internationalization. Source


News Article | July 19, 2010
Site: www.finsmes.com

Following the discovery of novel biomarkers for lung cancer, the company launched the development of a new blood test for the detection of lung cancer in May, 2009. This new funds, which were provided by the company’s existing investors, will be used to complete development of the test and bring it to the market in 2011. Commenting on the financing, Jean-Pierre Tirouflet, Chief Executive Officer of Biosystems International, said: “The renewed commitment by our shareholders demonstrates their confidence in our lung cancer program. These funds will help to accelerate our entry to market”.


Machida T.,Biosystems International
AMA, Agricultural Mechanization in Asia, Africa and Latin America | Year: 2011

The Japan Association of International Commission of Agriculture and Biosystems Engineering (JAICABE) was established in 1984 with approval of six academic societies and one association for contributing to the development of agricultural engineering technology. JAICABE held annual conventions and symposiums as academic projects, in addition to awarding ceremonies for fellow recognitions. It also participated in the activities of International Commission of Agricultural Engineering (CIGR) as the representative society of the country and sent its members as the officials to CIGR, along with committee members to the respective sections from Section 1 to Section 7. JAICABE worked jointly with the CIGR branch society at the Science Council of Japan to make proposals to the government for agricultural engineering and held international academic symposiums and workshops in cooperation with the council. Source


Hanssen I.M.,Scientia Terrae Research Institute | van Esse H.P.,Wageningen University | Ballester A.-R.,Biosystems International | Hogewoning S.W.,Wageningen University | And 5 more authors.
Plant Physiology | Year: 2011

Pepino mosaic virus (PepMV) is a highly infectious potexvirus and a major disease of greenhouse tomato (Solanum lycopersicum) crops worldwide. Damage and economic losses caused by PepMV vary greatly and can be attributed to differential symptomatology caused by different PepMV isolates. Here, we used a custom-designed Affymetrix tomato GeneChip array with probe sets to interrogate over 22,000 tomato transcripts to study transcriptional changes in response to inoculation of tomato seedlings with a mild and an aggressive PepMV isolate that share 99.4% nucleotide sequence identity. The two isolates induced a different transcriptomic response, despite accumulating to similar viral titers. PepMV inoculation resulted in repression of photosynthesis. In addition, defense responses were stronger upon inoculation with the aggressive isolate, in both cases mediated by salicylic acid signaling rather than by jasmonate signaling. Our results furthermore show that PepMV differentially regulates the RNA silencing pathway, suggesting a role for a PepMV-encoded silencing suppressor. Finally, perturbation of pigment biosynthesis, as shown by differential regulation of the flavonoid and lycopene biosynthesis pathways, was monitored. Metabolite analyses on mature fruits of PepMV-infected tomato plants, which showed typical fruit marbling, revealed a decrease in carotenoids, likely responsible for the marbled phenotype, and an increase in alkaloids and phenylpropanoids that are associated with pathogen defense in the yellow sectors of the fruit. © 2011 American Society of Plant Biologists. Source

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